Changing Trends in Sex Specific Prevalence Rates for Childhood Asthma, Eczema, and Hay Fever

Mustafa Osman, Nara Tagiyeva, Heather Jane Haining Wassall, Titus K. Ninan, Anne M. Devenny, Geraldine McNeill, Peter Joseph Benedict Helms, George Russell

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Abstract

Numerous surveys of school-aged children have shown increasing asthma prevalence with a less publicized but noticeable change in the male to female ratio. We sought to confirm this change in the sex ratio in four questionnaire-based surveys and investigate possible explanations. Identical questionnaire surveys were performed in 1989 (n = 3,390), 1994 (n = 4,047),1999 (n = 3,540) and 2004 (n = 1,920) in school-children aged 9-11 years. Over these 15 years the male to female ratio (M:F) significantly narrowed for wheeze (1.34 to 0.98:1 P < 0.0002), for asthma (1.74 to 1.02:1 P < 0.0001), for eczema (1.42:1 to 0.81:1 P < 0.0001) and for hay fever (1.46 to 0.93:1 P < 0.0001). The diagnosis of asthma in children with wheeze was more commonly made in boys in 1989 relative risk RR 1.32 (1.12, 1.56), even in those with accompanying eczema and/or hay fever RR 1.20 (0.99, 1.45). By 2004 this sex bias in diagnosis was no longer present, RR 1.01 (0.91,1.12) for wheeze and 1.02 (0.85,1.21) for those with wheeze and eczema and/or hay fever. From 1989 to 2004 no significant difference in sex distribution changes between older and younger children occurred, making secular trends in the onset of puberty in females an unlikely contributory factor. The disappearance of the bias to diagnose asthma in symptomatic males but not in females may be partly responsible for the narrowing of the sex ratio, but other factors such as those enhancing the expression of asthma and atopy in females may also be implicated.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalPediatric Pulmonology
Volume42
Issue number1
Early online date28 Nov 2006
DOIs
Publication statusPublished - Jan 2007

Keywords

  • asthma
  • survey
  • trends
  • epidemiology
  • sex ratio
  • sex
  • hay fever
  • eczema
  • wheeze
  • respiratory health survey
  • skin-test reactivity
  • body-mass index
  • Aberdeen schoolchildren
  • gender-differences
  • children
  • atopy
  • symptoms
  • increase
  • association

Cite this

Osman, M., Tagiyeva, N., Wassall, H. J. H., Ninan, T. K., Devenny, A. M., McNeill, G., Helms, P. J. B., & Russell, G. (2007). Changing Trends in Sex Specific Prevalence Rates for Childhood Asthma, Eczema, and Hay Fever. Pediatric Pulmonology, 42(1), 60-65. https://doi.org/10.1002/ppul.20545