Chronic preoperative pain and psychological robustness predict acute postoperative pain outcomes after surgery for breast cancer

J. Bruce*, A. J. Thornton, Neil William Scott, S. Marfizo, R. Powell, M. Johnston, M. Wells, S. D. Heys, A. M. Thompson, Recovery Study Grp

*Corresponding author for this work

Research output: Contribution to journalArticle

45 Citations (Scopus)
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Abstract

BACKGROUND: Few epidemiological studies have prospectively investigated preoperative and surgical risk factors for acute postoperative pain after surgery for breast cancer. We investigated demographic, psychological, pain-related and surgical risk factors in women undergoing resectional surgery for breast cancer.

METHODS: Primary outcomes were pain severity, at rest (PAR) and movement-evoked pain (MEP), in the first postoperative week.

RESULTS: In 338 women undergoing surgery, those with chronic preoperative pain were three times more likely to report moderate to severe MEP after breast cancer surgery (OR 3.18, 95% CI 1.45-6.99). Increased psychological 'robustness', a composite variable representing positive affect and dispositional optimism, was associated with lower intensity acute postoperative PAR (OR 0.63, 95% CI 0.48-0.82) and MEP (OR 0.71, 95% CI 0.54-0.93). Sentinel lymph node biopsy (SLNB) and intraoperative nerve division were associated with reduced postoperative pain. No relationship was found between preoperative neuropathic pain and acute pain outcomes; altered sensations and numbness postoperatively were more common after axillary sample or clearance compared with SLNB.

CONCLUSION: Chronic preoperative pain, axillary surgery and psychological robustness significantly predicted acute pain outcomes after surgery for breast cancer. Preoperative identification and targeted intervention of subgroups at risk could enhance the recovery trajectory in cancer survivors. British Journal of Cancer (2012) 107, 937-946. doi:10.1038/bjc.2012.341 www.bjcancer.com Published online 31 July 2012 (C) 2012 Cancer Research UK

Original languageEnglish
Pages (from-to)937-946
Number of pages10
JournalBritish Journal of Cancer
Volume107
Issue number6
Early online date31 Jul 2012
DOIs
Publication statusPublished - 4 Sep 2012

Fingerprint

Acute Pain
Postoperative Pain
Chronic Pain
Breast Neoplasms
Psychology
Pain
Sentinel Lymph Node Biopsy
Neoplasms
Hypesthesia
Neuralgia
Survivors
Epidemiologic Studies
Demography
Research

Keywords

  • postoperative pain
  • acute pain
  • breast cancer surgery
  • psychological factors
  • persistent postsurgical pain
  • lymph-node dissection
  • neuropathic pain
  • risk-factors
  • dispositional optimism
  • questionnaire
  • prevalence
  • survivors
  • cohort
  • validation

Cite this

Chronic preoperative pain and psychological robustness predict acute postoperative pain outcomes after surgery for breast cancer. / Bruce, J.; Thornton, A. J.; Scott, Neil William; Marfizo, S.; Powell, R.; Johnston, M.; Wells, M.; Heys, S. D.; Thompson, A. M.; Recovery Study Grp.

In: British Journal of Cancer, Vol. 107, No. 6, 04.09.2012, p. 937-946.

Research output: Contribution to journalArticle

Bruce, J. ; Thornton, A. J. ; Scott, Neil William ; Marfizo, S. ; Powell, R. ; Johnston, M. ; Wells, M. ; Heys, S. D. ; Thompson, A. M. ; Recovery Study Grp. / Chronic preoperative pain and psychological robustness predict acute postoperative pain outcomes after surgery for breast cancer. In: British Journal of Cancer. 2012 ; Vol. 107, No. 6. pp. 937-946.
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abstract = "BACKGROUND: Few epidemiological studies have prospectively investigated preoperative and surgical risk factors for acute postoperative pain after surgery for breast cancer. We investigated demographic, psychological, pain-related and surgical risk factors in women undergoing resectional surgery for breast cancer.METHODS: Primary outcomes were pain severity, at rest (PAR) and movement-evoked pain (MEP), in the first postoperative week.RESULTS: In 338 women undergoing surgery, those with chronic preoperative pain were three times more likely to report moderate to severe MEP after breast cancer surgery (OR 3.18, 95{\%} CI 1.45-6.99). Increased psychological 'robustness', a composite variable representing positive affect and dispositional optimism, was associated with lower intensity acute postoperative PAR (OR 0.63, 95{\%} CI 0.48-0.82) and MEP (OR 0.71, 95{\%} CI 0.54-0.93). Sentinel lymph node biopsy (SLNB) and intraoperative nerve division were associated with reduced postoperative pain. No relationship was found between preoperative neuropathic pain and acute pain outcomes; altered sensations and numbness postoperatively were more common after axillary sample or clearance compared with SLNB.CONCLUSION: Chronic preoperative pain, axillary surgery and psychological robustness significantly predicted acute pain outcomes after surgery for breast cancer. Preoperative identification and targeted intervention of subgroups at risk could enhance the recovery trajectory in cancer survivors. British Journal of Cancer (2012) 107, 937-946. doi:10.1038/bjc.2012.341 www.bjcancer.com Published online 31 July 2012 (C) 2012 Cancer Research UK",
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AU - Thornton, A. J.

AU - Scott, Neil William

AU - Marfizo, S.

AU - Powell, R.

AU - Johnston, M.

AU - Wells, M.

AU - Heys, S. D.

AU - Thompson, A. M.

AU - Recovery Study Grp

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N2 - BACKGROUND: Few epidemiological studies have prospectively investigated preoperative and surgical risk factors for acute postoperative pain after surgery for breast cancer. We investigated demographic, psychological, pain-related and surgical risk factors in women undergoing resectional surgery for breast cancer.METHODS: Primary outcomes were pain severity, at rest (PAR) and movement-evoked pain (MEP), in the first postoperative week.RESULTS: In 338 women undergoing surgery, those with chronic preoperative pain were three times more likely to report moderate to severe MEP after breast cancer surgery (OR 3.18, 95% CI 1.45-6.99). Increased psychological 'robustness', a composite variable representing positive affect and dispositional optimism, was associated with lower intensity acute postoperative PAR (OR 0.63, 95% CI 0.48-0.82) and MEP (OR 0.71, 95% CI 0.54-0.93). Sentinel lymph node biopsy (SLNB) and intraoperative nerve division were associated with reduced postoperative pain. No relationship was found between preoperative neuropathic pain and acute pain outcomes; altered sensations and numbness postoperatively were more common after axillary sample or clearance compared with SLNB.CONCLUSION: Chronic preoperative pain, axillary surgery and psychological robustness significantly predicted acute pain outcomes after surgery for breast cancer. Preoperative identification and targeted intervention of subgroups at risk could enhance the recovery trajectory in cancer survivors. British Journal of Cancer (2012) 107, 937-946. doi:10.1038/bjc.2012.341 www.bjcancer.com Published online 31 July 2012 (C) 2012 Cancer Research UK

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