Choice between reinforcer delays versus choice between reinforcer magnitudes: differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core

S da Costa Araújo, S Body, L Valencia-Torres, C M Olarte Sanchez, V K Bak, J F W Deakin, I M Anderson, C M Bradshaw, E Szabadi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Lesions of the orbital prefrontal cortex (OPFC) and the nucleus accumbens core (AcbC) can disrupt performance in inter-temporal choice tasks, possibly by increasing the organism's sensitivity to delay and/or magnitude of reinforcement. This experiment examined whether exposure to an inter-temporal choice would induce neuronal activation in these areas, as indicated by enhanced expression of the Fos protein. Twelve rats were trained to press levers A and B under an adjusting-delay schedule in which a response on A delivered 50 microl of a sucrose reinforcer after 2 or 18s, whereas a response on B delivered the same reinforcer after a delay that was adjusted in accordance with the rat's choices. Another 12 rats were trained under a similar schedule in which a response on A delivered an immediate reinforcer of size 20 or 180 microl, whereas a response on B delivered an immediate reinforcer whose size was adjusted in accordance with the rat's choices. A third group received training under a schedule that did not entail variation of reinforcer size or delay, or choice between reinforcers, and a control group underwent food restriction without behavioural training. Exposure to the adjusting-delay schedule was associated with enhanced Fos expression in both the OPFC and AcbC, whereas exposure to the adjusting-magnitude schedule was associated with enhanced Fos expression in the OPFC but not the AcbC, compared to the control group. The results are consistent with previous findings that implicated the AcbC and OPFC in delay discounting, and the OPFC in sensitivity to reinforcer size.
Original languageEnglish
Pages (from-to)269-277
Number of pages9
JournalBehavioural Brain Research
Volume213
Issue number2
Early online date16 May 2010
DOIs
Publication statusPublished - 1 Dec 2010

Keywords

  • animals
  • choice behavior
  • conditioning, operant
  • female
  • nucleus accumbens
  • prefrontal cortex
  • proto-oncogene proteins c-fos
  • rats
  • rats, wistar
  • reinforcement (psychology)
  • reinforcement schedule
  • time factors

Fingerprint Dive into the research topics of 'Choice between reinforcer delays versus choice between reinforcer magnitudes: differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core'. Together they form a unique fingerprint.

  • Cite this

    da Costa Araújo, S., Body, S., Valencia-Torres, L., Olarte Sanchez, C. M., Bak, V. K., Deakin, J. F. W., Anderson, I. M., Bradshaw, C. M., & Szabadi, E. (2010). Choice between reinforcer delays versus choice between reinforcer magnitudes: differential Fos expression in the orbital prefrontal cortex and nucleus accumbens core. Behavioural Brain Research, 213(2), 269-277. https://doi.org/10.1016/j.bbr.2010.05.014