Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice

Jean Rodgers; Barbara BRADLEY; Peter G.E. Kennedy; Jeremy M Sternberg

doi:10.1371/journal.pntd.0004201

Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice

Jean Rodgers, Barbara BRADLEY, Peter G.E. Kennedy, Jeremy M Sternberg^* (Corresponding Author)

^*Corresponding author for this work

Aberdeen Centre For Environmental Sustainability

University of Glasgow

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Abstract

Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 systemic inflammatory response. Using the Trypanosoma brucei brucei GVR35 experimental infection model, we demonstrate that systemic delivery of the counter-inflammatory cytokine IL-10 lowers plasma IFN-γ and TNF-α concentrations, CNS parasitosis and ameliorates neuro-inflammatory pathology and clinical symptoms of disease. The results provide evidence that CNS invasion may be susceptible to immunological attenuation.

Original language	English
Article number	e0004201
Number of pages	9
Journal	PLoS Neglected Tropical Diseases
Volume	9
Issue number	10
Early online date	27 Oct 2015
DOIs	https://doi.org/10.1371/journal.pntd.0004201
Publication status	Published - 27 Oct 2015

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10.1371/journal.pntd.0004201Licence: CC BY

Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma bruceiInfected Mice
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Final published version, 548 KBLicence: CC BY

http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004201

Jeremy Sternberg
- Biological Sciences, Aberdeen Centre For Environmental Sustainability - Reader
Person: Academic

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Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice

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