Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient

G H Farrar, M A Roff, T Amin, J Ball, A M Parrett, U Battacharyya, J Booth, M H Wansbrough-Jones, P J Greenaway

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Abstract

Five HIV-1 isolates were obtained sequentially from a single seropositive individual during the later stages of AIDS. Four of these isolates were adapted to grow in a continuous human T-lymphocytic cell line. Comparative biological and biochemical studies of the virus isolates were made using persistently infected cultures or virus derived from these systems respectively. The data obtained clearly shows that viruses with different biological properties can be isolated from the same individual at different times during the course of clinical AIDS.

Original languageEnglish
Pages (from-to)104-13
Number of pages10
JournalJournal of Virology
Volume34
Issue number2
Publication statusPublished - Jun 1991

Keywords

  • Acquired Immunodeficiency Syndrome
  • Cell Line
  • Endodeoxyribonucleases
  • Giant Cells
  • HIV Envelope Protein gp120
  • HIV-1
  • Humans
  • Kinetics
  • Molecular Weight
  • Proviruses
  • Retroviridae Proteins
  • T-Lymphocytes
  • Time Factors
  • Virus Replication

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    Farrar, G. H., Roff, M. A., Amin, T., Ball, J., Parrett, A. M., Battacharyya, U., Booth, J., Wansbrough-Jones, M. H., & Greenaway, P. J. (1991). Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient. Journal of Virology, 34(2), 104-13.