Changes in muscle morphology in dialysis patients after 6 months of aerobic exercise training

G. K. Sakkas, A. J. Sargeant, T. H. Mercer, Derek Ball, P. Koufaki, C. Karatzaferi, P. F. Naish

Research output: Contribution to journalArticle

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Abstract

Background. In the present study we investigated the effect of a 6-month aerobic exercise programme on the morphology of the gastrocnemius muscle of end-stage renal disease (ESRD) patients.

Methods. Twenty-four ESRD patients volunteered to participate in the training programme and underwent muscle biopsy before training. Eighteen patients completed the training programme of whom nine agreed to a post-training biopsy (one woman and eight men, mean age 56 15 years). Data are presented for the nine subjects who were biopsied before (PRE) and after training (POST) and separately for the 15 subjects for whom we only have a biopsy before training (cross-sectional group).

Results. There were no significant differences (P > 0.05) in fibre type distribution or myosin heavy chain (MyHC) expression between the cross-sectional and PRE/POST groups. The mean cross-section fibre area after training (POST) increased by 46% compared with the PRE training status (P < 0.01). The proportion of atrophic fibres decreased significantly after training in type I, IIa and IIx fibre populations (from 51 to 15%, 58 to 21% and 62 to 32%, respectively). Significant differences were also found in capillary contact per fibre (CC/F), with the muscle having 24% (P < 0.05) more CC/F compared with the PRE training status. No significant differences in cytochrome c oxidase concentration were found between the groups.

Conclusions. In conclusion, exercise appeared to be beneficial in renal rehabilitation by correcting the fibre atrophy, increasing the cross-section fibre area and improving the capillarization in the skeletal muscle of renal failure patients.

Original languageEnglish
Pages (from-to)1854-1861
Number of pages7
JournalNephrology Dialysis Transplantation
Volume18
DOIs
Publication statusPublished - 2003

Keywords

  • CAPD
  • capillary density
  • cytochrome c oxidase
  • exercise training
  • fibre types
  • gastrocnemius
  • haemodialysis
  • SKELETAL-MUSCLE
  • HEMODIALYSIS-PATIENTS
  • FIBER TYPES
  • ATROPHY
  • MEN

Cite this

Sakkas, G. K., Sargeant, A. J., Mercer, T. H., Ball, D., Koufaki, P., Karatzaferi, C., & Naish, P. F. (2003). Changes in muscle morphology in dialysis patients after 6 months of aerobic exercise training. Nephrology Dialysis Transplantation, 18, 1854-1861. https://doi.org/10.1093/ndt/gfg237

Changes in muscle morphology in dialysis patients after 6 months of aerobic exercise training. / Sakkas, G. K.; Sargeant, A. J.; Mercer, T. H.; Ball, Derek; Koufaki, P.; Karatzaferi, C.; Naish, P. F.

In: Nephrology Dialysis Transplantation, Vol. 18, 2003, p. 1854-1861.

Research output: Contribution to journalArticle

Sakkas, G. K. ; Sargeant, A. J. ; Mercer, T. H. ; Ball, Derek ; Koufaki, P. ; Karatzaferi, C. ; Naish, P. F. / Changes in muscle morphology in dialysis patients after 6 months of aerobic exercise training. In: Nephrology Dialysis Transplantation. 2003 ; Vol. 18. pp. 1854-1861.
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abstract = "Background. In the present study we investigated the effect of a 6-month aerobic exercise programme on the morphology of the gastrocnemius muscle of end-stage renal disease (ESRD) patients.Methods. Twenty-four ESRD patients volunteered to participate in the training programme and underwent muscle biopsy before training. Eighteen patients completed the training programme of whom nine agreed to a post-training biopsy (one woman and eight men, mean age 56 15 years). Data are presented for the nine subjects who were biopsied before (PRE) and after training (POST) and separately for the 15 subjects for whom we only have a biopsy before training (cross-sectional group).Results. There were no significant differences (P > 0.05) in fibre type distribution or myosin heavy chain (MyHC) expression between the cross-sectional and PRE/POST groups. The mean cross-section fibre area after training (POST) increased by 46{\%} compared with the PRE training status (P < 0.01). The proportion of atrophic fibres decreased significantly after training in type I, IIa and IIx fibre populations (from 51 to 15{\%}, 58 to 21{\%} and 62 to 32{\%}, respectively). Significant differences were also found in capillary contact per fibre (CC/F), with the muscle having 24{\%} (P < 0.05) more CC/F compared with the PRE training status. No significant differences in cytochrome c oxidase concentration were found between the groups.Conclusions. In conclusion, exercise appeared to be beneficial in renal rehabilitation by correcting the fibre atrophy, increasing the cross-section fibre area and improving the capillarization in the skeletal muscle of renal failure patients.",
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T1 - Changes in muscle morphology in dialysis patients after 6 months of aerobic exercise training

AU - Sakkas, G. K.

AU - Sargeant, A. J.

AU - Mercer, T. H.

AU - Ball, Derek

AU - Koufaki, P.

AU - Karatzaferi, C.

AU - Naish, P. F.

PY - 2003

Y1 - 2003

N2 - Background. In the present study we investigated the effect of a 6-month aerobic exercise programme on the morphology of the gastrocnemius muscle of end-stage renal disease (ESRD) patients.Methods. Twenty-four ESRD patients volunteered to participate in the training programme and underwent muscle biopsy before training. Eighteen patients completed the training programme of whom nine agreed to a post-training biopsy (one woman and eight men, mean age 56 15 years). Data are presented for the nine subjects who were biopsied before (PRE) and after training (POST) and separately for the 15 subjects for whom we only have a biopsy before training (cross-sectional group).Results. There were no significant differences (P > 0.05) in fibre type distribution or myosin heavy chain (MyHC) expression between the cross-sectional and PRE/POST groups. The mean cross-section fibre area after training (POST) increased by 46% compared with the PRE training status (P < 0.01). The proportion of atrophic fibres decreased significantly after training in type I, IIa and IIx fibre populations (from 51 to 15%, 58 to 21% and 62 to 32%, respectively). Significant differences were also found in capillary contact per fibre (CC/F), with the muscle having 24% (P < 0.05) more CC/F compared with the PRE training status. No significant differences in cytochrome c oxidase concentration were found between the groups.Conclusions. In conclusion, exercise appeared to be beneficial in renal rehabilitation by correcting the fibre atrophy, increasing the cross-section fibre area and improving the capillarization in the skeletal muscle of renal failure patients.

AB - Background. In the present study we investigated the effect of a 6-month aerobic exercise programme on the morphology of the gastrocnemius muscle of end-stage renal disease (ESRD) patients.Methods. Twenty-four ESRD patients volunteered to participate in the training programme and underwent muscle biopsy before training. Eighteen patients completed the training programme of whom nine agreed to a post-training biopsy (one woman and eight men, mean age 56 15 years). Data are presented for the nine subjects who were biopsied before (PRE) and after training (POST) and separately for the 15 subjects for whom we only have a biopsy before training (cross-sectional group).Results. There were no significant differences (P > 0.05) in fibre type distribution or myosin heavy chain (MyHC) expression between the cross-sectional and PRE/POST groups. The mean cross-section fibre area after training (POST) increased by 46% compared with the PRE training status (P < 0.01). The proportion of atrophic fibres decreased significantly after training in type I, IIa and IIx fibre populations (from 51 to 15%, 58 to 21% and 62 to 32%, respectively). Significant differences were also found in capillary contact per fibre (CC/F), with the muscle having 24% (P < 0.05) more CC/F compared with the PRE training status. No significant differences in cytochrome c oxidase concentration were found between the groups.Conclusions. In conclusion, exercise appeared to be beneficial in renal rehabilitation by correcting the fibre atrophy, increasing the cross-section fibre area and improving the capillarization in the skeletal muscle of renal failure patients.

KW - CAPD

KW - capillary density

KW - cytochrome c oxidase

KW - exercise training

KW - fibre types

KW - gastrocnemius

KW - haemodialysis

KW - SKELETAL-MUSCLE

KW - HEMODIALYSIS-PATIENTS

KW - FIBER TYPES

KW - ATROPHY

KW - MEN

U2 - 10.1093/ndt/gfg237

DO - 10.1093/ndt/gfg237

M3 - Article

VL - 18

SP - 1854

EP - 1861

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

SN - 0931-0509

ER -