Childhood obesity in relation to poor asthma control and exacerbations: A meta-analysis

Fariba Ahmadizar, Susanne J H Vijverberg, Hubertus G. M. Arets, Anthonius de Boer, Jason E Lang, Meyer Kattan, Colin Palmer, Somnath Mukhopadhyay, Steve Turner, Anke Hilse Maitland-van der Zee

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Abstract

To estimate the association between obesity and poor asthma control or risk of exacerbations in asthmatic children and adolescents, and to assess whether these associations are different by sex.

A meta-analysis was performed on unpublished data from three North-European paediatric asthma cohorts (BREATHE, PACMAN (Pharmacogenetics of Asthma medication in Children: Medication with Anti-inflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies). Outcomes were poor asthma control (based on asthma symptoms) and exacerbations rates (asthma-related visits to the emergency department, asthma-related hospitalisations or use of oral corticosteroids). Overall pooled estimates of the odds ratios were obtained using fixed- or random-effects models.

In a meta-analysis of 46 070 asthmatic children and adolescents, obese children (body mass index ≥95th percentile) compared with non-obese peers had a small but significant increased risk of asthma exacerbations (OR 1.17, 95% CI 1.03–1.34; I2: 54.7%). However, there was no statistically significant association between obesity and poor asthma control (n=4973, OR 1.23, 95% CI 0.99–1.53; I2: 0.0%). After stratification for sex, the differences in odds ratios for girls and boys were similar, yet no longer statistically significant.

In asthmatic children, obesity is associated with a minor increased risk of asthma exacerbations but not with poor asthma control. Sex does not appear to modify this risk.
Original languageEnglish
Pages (from-to)1063-1073
Number of pages11
JournalEuropean Respiratory Journal
Volume48
Issue number4
DOIs
Publication statusPublished - 1 Oct 2016

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Pediatric Obesity
Meta-Analysis
Asthma
Obesity
Odds Ratio
Pediatrics
Pharmacogenetics
Sex Characteristics
Longitudinal Studies
Hospital Emergency Service
Adrenal Cortex Hormones
Hospitalization
Body Mass Index
Anti-Inflammatory Agents
Cross-Sectional Studies

Keywords

  • body mass index
  • overweight
  • children
  • asthma severity

Cite this

Ahmadizar, F., Vijverberg, S. J. H., Arets, H. G. M., de Boer, A., Lang, J. E., Kattan, M., ... Maitland-van der Zee, A. H. (2016). Childhood obesity in relation to poor asthma control and exacerbations: A meta-analysis. European Respiratory Journal, 48(4), 1063-1073. https://doi.org/10.1183/13993003.00766-2016

Childhood obesity in relation to poor asthma control and exacerbations : A meta-analysis. / Ahmadizar, Fariba; Vijverberg, Susanne J H; Arets, Hubertus G. M.; de Boer, Anthonius; Lang, Jason E; Kattan, Meyer; Palmer, Colin; Mukhopadhyay, Somnath; Turner, Steve; Maitland-van der Zee, Anke Hilse.

In: European Respiratory Journal, Vol. 48, No. 4, 01.10.2016, p. 1063-1073.

Research output: Contribution to journalArticle

Ahmadizar, F, Vijverberg, SJH, Arets, HGM, de Boer, A, Lang, JE, Kattan, M, Palmer, C, Mukhopadhyay, S, Turner, S & Maitland-van der Zee, AH 2016, 'Childhood obesity in relation to poor asthma control and exacerbations: A meta-analysis', European Respiratory Journal, vol. 48, no. 4, pp. 1063-1073. https://doi.org/10.1183/13993003.00766-2016
Ahmadizar F, Vijverberg SJH, Arets HGM, de Boer A, Lang JE, Kattan M et al. Childhood obesity in relation to poor asthma control and exacerbations: A meta-analysis. European Respiratory Journal. 2016 Oct 1;48(4):1063-1073. https://doi.org/10.1183/13993003.00766-2016
Ahmadizar, Fariba ; Vijverberg, Susanne J H ; Arets, Hubertus G. M. ; de Boer, Anthonius ; Lang, Jason E ; Kattan, Meyer ; Palmer, Colin ; Mukhopadhyay, Somnath ; Turner, Steve ; Maitland-van der Zee, Anke Hilse. / Childhood obesity in relation to poor asthma control and exacerbations : A meta-analysis. In: European Respiratory Journal. 2016 ; Vol. 48, No. 4. pp. 1063-1073.
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