Abstract
Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that of recurrent ischaemic stroke when treated with antithrombotic drugs. We therefore aimed to establish whether a large burden of cerebral microbleeds or particular anatomical patterns of cerebral microbleeds can identify ischaemic stroke or transient ischaemic attack patients at higher absolute risk of intracranial haemorrhage than ischaemic stroke.
| Original language | English |
|---|---|
| Pages (from-to) | 653-665 |
| Number of pages | 13 |
| Journal | The Lancet neurology |
| Volume | 18 |
| Issue number | 7 |
| Early online date | 23 May 2019 |
| DOIs | |
| Publication status | Published - 1 Jul 2019 |
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- 10.1016/S1474-4422(19)30197-8Licence: CC BY
- Wilson_lancet_cerberal-microbleeds_VOR
https://creativecommons.org/licenses/by/4.0/
Final published version, 818 KBLicence: CC BY
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Stephen Makin
- School of Medicine, Medical Sciences & Nutrition, Applied Health Sciences - Senior Lecturer (Clinical)
Person: Clinical Academic
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Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack : a pooled analysis of individual patient data from cohort studies. / Wilson, Duncan; Ambler, Gareth; Lee, Keon-Joo; Lim, Jae-Sung; Shiozawa, Masayuki; Koga, Masatoshi; Li, Linxin; Lovelock, Caroline; Chabriat, Hugues; Hennerici, Michael; Wong, Yuen Kwun; Mak, Henry Ka Fung; Prats-Sánchez, Luis; Martínez-Domeño, Alejandro; Inamura, Shigeru; Yoshifuji, Kazuhisa; Arsava, Ethem Murat; Horstmann, Solveig; Purrucker, Jan; Lam, Bonnie Yin Ka; Wong, Adrian; Kim, Young Dae; Song, Tae-Jin; Schrooten, Maarten; Lemmens, Robin; Eppinger, Sebastian; Gattringer, Thomas; Uysal, Ender; Tanriverdi, Zeynep; Bornstein, Natan M.; Assayag, Einor Ben; Hallevi, Hen; Tanaka, Jun; Hara, Hideo; Coutts, Shelagh B.; Hert, Lisa; Polymeris, Alexandros; Seiffge, David J.; Lyrer, Philippe; Algra, Ale; Kappelle, Jaap; Al-Shahi Salman, Rustam; Jäger, Hans R.; Lip, Gregory Y. H.; Mattle, Heinrich P.; Panos, Leonidas D.; Mas, Jean-Louis; Legrand, Laurence; Karayiannis, Christopher; Phan, Thanh; Gunkel, Sarah; Christ, Nicolas; Abrigo, Jill; Leung, Thomas; Chu, Winnie; Chappell, Francesca; Makin, Stephen; Hayden, Derek; Williams, David J.; Kooi, M. Eline; van Dam-Nolen, Dianne H. K.; Barbato, Carmen; Browning, Simone; Wiegertjes, Kim; Tuladhar, Anil M.; Maaijwee, Noortje; Guevarra, Christine; Yatawara, Chathuri; Mendyk, Anne-Marie; Delmaire, Christine; Köhler, Sebastian; van Oostenbrugge, Robert; Zhou, Ying; Xu, Chao; Hilal, Saima; Gyanwali, Bibek; Chen, Christopher; Lou, Min; Staals, Julie; Bordet, Régis; Kandiah, Nagaendran; de Leeuw, Frank-Erik; Simister, Robert; van der Lugt, Aad; Kelly, Peter J.; Wardlaw, Joanna M.; Soo, Yannie; Fluri, Felix; Srikanth, Velandai; Calvet, David; Jung, Simon; Kwa, Vincent I. H.; Engelter, Stefan T.; Peters, Nils; Smith, Eric E.; Yakushiji, Yusuke; Orken, Dilek Necioglu; Fazekas, Franz; Thijs, Vincent; Heo, Ji Hoe; Mok, Vincent; Veltkamp, Roland; Ay, Hakan; Imaizumi, Toshio; Gomez-Anson, Beatriz; Lau, Kui Kai; Jouvent, Eric; Rothwell, Peter M.; Toyoda, Kazunori; Bae, Hee-Joon; Marti-Fabregas, Joan; Werring, David J.; Harkness, Kirsty; Shaw, Louise; Sword, Jane; Mohd Nor, Azlisham; Sharma, Pankaj; Kelly, Deborah; Harrington, Frances; Randall, Marc; Smith, Matthew; Mahawish, Karim; Elmarim, Abduelbaset; Esisi, Bernard; Cullen, Claire; Nallasivam, Arumug; Price, Christopher; Barry, Adrian; Roffe, Christine; Coyle, John; Hassan, Ahamad; Birns, Jonathan; Cohen, David; Sekaran, Lakshmanan; Parry-Jones, Adrian; Parry, Anthea; Hargroves, David; Proschel, Harald; Datta, Prabel; Darawil, Khaled; Manoj, Aravindakshan; Burn, Mathew; Patterson, Chris; Giallombardo, Elio; Smyth, Nigel; Mansoor, Syed; Anwar, Ijaz; Marsh, Rachel; Ispoglou, Sissi; Chadha, Dinesh; Prabhakaran, Mathuri; Meenakishundaram, Sanjeevikumar; O'Connell, Janice; Scott, Jon; Krishnamurthy, Vinodh; Aghoram, Prasanna; McCormick, Michael; Sprigg, Nikola; O'Mahony, Paul; Cooper, Martin; Choy, Lillian; Wilkinson, Peter; Leach, Simon; Caine, Sarah; Burger, Ilse; Gunathilagan, Gunaratam; Guyler, Paul; Emsley, Hedley; Davis, Michelle; Manawadu, Dulka; Pasco, Kath; Mamun, Maam; Luder, Robert; Sajid, Mahmud; Okwera, James; Warburton, Elizabeth; Saastamoinen, Kari; England, Timothy; Putterill, Janet; Flossman, Enrico; Power, Michael; Dani, Krishna; Mangion, David; Suman, Appu; Corrigan, John; Lawrence, Enas; Vahidassr, Djamil; Shakeshaft, Clare; Brown, Martin; Charidimou, Andreas; Cohen, Hannah; Banerjee, Gargi; Houlden, Henry; White, Mark; Yousry, Tarek; Flossmann, Enrico; Muir, Keith; El-Koussy, Marwan; Gratz, Pascal; Molad, Jeremy; Korczyn, Amos; Kliper, Efrat; Maeder, Philippe; Gass, Achim; Pachai, Chahin; Bracoub, Luc; Douste-Blazy, Marie-Yvonne; Fratacci, Marie Dominique; Vicaut, Eric; Sato, Shoichiro; Miwa, Kaori; Fujita, Kyohei; Ide, Toshihiro; Ma, Henry; Ly, John; Singhal, Shahoo; Chandra, Ronil; Slater, Lee-Anne; Soufan, Cathy; Moran, Christopher; Traenka, Christopher; Thilemann, Sebastian; Fladt, Joachim; Gensicke, Henrik; Bonati, Leo; Kim, Beom Joon; Han, Moon-Ku; Kang, Jihoon; Ko, Eunbin; Yang, Mi Hwa; Jang, Myung Suk; Murphy, Sean; Carty, Fiona; Akijian, Layan; Thornton, John; Schembri, Mark; Douven, Elles; Delgado, Mederos; Escudero, Raquel; Marín, Rebeca; Camps-Renom, Pol; Guisado-Alonso, Daniel; Nuñez, Fidel; Medrano-Martorell, Santiago; Merino, Elisa; Iida, Kotaro; Ikeda, Syuhei; Nishihara, Masashi; Irie, Hiroyuki; Demirelli, Derya Selcuk; Medanta, Jayesh Modi; Zerna, Charlotte; Hernández, Maria Valdés; Armitage, Paul; Heye, Anna; Muñoz-Maniega, Susana; Sakka, Eleni; Thrippleton, Michael; Dennis, Martin; Beigneux, Ysoline; Silva, Mauro; Venketasubramanian, Narayanaswamy; Ho, Shu Leung; Cheung, Raymond Tak Fai; Chan, Koon Ho; Teo, Kay Cheong; Hui, Edward; Kwan, Joseph Shiu Kwong; Chang, Richard; Tse, Man Yu; Hoi, Chu Peng; Chan, Chung Yan; Chan, Oi Ling; Cheung, Ryan Hoi Kit; Wong, Edmund Ka Ming; Leung, Kam Tat; Tsang, Suk Fung; Ip, Hing Lung; Ma, Sze Ho; Ma, Karen; Fong, Wing Chi; Li, Siu Hung; Li, Richard; Ng, Ping Wing; Wong, Kwok Kui; Liu, Wenyan; Wong, Lawrence; Ramos, Lino; De Schryver, Els; Jöbsis, Joost; van der Sande, Jaap; Brouwers, Paul; Roos, Yvo; Stam, Jan; Bakker, Stef; Verbiest, Henk; Schoonewille, Wouter; Linn, Cisca; Hertzberger, Leopold; van Gemert, Maarten; Berntsen, Paul; Hendrikse, Jeroen; Nederkoorn, Paul; Mess, Werner; Koudstaal, Peter; Leff, Alexander; Ward, Nicholas; Nachev, Parashkev; Perry, Richard; Ozkan, Hatice; Mitchell, John.
In: The Lancet neurology, Vol. 18, No. 7, 01.07.2019, p. 653-665.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack
T2 - a pooled analysis of individual patient data from cohort studies
AU - Wilson, Duncan
AU - Ambler, Gareth
AU - Lee, Keon-Joo
AU - Lim, Jae-Sung
AU - Shiozawa, Masayuki
AU - Koga, Masatoshi
AU - Li, Linxin
AU - Lovelock, Caroline
AU - Chabriat, Hugues
AU - Hennerici, Michael
AU - Wong, Yuen Kwun
AU - Mak, Henry Ka Fung
AU - Prats-Sánchez, Luis
AU - Martínez-Domeño, Alejandro
AU - Inamura, Shigeru
AU - Yoshifuji, Kazuhisa
AU - Arsava, Ethem Murat
AU - Horstmann, Solveig
AU - Purrucker, Jan
AU - Lam, Bonnie Yin Ka
AU - Wong, Adrian
AU - Kim, Young Dae
AU - Song, Tae-Jin
AU - Schrooten, Maarten
AU - Lemmens, Robin
AU - Eppinger, Sebastian
AU - Gattringer, Thomas
AU - Uysal, Ender
AU - Tanriverdi, Zeynep
AU - Bornstein, Natan M.
AU - Assayag, Einor Ben
AU - Hallevi, Hen
AU - Tanaka, Jun
AU - Hara, Hideo
AU - Coutts, Shelagh B.
AU - Hert, Lisa
AU - Polymeris, Alexandros
AU - Seiffge, David J.
AU - Lyrer, Philippe
AU - Algra, Ale
AU - Kappelle, Jaap
AU - Al-Shahi Salman, Rustam
AU - Jäger, Hans R.
AU - Lip, Gregory Y. H.
AU - Mattle, Heinrich P.
AU - Panos, Leonidas D.
AU - Mas, Jean-Louis
AU - Legrand, Laurence
AU - Karayiannis, Christopher
AU - Phan, Thanh
AU - Gunkel, Sarah
AU - Christ, Nicolas
AU - Abrigo, Jill
AU - Leung, Thomas
AU - Chu, Winnie
AU - Chappell, Francesca
AU - Makin, Stephen
AU - Hayden, Derek
AU - Williams, David J.
AU - Kooi, M. Eline
AU - van Dam-Nolen, Dianne H. K.
AU - Barbato, Carmen
AU - Browning, Simone
AU - Wiegertjes, Kim
AU - Tuladhar, Anil M.
AU - Maaijwee, Noortje
AU - Guevarra, Christine
AU - Yatawara, Chathuri
AU - Mendyk, Anne-Marie
AU - Delmaire, Christine
AU - Köhler, Sebastian
AU - van Oostenbrugge, Robert
AU - Zhou, Ying
AU - Xu, Chao
AU - Hilal, Saima
AU - Gyanwali, Bibek
AU - Chen, Christopher
AU - Lou, Min
AU - Staals, Julie
AU - Bordet, Régis
AU - Kandiah, Nagaendran
AU - de Leeuw, Frank-Erik
AU - Simister, Robert
AU - van der Lugt, Aad
AU - Kelly, Peter J.
AU - Wardlaw, Joanna M.
AU - Soo, Yannie
AU - Fluri, Felix
AU - Srikanth, Velandai
AU - Calvet, David
AU - Jung, Simon
AU - Kwa, Vincent I. H.
AU - Engelter, Stefan T.
AU - Peters, Nils
AU - Smith, Eric E.
AU - Yakushiji, Yusuke
AU - Orken, Dilek Necioglu
AU - Fazekas, Franz
AU - Thijs, Vincent
AU - Heo, Ji Hoe
AU - Mok, Vincent
AU - Veltkamp, Roland
AU - Ay, Hakan
AU - Imaizumi, Toshio
AU - Gomez-Anson, Beatriz
AU - Lau, Kui Kai
AU - Jouvent, Eric
AU - Rothwell, Peter M.
AU - Toyoda, Kazunori
AU - Bae, Hee-Joon
AU - Marti-Fabregas, Joan
AU - Werring, David J.
AU - Harkness, Kirsty
AU - Shaw, Louise
AU - Sword, Jane
AU - Mohd Nor, Azlisham
AU - Sharma, Pankaj
AU - Kelly, Deborah
AU - Harrington, Frances
AU - Randall, Marc
AU - Smith, Matthew
AU - Mahawish, Karim
AU - Elmarim, Abduelbaset
AU - Esisi, Bernard
AU - Cullen, Claire
AU - Nallasivam, Arumug
AU - Price, Christopher
AU - Barry, Adrian
AU - Roffe, Christine
AU - Coyle, John
AU - Hassan, Ahamad
AU - Birns, Jonathan
AU - Cohen, David
AU - Sekaran, Lakshmanan
AU - Parry-Jones, Adrian
AU - Parry, Anthea
AU - Hargroves, David
AU - Proschel, Harald
AU - Datta, Prabel
AU - Darawil, Khaled
AU - Manoj, Aravindakshan
AU - Burn, Mathew
AU - Patterson, Chris
AU - Giallombardo, Elio
AU - Smyth, Nigel
AU - Mansoor, Syed
AU - Anwar, Ijaz
AU - Marsh, Rachel
AU - Ispoglou, Sissi
AU - Chadha, Dinesh
AU - Prabhakaran, Mathuri
AU - Meenakishundaram, Sanjeevikumar
AU - O'Connell, Janice
AU - Scott, Jon
AU - Krishnamurthy, Vinodh
AU - Aghoram, Prasanna
AU - McCormick, Michael
AU - Sprigg, Nikola
AU - O'Mahony, Paul
AU - Cooper, Martin
AU - Choy, Lillian
AU - Wilkinson, Peter
AU - Leach, Simon
AU - Caine, Sarah
AU - Burger, Ilse
AU - Gunathilagan, Gunaratam
AU - Guyler, Paul
AU - Emsley, Hedley
AU - Davis, Michelle
AU - Manawadu, Dulka
AU - Pasco, Kath
AU - Mamun, Maam
AU - Luder, Robert
AU - Sajid, Mahmud
AU - Okwera, James
AU - Warburton, Elizabeth
AU - Saastamoinen, Kari
AU - England, Timothy
AU - Putterill, Janet
AU - Flossman, Enrico
AU - Power, Michael
AU - Dani, Krishna
AU - Mangion, David
AU - Suman, Appu
AU - Corrigan, John
AU - Lawrence, Enas
AU - Vahidassr, Djamil
AU - Shakeshaft, Clare
AU - Brown, Martin
AU - Charidimou, Andreas
AU - Cohen, Hannah
AU - Banerjee, Gargi
AU - Houlden, Henry
AU - White, Mark
AU - Yousry, Tarek
AU - Flossmann, Enrico
AU - Muir, Keith
AU - El-Koussy, Marwan
AU - Gratz, Pascal
AU - Molad, Jeremy
AU - Korczyn, Amos
AU - Kliper, Efrat
AU - Maeder, Philippe
AU - Gass, Achim
AU - Pachai, Chahin
AU - Bracoub, Luc
AU - Douste-Blazy, Marie-Yvonne
AU - Fratacci, Marie Dominique
AU - Vicaut, Eric
AU - Sato, Shoichiro
AU - Miwa, Kaori
AU - Fujita, Kyohei
AU - Ide, Toshihiro
AU - Ma, Henry
AU - Ly, John
AU - Singhal, Shahoo
AU - Chandra, Ronil
AU - Slater, Lee-Anne
AU - Soufan, Cathy
AU - Moran, Christopher
AU - Traenka, Christopher
AU - Thilemann, Sebastian
AU - Fladt, Joachim
AU - Gensicke, Henrik
AU - Bonati, Leo
AU - Kim, Beom Joon
AU - Han, Moon-Ku
AU - Kang, Jihoon
AU - Ko, Eunbin
AU - Yang, Mi Hwa
AU - Jang, Myung Suk
AU - Murphy, Sean
AU - Carty, Fiona
AU - Akijian, Layan
AU - Thornton, John
AU - Schembri, Mark
AU - Douven, Elles
AU - Delgado, Mederos
AU - Escudero, Raquel
AU - Marín, Rebeca
AU - Camps-Renom, Pol
AU - Guisado-Alonso, Daniel
AU - Nuñez, Fidel
AU - Medrano-Martorell, Santiago
AU - Merino, Elisa
AU - Iida, Kotaro
AU - Ikeda, Syuhei
AU - Nishihara, Masashi
AU - Irie, Hiroyuki
AU - Demirelli, Derya Selcuk
AU - Medanta, Jayesh Modi
AU - Zerna, Charlotte
AU - Hernández, Maria Valdés
AU - Armitage, Paul
AU - Heye, Anna
AU - Muñoz-Maniega, Susana
AU - Sakka, Eleni
AU - Thrippleton, Michael
AU - Dennis, Martin
AU - Beigneux, Ysoline
AU - Silva, Mauro
AU - Venketasubramanian, Narayanaswamy
AU - Ho, Shu Leung
AU - Cheung, Raymond Tak Fai
AU - Chan, Koon Ho
AU - Teo, Kay Cheong
AU - Hui, Edward
AU - Kwan, Joseph Shiu Kwong
AU - Chang, Richard
AU - Tse, Man Yu
AU - Hoi, Chu Peng
AU - Chan, Chung Yan
AU - Chan, Oi Ling
AU - Cheung, Ryan Hoi Kit
AU - Wong, Edmund Ka Ming
AU - Leung, Kam Tat
AU - Tsang, Suk Fung
AU - Ip, Hing Lung
AU - Ma, Sze Ho
AU - Ma, Karen
AU - Fong, Wing Chi
AU - Li, Siu Hung
AU - Li, Richard
AU - Ng, Ping Wing
AU - Wong, Kwok Kui
AU - Liu, Wenyan
AU - Wong, Lawrence
AU - Ramos, Lino
AU - De Schryver, Els
AU - Jöbsis, Joost
AU - van der Sande, Jaap
AU - Brouwers, Paul
AU - Roos, Yvo
AU - Stam, Jan
AU - Bakker, Stef
AU - Verbiest, Henk
AU - Schoonewille, Wouter
AU - Linn, Cisca
AU - Hertzberger, Leopold
AU - van Gemert, Maarten
AU - Berntsen, Paul
AU - Hendrikse, Jeroen
AU - Nederkoorn, Paul
AU - Mess, Werner
AU - Koudstaal, Peter
AU - Leff, Alexander
AU - Ward, Nicholas
AU - Nachev, Parashkev
AU - Perry, Richard
AU - Ozkan, Hatice
AU - Mitchell, John
N1 - Funding: British Heart Foundation and UK Stroke Association.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - BackgroundCerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that of recurrent ischaemic stroke when treated with antithrombotic drugs. We therefore aimed to establish whether a large burden of cerebral microbleeds or particular anatomical patterns of cerebral microbleeds can identify ischaemic stroke or transient ischaemic attack patients at higher absolute risk of intracranial haemorrhage than ischaemic stroke.
AB - BackgroundCerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that of recurrent ischaemic stroke when treated with antithrombotic drugs. We therefore aimed to establish whether a large burden of cerebral microbleeds or particular anatomical patterns of cerebral microbleeds can identify ischaemic stroke or transient ischaemic attack patients at higher absolute risk of intracranial haemorrhage than ischaemic stroke.
UR - http://www.scopus.com/inward/record.url?scp=85067010802&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(19)30197-8
DO - 10.1016/S1474-4422(19)30197-8
M3 - Article
VL - 18
SP - 653
EP - 665
JO - The Lancet neurology
JF - The Lancet neurology
SN - 1474-4422
IS - 7
ER -