Characteristics of neuronal lipofuscin in the superior temporal gyrus in Alzheimers disease do not differ from non-diseased controls

a comparison with disease-related changes in the superior frontal gyrus

C.Q. Mountjoy, J. H. Dowson, Charles Robert Harrington, M. R. Cairns, H. Wilton-Cox

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Neuronal lipofuscin characteristics in the superior temporal gyrus from 21 patients with Alzheimer's disease (AD) and from 18 age-matched non-diseased subjects were compared with previously reported findings from the superior frontal gyrus. A discriminant function analysis of lipofuscin characteristics in the superior temporal gyrus did not provide a significant predictive level for cases whose diagnoses were correctly classified (56.4%, P=0.63). In contrast, AD-related decrease in the number of smaller lipofuscin regions in the neurons of the frontal gyrus was confirmed, and the same analysis of lipofuscin characteristics in this region gave a significant predictive level for membership of the AD group of 86.6% (P < 0.001). The findings indicate that changes in neuronal lipofuscin related to AD, which may reflect an increased rate of lipofuscin formation, show differences between neocortical regions. This study provides additional information on the distribution of neuropathological characteristics in AD.

Original languageEnglish
Pages (from-to)490-496
Number of pages7
JournalActa Neuropathologica
Volume109
Issue number5
DOIs
Publication statusPublished - May 2005

Keywords

  • Alzheimer's disease
  • lipofuscin
  • neocortex
  • amyloid-beta-protein
  • senile dementia
  • iintraneuronal lipopigment
  • neurofibrillary tangles
  • laminar distribution
  • cell-death
  • brain
  • plaques
  • cortex
  • degeneration

Cite this

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title = "Characteristics of neuronal lipofuscin in the superior temporal gyrus in Alzheimers disease do not differ from non-diseased controls: a comparison with disease-related changes in the superior frontal gyrus",
abstract = "Neuronal lipofuscin characteristics in the superior temporal gyrus from 21 patients with Alzheimer's disease (AD) and from 18 age-matched non-diseased subjects were compared with previously reported findings from the superior frontal gyrus. A discriminant function analysis of lipofuscin characteristics in the superior temporal gyrus did not provide a significant predictive level for cases whose diagnoses were correctly classified (56.4{\%}, P=0.63). In contrast, AD-related decrease in the number of smaller lipofuscin regions in the neurons of the frontal gyrus was confirmed, and the same analysis of lipofuscin characteristics in this region gave a significant predictive level for membership of the AD group of 86.6{\%} (P < 0.001). The findings indicate that changes in neuronal lipofuscin related to AD, which may reflect an increased rate of lipofuscin formation, show differences between neocortical regions. This study provides additional information on the distribution of neuropathological characteristics in AD.",
keywords = "Alzheimer's disease, lipofuscin, neocortex, amyloid-beta-protein, senile dementia, iintraneuronal lipopigment, neurofibrillary tangles, laminar distribution, cell-death, brain, plaques, cortex, degeneration",
author = "C.Q. Mountjoy and Dowson, {J. H.} and Harrington, {Charles Robert} and Cairns, {M. R.} and H. Wilton-Cox",
year = "2005",
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doi = "10.1007/s00401-005-0993-9",
language = "English",
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pages = "490--496",
journal = "Acta Neuropathologica",
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TY - JOUR

T1 - Characteristics of neuronal lipofuscin in the superior temporal gyrus in Alzheimers disease do not differ from non-diseased controls

T2 - a comparison with disease-related changes in the superior frontal gyrus

AU - Mountjoy, C.Q.

AU - Dowson, J. H.

AU - Harrington, Charles Robert

AU - Cairns, M. R.

AU - Wilton-Cox, H.

PY - 2005/5

Y1 - 2005/5

N2 - Neuronal lipofuscin characteristics in the superior temporal gyrus from 21 patients with Alzheimer's disease (AD) and from 18 age-matched non-diseased subjects were compared with previously reported findings from the superior frontal gyrus. A discriminant function analysis of lipofuscin characteristics in the superior temporal gyrus did not provide a significant predictive level for cases whose diagnoses were correctly classified (56.4%, P=0.63). In contrast, AD-related decrease in the number of smaller lipofuscin regions in the neurons of the frontal gyrus was confirmed, and the same analysis of lipofuscin characteristics in this region gave a significant predictive level for membership of the AD group of 86.6% (P < 0.001). The findings indicate that changes in neuronal lipofuscin related to AD, which may reflect an increased rate of lipofuscin formation, show differences between neocortical regions. This study provides additional information on the distribution of neuropathological characteristics in AD.

AB - Neuronal lipofuscin characteristics in the superior temporal gyrus from 21 patients with Alzheimer's disease (AD) and from 18 age-matched non-diseased subjects were compared with previously reported findings from the superior frontal gyrus. A discriminant function analysis of lipofuscin characteristics in the superior temporal gyrus did not provide a significant predictive level for cases whose diagnoses were correctly classified (56.4%, P=0.63). In contrast, AD-related decrease in the number of smaller lipofuscin regions in the neurons of the frontal gyrus was confirmed, and the same analysis of lipofuscin characteristics in this region gave a significant predictive level for membership of the AD group of 86.6% (P < 0.001). The findings indicate that changes in neuronal lipofuscin related to AD, which may reflect an increased rate of lipofuscin formation, show differences between neocortical regions. This study provides additional information on the distribution of neuropathological characteristics in AD.

KW - Alzheimer's disease

KW - lipofuscin

KW - neocortex

KW - amyloid-beta-protein

KW - senile dementia

KW - iintraneuronal lipopigment

KW - neurofibrillary tangles

KW - laminar distribution

KW - cell-death

KW - brain

KW - plaques

KW - cortex

KW - degeneration

U2 - 10.1007/s00401-005-0993-9

DO - 10.1007/s00401-005-0993-9

M3 - Article

VL - 109

SP - 490

EP - 496

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 5

ER -