Characterization of a class II ketol-acid reductoisomerase from Mycobacterium tuberculosis

Ane Valera, Shan Wang, Reuben Carr, Laurent Trembleau, Hai Deng* (Corresponding Author)

*Corresponding author for this work

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Abstract

Mycobacterium tuberculosis ketol-acid reductoisomerases have been widely studied due to their metabolic importance towards development of drug-resistant bacteria treatment. We here report the biochemical characterization of a new KARI (MtKARI-II) from a Mycobacterium tuberculosis variant with a similar kinetic profile to class I KARIs. Phylogenetic analysis suggested that MtKARI-II is clustered into a class II KARI superfamily.

Original languageEnglish
Pages (from-to)10540-10544
Number of pages5
JournalRSC Advances
Volume12
Issue number17
Early online date6 Apr 2022
DOIs
Publication statusPublished - 2022

Bibliographical note

This work received financial support from Biotechnology and Biological Sciences Research Council UK (A. V. and H. D., BB/R50547X/1. S. W. and H. D. BB/R00479X/1 and BB/P00380X/1), Scottish Funding Council Covid 19 Grant extension and Bridging Fund (S. W. and H. D.); UKRI Covid-19 Extension Allocation Fund (S. W. and H. D.).



Funding Information:
This work received financial support from Biotechnology and Biological Sciences Research Council UK (A. V. and H. D., BB/R50547X/1. S. W. and H. D. BB/R00479X/1 and BB/P00380X/1), Scottish Funding Council Covid 19 Grant extension and Bridging Fund (S. W. and H. D.); UKRI Covid-19 Extension Allocation Fund (S. W. and H. D.).

Publisher Copyright:
© 2022 The Royal Society of Chemistry

Keywords

  • ACETOHYDROXYACID SYNTHASE
  • INHIBITORS
  • TARGET

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