Characterizing dementia with Lewy bodies by means of diffusion tensor imaging

Rosie Watson, Andrew M. Blamire, Sean J. Colloby, Josh S. Wood, Robert Barber, Jiabao He, John T. O'Brien

Research output: Contribution to journalArticle

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Abstract

Objective: To investigate patterns of in vivo white matter tract change using diffusion tensor imaging (DTI), we conducted a cross-sectional study of dementia with Lewy bodies (DLB) in comparison with Alzheimer disease (AD) and normal aging.

Methods: The study included 106 subjects (35 with DLB, 36 with AD, and 35 elderly controls) who underwent clinical and neuropsychological assessment and diffusion tensor MRI. We used tract-based spatial statistics to investigate patterns of reduced fractional anisotropy (FA) and increased mean diffusivity (MD) across the entire white matter tract skeleton and also investigated correlations with clinical features.

Results: Areas of reduced FA in subjects with DLB vs controls were found primarily in parieto-occipital white matter tracts; in AD, the changes were much more diffuse. DLB was also associated with reduced FA in the pons and left thalamus, in comparison with AD. The pattern of MD increase was diffuse in AD and DLB. We found an association between DTI parameters and impaired episodic memory, letter fluency, and severity of motor parkinsonism in DLB.

Conclusions: Despite a similar level of dementia severity, patterns of DTI changes in AD and DLB differed significantly. The selective involvement of the visual association areas and subcortical structures and the significant clinical correlations highlight the potential importance of white matter tract change in the pathogenesis of DLB. DTI may be a useful technique to investigate early and possible preclinical changes in DLB and warrants further investigation.
Original languageEnglish
Pages (from-to)906-914
Number of pages9
JournalNeurology
Volume79
Issue number9
Early online date15 Aug 2012
DOIs
Publication statusPublished - 28 Aug 2012

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Lewy Body Disease
Diffusion Tensor Imaging
Alzheimer Disease
Anisotropy
Lewy Bodies
Diffusion Magnetic Resonance Imaging
Episodic Memory
Pons
Parkinsonian Disorders
Thalamus
Skeleton
Dementia
Cross-Sectional Studies
White Matter

Cite this

Watson, R., Blamire, A. M., Colloby, S. J., Wood, J. S., Barber, R., He, J., & O'Brien, J. T. (2012). Characterizing dementia with Lewy bodies by means of diffusion tensor imaging. Neurology, 79(9), 906-914. https://doi.org/10.1212/WNL.0b013e318266fc51

Characterizing dementia with Lewy bodies by means of diffusion tensor imaging. / Watson, Rosie; Blamire, Andrew M.; Colloby, Sean J.; Wood, Josh S.; Barber, Robert; He, Jiabao; O'Brien, John T.

In: Neurology, Vol. 79, No. 9, 28.08.2012, p. 906-914.

Research output: Contribution to journalArticle

Watson, R, Blamire, AM, Colloby, SJ, Wood, JS, Barber, R, He, J & O'Brien, JT 2012, 'Characterizing dementia with Lewy bodies by means of diffusion tensor imaging', Neurology, vol. 79, no. 9, pp. 906-914. https://doi.org/10.1212/WNL.0b013e318266fc51
Watson, Rosie ; Blamire, Andrew M. ; Colloby, Sean J. ; Wood, Josh S. ; Barber, Robert ; He, Jiabao ; O'Brien, John T. / Characterizing dementia with Lewy bodies by means of diffusion tensor imaging. In: Neurology. 2012 ; Vol. 79, No. 9. pp. 906-914.
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