Characterization of antifungal C-type lectin receptor expression on murine epithelial and endothelial cells in mucosal tissues

Mark H.T. Stappers, Christina Nikolakopoulou, Darin L. Wiesner, Raif Yuecel, Bruce S. Klein, Janet A. Willment, Gordon D. Brown*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Our data reveal that selection of enzymes for generating single cell suspensions from murine tissues influences detection of surface expression of antifungal CLRs. Using a method that most preserves receptor expression, we show that non-myeloid expression of antifungal CLRs is limited to MelLec on endothelial cells in murine mucosal tissues.
Original languageEnglish
Pages (from-to)2341-2344
Number of pages4
JournalEuropean Journal of Immunology
Volume51
Issue number9
Early online date23 Jun 2021
DOIs
Publication statusPublished - Sep 2021

Keywords

  • C-type lectin
  • Endothelial cells
  • Epithelial cells
  • Immunity, Innate

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