Cerebral blood flow by arterial spin labeling in poststroke dementia

M. J. Firbank*, J. He, A. M. Blamire, B. Singh, P. Danson, R. N. Kalaria, J. T. O'Brien

*Corresponding author for this work

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective: To investigate the relationship between cerebral blood flow and dementia in older stroke survivors and subjects with Alzheimer disease (AD).

Methods: This cohort study used arterial spin labeling MRI at 3T to examine cerebral blood flow (CBF). We scanned 39 patients 6 years after stroke. They were older than 75 years at the time of stroke and free of dementia 3 months poststroke, with 8 subsequently developing dementia. We also scanned 17 subjects with AD and 29 healthy control subjects. We determined the perfusion in regions of interest (ROIs). Hippocampal volume was also measured using a previously validated automated procedure.

Results: The gray matter/white matter CBF ratio was reduced globally in the poststroke dementia (PSD) group (1.55 SD = 0.12) relative to control subjects (1.78 SD = 0.18; p = 0.03). The CBF ratio in a parietal ROI was reduced in the AD (1.34 SD = 0.31; p = 0.003), PSD (1.32 SD = 0.22; p = 0.041), and poststroke no-dementia (PSND) (1.44 SD = 0.34; p = 0.014) groups relative to that of control subjects (1.70 SD = 0.32). In subjects without stroke, the best predictor of dementia was hippocampus volume, whereas in the stroke group, it was the global CBF gray matter/white matter ratio. Hippocampus volume was not significantly different between the AD and PSD groups, and both had reduced hippocampi relative to those of control subjects and the PSND group.

Conclusions: We found evidence for both vascular and AD pathology in PSD, suggesting that both the direct impact of the stroke and subsequent development of AD-type changes play a role in the etiology of PSD. Neurology (R) 2011;76:1478-1484

Original languageEnglish
Pages (from-to)1478-1484
Number of pages7
JournalNeurology
Volume76
Issue number17
DOIs
Publication statusPublished - 26 Apr 2011

Keywords

  • ischemic vascular dementia
  • subtypes
  • spect
  • stroke survivors
  • diagnosis
  • PET
  • cognitive impairment
  • Alzheimers-disease

Cite this

Firbank, M. J., He, J., Blamire, A. M., Singh, B., Danson, P., Kalaria, R. N., & O'Brien, J. T. (2011). Cerebral blood flow by arterial spin labeling in poststroke dementia. Neurology, 76(17), 1478-1484. https://doi.org/10.1212/WNL.0b013e318217e76a

Cerebral blood flow by arterial spin labeling in poststroke dementia. / Firbank, M. J.; He, J.; Blamire, A. M.; Singh, B.; Danson, P.; Kalaria, R. N.; O'Brien, J. T.

In: Neurology, Vol. 76, No. 17, 26.04.2011, p. 1478-1484.

Research output: Contribution to journalArticle

Firbank, MJ, He, J, Blamire, AM, Singh, B, Danson, P, Kalaria, RN & O'Brien, JT 2011, 'Cerebral blood flow by arterial spin labeling in poststroke dementia', Neurology, vol. 76, no. 17, pp. 1478-1484. https://doi.org/10.1212/WNL.0b013e318217e76a
Firbank MJ, He J, Blamire AM, Singh B, Danson P, Kalaria RN et al. Cerebral blood flow by arterial spin labeling in poststroke dementia. Neurology. 2011 Apr 26;76(17):1478-1484. https://doi.org/10.1212/WNL.0b013e318217e76a
Firbank, M. J. ; He, J. ; Blamire, A. M. ; Singh, B. ; Danson, P. ; Kalaria, R. N. ; O'Brien, J. T. / Cerebral blood flow by arterial spin labeling in poststroke dementia. In: Neurology. 2011 ; Vol. 76, No. 17. pp. 1478-1484.
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AU - He, J.

AU - Blamire, A. M.

AU - Singh, B.

AU - Danson, P.

AU - Kalaria, R. N.

AU - O'Brien, J. T.

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N2 - Objective: To investigate the relationship between cerebral blood flow and dementia in older stroke survivors and subjects with Alzheimer disease (AD).Methods: This cohort study used arterial spin labeling MRI at 3T to examine cerebral blood flow (CBF). We scanned 39 patients 6 years after stroke. They were older than 75 years at the time of stroke and free of dementia 3 months poststroke, with 8 subsequently developing dementia. We also scanned 17 subjects with AD and 29 healthy control subjects. We determined the perfusion in regions of interest (ROIs). Hippocampal volume was also measured using a previously validated automated procedure.Results: The gray matter/white matter CBF ratio was reduced globally in the poststroke dementia (PSD) group (1.55 SD = 0.12) relative to control subjects (1.78 SD = 0.18; p = 0.03). The CBF ratio in a parietal ROI was reduced in the AD (1.34 SD = 0.31; p = 0.003), PSD (1.32 SD = 0.22; p = 0.041), and poststroke no-dementia (PSND) (1.44 SD = 0.34; p = 0.014) groups relative to that of control subjects (1.70 SD = 0.32). In subjects without stroke, the best predictor of dementia was hippocampus volume, whereas in the stroke group, it was the global CBF gray matter/white matter ratio. Hippocampus volume was not significantly different between the AD and PSD groups, and both had reduced hippocampi relative to those of control subjects and the PSND group.Conclusions: We found evidence for both vascular and AD pathology in PSD, suggesting that both the direct impact of the stroke and subsequent development of AD-type changes play a role in the etiology of PSD. Neurology (R) 2011;76:1478-1484

AB - Objective: To investigate the relationship between cerebral blood flow and dementia in older stroke survivors and subjects with Alzheimer disease (AD).Methods: This cohort study used arterial spin labeling MRI at 3T to examine cerebral blood flow (CBF). We scanned 39 patients 6 years after stroke. They were older than 75 years at the time of stroke and free of dementia 3 months poststroke, with 8 subsequently developing dementia. We also scanned 17 subjects with AD and 29 healthy control subjects. We determined the perfusion in regions of interest (ROIs). Hippocampal volume was also measured using a previously validated automated procedure.Results: The gray matter/white matter CBF ratio was reduced globally in the poststroke dementia (PSD) group (1.55 SD = 0.12) relative to control subjects (1.78 SD = 0.18; p = 0.03). The CBF ratio in a parietal ROI was reduced in the AD (1.34 SD = 0.31; p = 0.003), PSD (1.32 SD = 0.22; p = 0.041), and poststroke no-dementia (PSND) (1.44 SD = 0.34; p = 0.014) groups relative to that of control subjects (1.70 SD = 0.32). In subjects without stroke, the best predictor of dementia was hippocampus volume, whereas in the stroke group, it was the global CBF gray matter/white matter ratio. Hippocampus volume was not significantly different between the AD and PSD groups, and both had reduced hippocampi relative to those of control subjects and the PSND group.Conclusions: We found evidence for both vascular and AD pathology in PSD, suggesting that both the direct impact of the stroke and subsequent development of AD-type changes play a role in the etiology of PSD. Neurology (R) 2011;76:1478-1484

KW - ischemic vascular dementia

KW - subtypes

KW - spect

KW - stroke survivors

KW - diagnosis

KW - PET

KW - cognitive impairment

KW - Alzheimers-disease

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DO - 10.1212/WNL.0b013e318217e76a

M3 - Article

VL - 76

SP - 1478

EP - 1484

JO - Neurology

JF - Neurology

SN - 0028-3878

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ER -