Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient

G H Farrar, M A Roff, T Amin, J Ball, A M Parrett, U Battacharyya, J Booth, M H Wansbrough-Jones, P J Greenaway

Research output: Contribution to journalArticle

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Abstract

Five HIV-1 isolates were obtained sequentially from a single seropositive individual during the later stages of AIDS. Four of these isolates were adapted to grow in a continuous human T-lymphocytic cell line. Comparative biological and biochemical studies of the virus isolates were made using persistently infected cultures or virus derived from these systems respectively. The data obtained clearly shows that viruses with different biological properties can be isolated from the same individual at different times during the course of clinical AIDS.

Original languageEnglish
Pages (from-to)104-13
Number of pages10
JournalJournal of Virology
Volume34
Issue number2
Publication statusPublished - Jun 1991

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Human immunodeficiency virus
HIV
Viruses
viruses
Acquired Immunodeficiency Syndrome
Human immunodeficiency virus 1
disease course
HIV-1
cell lines
Cell Line

Keywords

  • Acquired Immunodeficiency Syndrome
  • Cell Line
  • Endodeoxyribonucleases
  • Giant Cells
  • HIV Envelope Protein gp120
  • HIV-1
  • Humans
  • Kinetics
  • Molecular Weight
  • Proviruses
  • Retroviridae Proteins
  • T-Lymphocytes
  • Time Factors
  • Virus Replication

Cite this

Farrar, G. H., Roff, M. A., Amin, T., Ball, J., Parrett, A. M., Battacharyya, U., ... Greenaway, P. J. (1991). Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient. Journal of Virology, 34(2), 104-13.

Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient. / Farrar, G H; Roff, M A; Amin, T; Ball, J; Parrett, A M; Battacharyya, U; Booth, J; Wansbrough-Jones, M H; Greenaway, P J.

In: Journal of Virology, Vol. 34, No. 2, 06.1991, p. 104-13.

Research output: Contribution to journalArticle

Farrar, GH, Roff, MA, Amin, T, Ball, J, Parrett, AM, Battacharyya, U, Booth, J, Wansbrough-Jones, MH & Greenaway, PJ 1991, 'Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient', Journal of Virology, vol. 34, no. 2, pp. 104-13.
Farrar, G H ; Roff, M A ; Amin, T ; Ball, J ; Parrett, A M ; Battacharyya, U ; Booth, J ; Wansbrough-Jones, M H ; Greenaway, P J. / Characterisation of a series of human immunodeficiency virus isolates derived sequentially from a single patient. In: Journal of Virology. 1991 ; Vol. 34, No. 2. pp. 104-13.
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