Choosing appropriate patient-reported outcomes instrument for glaucoma research: a systematic review of vision instruments

Jemaima Che Hamzah, Jennifer M Burr, Craig R Ramsay, Augusto Azuara-Blanco, Maria Prior

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)
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PURPOSE: To identify vision Patient-Reported Outcomes instruments relevant to glaucoma and assess their content validity. METHODS: MEDLINE, MEDLINE in Process, EMBASE and SCOPUS (to January 2009) were systematically searched. Observational studies or randomised controlled trials, published in English, reporting use of vision instruments in glaucoma studies involving adults were included. In addition, reference lists were scanned to identify additional studies describing development and/or validation to ascertain the final version of the instruments. Instruments' content was then mapped onto a theoretical framework, the World Health Organization International Classification of Functioning, Disability and Health. Two reviewers independently evaluated studies for inclusion and quality assessed instrument content. RESULTS: Thirty-three instruments were identified. Instruments were categorised into thirteen vision status, two vision disability, one vision satisfaction, five glaucoma status, one glaucoma medication related to health status, five glaucoma medication side effects and six glaucoma medication satisfaction measures according to each instruments' content. The National Eye Institute Visual Function Questionnaire-25, Impact of Vision Impairment and Treatment Satisfaction Survey-Intraocular Pressure had the highest number of positive ratings in the content validity assessment. CONCLUSION: This study provides a descriptive catalogue of vision-specific PRO instruments, to inform the choice of an appropriate measure of patient-reported outcomes in a glaucoma context.
Original languageEnglish
Pages (from-to)1141-1158
Number of pages18
JournalQuality of Life Research
Issue number7
Early online date4 Jan 2011
Publication statusPublished - Sep 2011


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