Choice between reinforcer delays versus choice between reinforcer magnitudes

differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core

S da Costa Araújo, S Body, L Valencia-Torres, C M Olarte Sanchez, V K Bak, J F W Deakin, I M Anderson, C M Bradshaw, E Szabadi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Lesions of the orbital prefrontal cortex (OPFC) and the nucleus accumbens core (AcbC) can disrupt performance in inter-temporal choice tasks, possibly by increasing the organism's sensitivity to delay and/or magnitude of reinforcement. This experiment examined whether exposure to an inter-temporal choice would induce neuronal activation in these areas, as indicated by enhanced expression of the Fos protein. Twelve rats were trained to press levers A and B under an adjusting-delay schedule in which a response on A delivered 50 microl of a sucrose reinforcer after 2 or 18s, whereas a response on B delivered the same reinforcer after a delay that was adjusted in accordance with the rat's choices. Another 12 rats were trained under a similar schedule in which a response on A delivered an immediate reinforcer of size 20 or 180 microl, whereas a response on B delivered an immediate reinforcer whose size was adjusted in accordance with the rat's choices. A third group received training under a schedule that did not entail variation of reinforcer size or delay, or choice between reinforcers, and a control group underwent food restriction without behavioural training. Exposure to the adjusting-delay schedule was associated with enhanced Fos expression in both the OPFC and AcbC, whereas exposure to the adjusting-magnitude schedule was associated with enhanced Fos expression in the OPFC but not the AcbC, compared to the control group. The results are consistent with previous findings that implicated the AcbC and OPFC in delay discounting, and the OPFC in sensitivity to reinforcer size.
Original languageEnglish
Pages (from-to)269-277
Number of pages9
JournalBehavioural Brain Research
Volume213
Issue number2
Early online date16 May 2010
DOIs
Publication statusPublished - 1 Dec 2010

Fingerprint

Nucleus Accumbens
Prefrontal Cortex
Appointments and Schedules
Control Groups
Sucrose
Food

Keywords

  • animals
  • choice behavior
  • conditioning, operant
  • female
  • nucleus accumbens
  • prefrontal cortex
  • proto-oncogene proteins c-fos
  • rats
  • rats, wistar
  • reinforcement (psychology)
  • reinforcement schedule
  • time factors

Cite this

Choice between reinforcer delays versus choice between reinforcer magnitudes : differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core. / da Costa Araújo, S; Body, S; Valencia-Torres, L; Olarte Sanchez, C M; Bak, V K; Deakin, J F W; Anderson, I M; Bradshaw, C M; Szabadi, E.

In: Behavioural Brain Research, Vol. 213, No. 2, 01.12.2010, p. 269-277.

Research output: Contribution to journalArticle

da Costa Araújo, S, Body, S, Valencia-Torres, L, Olarte Sanchez, CM, Bak, VK, Deakin, JFW, Anderson, IM, Bradshaw, CM & Szabadi, E 2010, 'Choice between reinforcer delays versus choice between reinforcer magnitudes: differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core', Behavioural Brain Research, vol. 213, no. 2, pp. 269-277. https://doi.org/10.1016/j.bbr.2010.05.014
da Costa Araújo, S ; Body, S ; Valencia-Torres, L ; Olarte Sanchez, C M ; Bak, V K ; Deakin, J F W ; Anderson, I M ; Bradshaw, C M ; Szabadi, E. / Choice between reinforcer delays versus choice between reinforcer magnitudes : differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core. In: Behavioural Brain Research. 2010 ; Vol. 213, No. 2. pp. 269-277.
@article{f445c74d615c41839f1e938dd13291f1,
title = "Choice between reinforcer delays versus choice between reinforcer magnitudes: differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core",
abstract = "Lesions of the orbital prefrontal cortex (OPFC) and the nucleus accumbens core (AcbC) can disrupt performance in inter-temporal choice tasks, possibly by increasing the organism's sensitivity to delay and/or magnitude of reinforcement. This experiment examined whether exposure to an inter-temporal choice would induce neuronal activation in these areas, as indicated by enhanced expression of the Fos protein. Twelve rats were trained to press levers A and B under an adjusting-delay schedule in which a response on A delivered 50 microl of a sucrose reinforcer after 2 or 18s, whereas a response on B delivered the same reinforcer after a delay that was adjusted in accordance with the rat's choices. Another 12 rats were trained under a similar schedule in which a response on A delivered an immediate reinforcer of size 20 or 180 microl, whereas a response on B delivered an immediate reinforcer whose size was adjusted in accordance with the rat's choices. A third group received training under a schedule that did not entail variation of reinforcer size or delay, or choice between reinforcers, and a control group underwent food restriction without behavioural training. Exposure to the adjusting-delay schedule was associated with enhanced Fos expression in both the OPFC and AcbC, whereas exposure to the adjusting-magnitude schedule was associated with enhanced Fos expression in the OPFC but not the AcbC, compared to the control group. The results are consistent with previous findings that implicated the AcbC and OPFC in delay discounting, and the OPFC in sensitivity to reinforcer size.",
keywords = "animals, choice behavior, conditioning, operant, female, nucleus accumbens, prefrontal cortex, proto-oncogene proteins c-fos, rats, rats, wistar, reinforcement (psychology), reinforcement schedule, time factors",
author = "{da Costa Ara{\'u}jo}, S and S Body and L Valencia-Torres and {Olarte Sanchez}, {C M} and Bak, {V K} and Deakin, {J F W} and Anderson, {I M} and Bradshaw, {C M} and E Szabadi",
note = "Copyright (c) 2010 Elsevier B.V. All rights reserved.",
year = "2010",
month = "12",
day = "1",
doi = "10.1016/j.bbr.2010.05.014",
language = "English",
volume = "213",
pages = "269--277",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Choice between reinforcer delays versus choice between reinforcer magnitudes

T2 - differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core

AU - da Costa Araújo, S

AU - Body, S

AU - Valencia-Torres, L

AU - Olarte Sanchez, C M

AU - Bak, V K

AU - Deakin, J F W

AU - Anderson, I M

AU - Bradshaw, C M

AU - Szabadi, E

N1 - Copyright (c) 2010 Elsevier B.V. All rights reserved.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Lesions of the orbital prefrontal cortex (OPFC) and the nucleus accumbens core (AcbC) can disrupt performance in inter-temporal choice tasks, possibly by increasing the organism's sensitivity to delay and/or magnitude of reinforcement. This experiment examined whether exposure to an inter-temporal choice would induce neuronal activation in these areas, as indicated by enhanced expression of the Fos protein. Twelve rats were trained to press levers A and B under an adjusting-delay schedule in which a response on A delivered 50 microl of a sucrose reinforcer after 2 or 18s, whereas a response on B delivered the same reinforcer after a delay that was adjusted in accordance with the rat's choices. Another 12 rats were trained under a similar schedule in which a response on A delivered an immediate reinforcer of size 20 or 180 microl, whereas a response on B delivered an immediate reinforcer whose size was adjusted in accordance with the rat's choices. A third group received training under a schedule that did not entail variation of reinforcer size or delay, or choice between reinforcers, and a control group underwent food restriction without behavioural training. Exposure to the adjusting-delay schedule was associated with enhanced Fos expression in both the OPFC and AcbC, whereas exposure to the adjusting-magnitude schedule was associated with enhanced Fos expression in the OPFC but not the AcbC, compared to the control group. The results are consistent with previous findings that implicated the AcbC and OPFC in delay discounting, and the OPFC in sensitivity to reinforcer size.

AB - Lesions of the orbital prefrontal cortex (OPFC) and the nucleus accumbens core (AcbC) can disrupt performance in inter-temporal choice tasks, possibly by increasing the organism's sensitivity to delay and/or magnitude of reinforcement. This experiment examined whether exposure to an inter-temporal choice would induce neuronal activation in these areas, as indicated by enhanced expression of the Fos protein. Twelve rats were trained to press levers A and B under an adjusting-delay schedule in which a response on A delivered 50 microl of a sucrose reinforcer after 2 or 18s, whereas a response on B delivered the same reinforcer after a delay that was adjusted in accordance with the rat's choices. Another 12 rats were trained under a similar schedule in which a response on A delivered an immediate reinforcer of size 20 or 180 microl, whereas a response on B delivered an immediate reinforcer whose size was adjusted in accordance with the rat's choices. A third group received training under a schedule that did not entail variation of reinforcer size or delay, or choice between reinforcers, and a control group underwent food restriction without behavioural training. Exposure to the adjusting-delay schedule was associated with enhanced Fos expression in both the OPFC and AcbC, whereas exposure to the adjusting-magnitude schedule was associated with enhanced Fos expression in the OPFC but not the AcbC, compared to the control group. The results are consistent with previous findings that implicated the AcbC and OPFC in delay discounting, and the OPFC in sensitivity to reinforcer size.

KW - animals

KW - choice behavior

KW - conditioning, operant

KW - female

KW - nucleus accumbens

KW - prefrontal cortex

KW - proto-oncogene proteins c-fos

KW - rats

KW - rats, wistar

KW - reinforcement (psychology)

KW - reinforcement schedule

KW - time factors

U2 - 10.1016/j.bbr.2010.05.014

DO - 10.1016/j.bbr.2010.05.014

M3 - Article

VL - 213

SP - 269

EP - 277

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -