Changes to exhaled nitric oxide in asthmatic children after drinking a caffeine-containing cola drink

I Abuzayan, U Paraskavi, S W Turner

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Introduction
Exhaled nitric oxide (FENO) may be a biomarker for airway eosinophilia and of use in the management of childhood asthma. Caffeine ingestion has been associated with changes in FENO concentration in adults. The present study tested the hypothesis that ingestion of a caffeine-containing cola drink will increase FENO in asthmatic children.
Methods
Exhaled NO was measured in children with asthma before, 30 and 60¿min after taking a cola drink containing 0.7¿mg/kg caffeine. Intrasubject changes in FENO and flow independent NO parameters were determined including bronchial wall NO flux (J'awNO).
Results
Eleven children with asthma were recruited, 10 were prescribed inhaled corticosteroids and 9 were skin prick positive. The median [interquartile range, IQR] FENO at baseline was 47 parts per billion [9,64] and this rose to 56¿ppb [11, 66] after 30¿min and returned to 46¿ppb [9, 62] after 60¿min, Friedman's test P¿=¿0.003. J'awNO rose from a median [IQR] 2,843¿nl/sec [356, 4,247] at baseline to 3,304¿nl/sec [479, 4,387] after 30¿min and returned to 2,937¿nl/sec [356, 4,153] after 60¿min, Freidman's test P¿=¿0.003. There was no significant change in other flow independent NO parameters.
Conclusions
Ingestion of a caffeine-containing cola drink was associated with a modest and transient rise in FENO which is mostly explained by increased NO production in the proximal airways. Ingestion of a caffeine-containing cola drink may result in clinically relevant acute changes in FENO for children with asthma. Pediatr Pulmonol. 2010;45:1228–1232. © 2010 Wiley-Liss, Inc.
Original languageEnglish
Pages (from-to)1228-1232
Number of pages5
JournalPediatric Pulmonology
Volume45
Issue number12
Early online date17 Aug 2010
DOIs
Publication statusPublished - Dec 2010

Keywords

  • asthma
  • caffeine
  • nitric oxide

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