Characterization of a class II ketol-acid reductoisomerase from Mycobacterium tuberculosis

Ane Valera, Shan Wang, Reuben Carr, Laurent Trembleau, Hai Deng* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Mycobacterium tuberculosis ketol-acid reductoisomerases have been widely studied due to their metabolic importance towards development of drug-resistant bacteria treatment. We here report the biochemical characterization of a new KARI (MtKARI-II) from a Mycobacterium tuberculosis variant with a similar kinetic profile to class I KARIs. Phylogenetic analysis suggested that MtKARI-II is clustered into a class II KARI superfamily.

Original languageEnglish
Pages (from-to)10540-10544
Number of pages5
JournalRSC Advances
Volume12
Issue number17
Early online date6 Apr 2022
DOIs
Publication statusPublished - 2022

Keywords

  • ACETOHYDROXYACID SYNTHASE
  • INHIBITORS
  • TARGET

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