Abstract
Previous [11C]flumazenil (FMZ) positron emission tomography (PET) investigations in patients with idiopathic generalized epilepsy (IGE) have demonstrated nonsignificant global cortical decreases in central benzodiazepine gamma-aminobutyric acid A (GABA[A]) receptor (cBZR) binding or focal decreases in the thalamus and increases in the cerebellar nuclei with no changes in cerebral cortex. We previously reported lower [11C]FMZ binding in cerebral cortex of IGE patients treated with valproate (VPA) than in cerebral cortex of controls. We now report high-resolution three-dimensional [11C]FMZ PET studies in a larger number of subjects using an improved method to detect differences in cBZR between IGE patients and controls and a more powerful longitudinal design to determine the functional effect of VPA.
| Original language | English |
|---|---|
| Pages (from-to) | 1089-97 |
| Number of pages | 9 |
| Journal | Epilepsia |
| Volume | 38 |
| Issue number | 10 |
| Publication status | Published - 1997 |
Keywords
- Adult
- Analysis of Variance
- Brain
- Carbon Radioisotopes
- Cerebellum
- Cerebral Cortex
- Epilepsy, Generalized
- Female
- Flumazenil
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Receptors, GABA-A
- Thalamus
- Tomography, Emission-Computed
- Valproic Acid