Abstract
Mycobacterium tuberculosis ketol-acid reductoisomerases have been widely studied due to their metabolic importance towards development of drug-resistant bacteria treatment. We here report the biochemical characterization of a new KARI (MtKARI-II) from a Mycobacterium tuberculosis variant with a similar kinetic profile to class I KARIs. Phylogenetic analysis suggested that MtKARI-II is clustered into a class II KARI superfamily.
Original language | English |
---|---|
Pages (from-to) | 10540-10544 |
Number of pages | 5 |
Journal | RSC Advances |
Volume | 12 |
Issue number | 17 |
Early online date | 6 Apr 2022 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
This work received financial support from Biotechnology and Biological Sciences Research Council UK (A. V. and H. D., BB/R50547X/1. S. W. and H. D. BB/R00479X/1 and BB/P00380X/1), Scottish Funding Council Covid 19 Grant extension and Bridging Fund (S. W. and H. D.); UKRI Covid-19 Extension Allocation Fund (S. W. and H. D.).Funding Information:
This work received financial support from Biotechnology and Biological Sciences Research Council UK (A. V. and H. D., BB/R50547X/1. S. W. and H. D. BB/R00479X/1 and BB/P00380X/1), Scottish Funding Council Covid 19 Grant extension and Bridging Fund (S. W. and H. D.); UKRI Covid-19 Extension Allocation Fund (S. W. and H. D.).
Publisher Copyright:
© 2022 The Royal Society of Chemistry
Keywords
- ACETOHYDROXYACID SYNTHASE
- INHIBITORS
- TARGET