@article{79610b255b5c4dbb91297a7a3a77e383,
title = "Characterization of a class II ketol-acid reductoisomerase from Mycobacterium tuberculosis",
abstract = "Mycobacterium tuberculosis ketol-acid reductoisomerases have been widely studied due to their metabolic importance towards development of drug-resistant bacteria treatment. We here report the biochemical characterization of a new KARI (MtKARI-II) from a Mycobacterium tuberculosis variant with a similar kinetic profile to class I KARIs. Phylogenetic analysis suggested that MtKARI-II is clustered into a class II KARI superfamily.",
keywords = "ACETOHYDROXYACID SYNTHASE, INHIBITORS, TARGET",
author = "Ane Valera and Shan Wang and Reuben Carr and Laurent Trembleau and Hai Deng",
note = "This work received financial support from Biotechnology and Biological Sciences Research Council UK (A. V. and H. D., BB/R50547X/1. S. W. and H. D. BB/R00479X/1 and BB/P00380X/1), Scottish Funding Council Covid 19 Grant extension and Bridging Fund (S. W. and H. D.); UKRI Covid-19 Extension Allocation Fund (S. W. and H. D.). Funding Information: This work received financial support from Biotechnology and Biological Sciences Research Council UK (A. V. and H. D., BB/R50547X/1. S. W. and H. D. BB/R00479X/1 and BB/P00380X/1), Scottish Funding Council Covid 19 Grant extension and Bridging Fund (S. W. and H. D.); UKRI Covid-19 Extension Allocation Fund (S. W. and H. D.). Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry",
year = "2022",
doi = "10.1039/D1RA08876A",
language = "English",
volume = "12",
pages = "10540--10544",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "17",
}
