Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient

G H Farrar; M A Roff; T Amin; J Ball; A M Parrett; U Battacharyya; J Booth; M H Wansbrough-Jones; P J Greenaway

Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient

G H Farrar, M A Roff, T Amin, J Ball, A M Parrett, U Battacharyya, J Booth, M H Wansbrough-Jones, P J Greenaway

Research output: Contribution to journal › Article › peer-review

Abstract

Five HIV-1 isolates were obtained sequentially from a single seropositive individual during the later stages of AIDS. Four of these isolates were adapted to grow in a continuous human T-lymphocytic cell line. Comparative biological and biochemical studies of the virus isolates were made using persistently infected cultures or virus derived from these systems respectively. The data obtained clearly shows that viruses with different biological properties can be isolated from the same individual at different times during the course of clinical AIDS.

Original language	English
Pages (from-to)	104-13
Number of pages	10
Journal	Journal of Virology
Volume	34
Issue number	2
Publication status	Published - Jun 1991

Keywords

Acquired Immunodeficiency Syndrome
Cell Line
Endodeoxyribonucleases
Giant Cells
HIV Envelope Protein gp120
HIV-1
Humans
Kinetics
Molecular Weight
Proviruses
Retroviridae Proteins
T-Lymphocytes
Time Factors
Virus Replication

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient",

abstract = "Five HIV-1 isolates were obtained sequentially from a single seropositive individual during the later stages of AIDS. Four of these isolates were adapted to grow in a continuous human T-lymphocytic cell line. Comparative biological and biochemical studies of the virus isolates were made using persistently infected cultures or virus derived from these systems respectively. The data obtained clearly shows that viruses with different biological properties can be isolated from the same individual at different times during the course of clinical AIDS.",

keywords = "Acquired Immunodeficiency Syndrome, Cell Line, Endodeoxyribonucleases, Giant Cells, HIV Envelope Protein gp120, HIV-1, Humans, Kinetics, Molecular Weight, Proviruses, Retroviridae Proteins, T-Lymphocytes, Time Factors, Virus Replication",

author = "Farrar, {G H} and Roff, {M A} and T Amin and J Ball and Parrett, {A M} and U Battacharyya and J Booth and Wansbrough-Jones, {M H} and Greenaway, {P J}",

year = "1991",

month = jun,

language = "English",

volume = "34",

pages = "104--13",

journal = "Journal of Virology",

issn = "0146-6615",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient

AU - Farrar, G H

AU - Roff, M A

AU - Amin, T

AU - Ball, J

AU - Parrett, A M

AU - Battacharyya, U

AU - Booth, J

AU - Wansbrough-Jones, M H

AU - Greenaway, P J

PY - 1991/6

Y1 - 1991/6

N2 - Five HIV-1 isolates were obtained sequentially from a single seropositive individual during the later stages of AIDS. Four of these isolates were adapted to grow in a continuous human T-lymphocytic cell line. Comparative biological and biochemical studies of the virus isolates were made using persistently infected cultures or virus derived from these systems respectively. The data obtained clearly shows that viruses with different biological properties can be isolated from the same individual at different times during the course of clinical AIDS.

AB - Five HIV-1 isolates were obtained sequentially from a single seropositive individual during the later stages of AIDS. Four of these isolates were adapted to grow in a continuous human T-lymphocytic cell line. Comparative biological and biochemical studies of the virus isolates were made using persistently infected cultures or virus derived from these systems respectively. The data obtained clearly shows that viruses with different biological properties can be isolated from the same individual at different times during the course of clinical AIDS.

KW - Acquired Immunodeficiency Syndrome

KW - Cell Line

KW - Endodeoxyribonucleases

KW - Giant Cells

KW - HIV Envelope Protein gp120

KW - HIV-1

KW - Humans

KW - Kinetics

KW - Molecular Weight

KW - Proviruses

KW - Retroviridae Proteins

KW - T-Lymphocytes

KW - Time Factors

KW - Virus Replication

M3 - Article

C2 - 1890410

SN - 0146-6615

VL - 34

SP - 104

EP - 113

JO - Journal of Virology

JF - Journal of Virology

IS - 2

ER -

Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient

Abstract

Keywords

UN SDGs

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