Childhood IQ and cardiovascular disease in adulthood: prospective observational study linking the SMS 1932 and the Midspan studies

C. L. Hart, Mark Steven Taylor, G. Davey-Smith, Lawrence Jeffrey Whalley, J. M. Starr, D. J. Hole, V. Wilson, I. J. Deary

    Research output: Contribution to journalArticle

    110 Citations (Scopus)

    Abstract

    This study investigated the influence of childhood IQ on the relationships between risk factors and cardiovascular disease (CVD), coronary heart disease (CHD) and stroke in adulthood. Participants were from the Midspan prospective cohort studies which were conducted on adults in Scotland in the 1970s. Data on risk factors were collected from a questionnaire and at a screening examination, and participants were followed up for 25 years for hospital admissions and mortality. 938 Midspan participants were successfully matched with their age I I IQ from the Scottish Mental Survey 1932, in which 1921-born children attending schools in Scotland took a cognitive ability test. Childhood IQ was negatively correlated with diastolic and systolic blood pressure, and positively correlated with height and respiratory function in adulthood. For each of CVD, CHD and stroke, defined as either a hospital admission or death, there was an increased relative rate per standard deviation decrease (15 points) in childhood IQ of 1.11 (95% confidence interval 1.01-1.23), 1.16 (1.03-1.32) and 1.10 (0.88-1.36), respectively. With events divided into those first occurring before and those first occurring after the age of 65, the relationships between childhood IQ and CVD, CHD and stroke were only seen before age 65 and not after age 65. Blood pressure, height, respiratory function and smoking were associated with CVD events. Relationships were stronger in the early compared to the later period for smoking and FEV1, and stronger in the later compared to the earlier period for blood pressure. Adjustment for childhood IQ had small attenuating effects on the risk factor-CVD relationship before age 65 and no effects after age 65. Adjustment for risk factors attenuated the childhood IQ-CVD relationship by a small amount before age 65. Childhood IQ was associated with CVD risk factors and events and can be considered an important new risk factor. (C) 2004 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)2131-2138
    Number of pages7
    JournalSocial Science & Medicine
    Volume59
    DOIs
    Publication statusPublished - 2004

    Keywords

    • cardiovascular disease
    • cohort
    • mental ability
    • mortality
    • risk factors
    • Scotland
    • CORONARY-HEART-DISEASE
    • FOLLOW-UP
    • COGNITIVE FUNCTION
    • MORTALITY RISK
    • BLOOD-PRESSURE
    • BIRTH-WEIGHT
    • SOCIAL-CLASS
    • AGE
    • POPULATION
    • SMOKING

    Cite this

    Childhood IQ and cardiovascular disease in adulthood: prospective observational study linking the SMS 1932 and the Midspan studies. / Hart, C. L.; Taylor, Mark Steven; Davey-Smith, G.; Whalley, Lawrence Jeffrey; Starr, J. M.; Hole, D. J.; Wilson, V.; Deary, I. J.

    In: Social Science & Medicine, Vol. 59, 2004, p. 2131-2138.

    Research output: Contribution to journalArticle

    Hart, C. L. ; Taylor, Mark Steven ; Davey-Smith, G. ; Whalley, Lawrence Jeffrey ; Starr, J. M. ; Hole, D. J. ; Wilson, V. ; Deary, I. J. / Childhood IQ and cardiovascular disease in adulthood: prospective observational study linking the SMS 1932 and the Midspan studies. In: Social Science & Medicine. 2004 ; Vol. 59. pp. 2131-2138.
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    AB - This study investigated the influence of childhood IQ on the relationships between risk factors and cardiovascular disease (CVD), coronary heart disease (CHD) and stroke in adulthood. Participants were from the Midspan prospective cohort studies which were conducted on adults in Scotland in the 1970s. Data on risk factors were collected from a questionnaire and at a screening examination, and participants were followed up for 25 years for hospital admissions and mortality. 938 Midspan participants were successfully matched with their age I I IQ from the Scottish Mental Survey 1932, in which 1921-born children attending schools in Scotland took a cognitive ability test. Childhood IQ was negatively correlated with diastolic and systolic blood pressure, and positively correlated with height and respiratory function in adulthood. For each of CVD, CHD and stroke, defined as either a hospital admission or death, there was an increased relative rate per standard deviation decrease (15 points) in childhood IQ of 1.11 (95% confidence interval 1.01-1.23), 1.16 (1.03-1.32) and 1.10 (0.88-1.36), respectively. With events divided into those first occurring before and those first occurring after the age of 65, the relationships between childhood IQ and CVD, CHD and stroke were only seen before age 65 and not after age 65. Blood pressure, height, respiratory function and smoking were associated with CVD events. Relationships were stronger in the early compared to the later period for smoking and FEV1, and stronger in the later compared to the earlier period for blood pressure. Adjustment for childhood IQ had small attenuating effects on the risk factor-CVD relationship before age 65 and no effects after age 65. Adjustment for risk factors attenuated the childhood IQ-CVD relationship by a small amount before age 65. Childhood IQ was associated with CVD risk factors and events and can be considered an important new risk factor. (C) 2004 Elsevier Ltd. All rights reserved.

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