Chronic widespread bodily pain is increased among individuals with history of fracture

findings from UK Biobank

Karen Walker-Bone, Nicholas C Harvey, Georgia Ntani, Tannaze Tinati, Gareth T Jones, Blair H Smith, Gary J Macfarlane, Cyrus Cooper

Research output: Contribution to journalArticle

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Abstract

UNLABELLED: In this cross-sectional analysis of the UK Biobank cohort, a history of fracture was associated with increased risk of current widespread chronic pain.

PURPOSE/INTRODUCTION: We aimed to test the hypothesis that a history of fracture is associated with reporting chronic widespread bodily pain (CWBP), using baseline data from the UK Biobank cohort, comprising 502,656 people aged 40-69 years.

METHODS: The case definition of current chronic widespread bodily pain was based on a response of 'yes' to the question 'do you have pain all over the body?' and 'yes' to 'and have you experienced pain all over the body for more than 3 months?' Multivariable Poisson regression with robust standard errors was used to test the relationship between fracture (occurring within 5 years prior to the baseline interview, and recorded by self-report) at the spine, hip, upper limb or lower limb and CWBP, adjusting for confounders.

RESULTS: Of 501,733 participants (mean age 56.5 years), 7130 individuals reported CWBP and 23,177 had a history of fracture affecting the upper limb, lower limb, spine and/or hip. Individuals with prior fracture were significantly more likely to report CWBP than those without. After adjustment for potential risk factors (age, gender, demographic, lifestyle and socioeconomic, and psychological), risk ratios were attenuated but remained statistically significant with a more than doubling of risk for CWBP with spine fractures in men (risk ratio (RR) 2.67, 95 % confidence interval (CI) 1.66-4.31; p < 0.001) and women (RR 2.13, 95 % CI 1.35-3.37, p = 0.001) and with hip fractures in women (RR 2.19, 95 % CI 1.33-3.59; p = 0.002).

CONCLUSIONS: In this cross-sectional analysis, previous fracture is associated with an increased likelihood of chronic widespread bodily pain, particularly with hip fractures in women, and spine fractures in both sexes. If replicated, these findings may help inform the identification of those most at risk of chronic widespread pain post-fracture, allowing preventative measures to be targeted.

Original languageEnglish
Article number1
JournalArchives of Osteoporosis
Volume11
Early online date17 Dec 2015
DOIs
Publication statusPublished - Dec 2016

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Chronic Pain
Spine
Odds Ratio
Hip Fractures
Confidence Intervals
Upper Extremity
Hip
Lower Extremity
Cross-Sectional Studies
Pain
Self Report
Life Style
Demography
Interviews
Psychology

Keywords

  • Epidemiology
  • Chronic widespread pain
  • Fracture
  • UK Biobank
  • Stressors

Cite this

Chronic widespread bodily pain is increased among individuals with history of fracture : findings from UK Biobank. / Walker-Bone, Karen; Harvey, Nicholas C; Ntani, Georgia; Tinati, Tannaze; Jones, Gareth T; Smith, Blair H; Macfarlane, Gary J; Cooper, Cyrus.

In: Archives of Osteoporosis, Vol. 11, 1, 12.2016.

Research output: Contribution to journalArticle

Walker-Bone, Karen ; Harvey, Nicholas C ; Ntani, Georgia ; Tinati, Tannaze ; Jones, Gareth T ; Smith, Blair H ; Macfarlane, Gary J ; Cooper, Cyrus. / Chronic widespread bodily pain is increased among individuals with history of fracture : findings from UK Biobank. In: Archives of Osteoporosis. 2016 ; Vol. 11.
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abstract = "UNLABELLED: In this cross-sectional analysis of the UK Biobank cohort, a history of fracture was associated with increased risk of current widespread chronic pain.PURPOSE/INTRODUCTION: We aimed to test the hypothesis that a history of fracture is associated with reporting chronic widespread bodily pain (CWBP), using baseline data from the UK Biobank cohort, comprising 502,656 people aged 40-69 years.METHODS: The case definition of current chronic widespread bodily pain was based on a response of 'yes' to the question 'do you have pain all over the body?' and 'yes' to 'and have you experienced pain all over the body for more than 3 months?' Multivariable Poisson regression with robust standard errors was used to test the relationship between fracture (occurring within 5 years prior to the baseline interview, and recorded by self-report) at the spine, hip, upper limb or lower limb and CWBP, adjusting for confounders.RESULTS: Of 501,733 participants (mean age 56.5 years), 7130 individuals reported CWBP and 23,177 had a history of fracture affecting the upper limb, lower limb, spine and/or hip. Individuals with prior fracture were significantly more likely to report CWBP than those without. After adjustment for potential risk factors (age, gender, demographic, lifestyle and socioeconomic, and psychological), risk ratios were attenuated but remained statistically significant with a more than doubling of risk for CWBP with spine fractures in men (risk ratio (RR) 2.67, 95 {\%} confidence interval (CI) 1.66-4.31; p < 0.001) and women (RR 2.13, 95 {\%} CI 1.35-3.37, p = 0.001) and with hip fractures in women (RR 2.19, 95 {\%} CI 1.33-3.59; p = 0.002).CONCLUSIONS: In this cross-sectional analysis, previous fracture is associated with an increased likelihood of chronic widespread bodily pain, particularly with hip fractures in women, and spine fractures in both sexes. If replicated, these findings may help inform the identification of those most at risk of chronic widespread pain post-fracture, allowing preventative measures to be targeted.",
keywords = "Epidemiology, Chronic widespread pain, Fracture, UK Biobank, Stressors",
author = "Karen Walker-Bone and Harvey, {Nicholas C} and Georgia Ntani and Tannaze Tinati and Jones, {Gareth T} and Smith, {Blair H} and Macfarlane, {Gary J} and Cyrus Cooper",
note = "Acknowledgments This work was supported by grants from the Medical Research Council, British Heart Foundation, Arthritis Research UK, National Osteoporosis Society, International Osteoporosis Foundation, NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford. This research has been conducted using the UK Biobank Resource. Compliance with ethical standards.",
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T1 - Chronic widespread bodily pain is increased among individuals with history of fracture

T2 - findings from UK Biobank

AU - Walker-Bone, Karen

AU - Harvey, Nicholas C

AU - Ntani, Georgia

AU - Tinati, Tannaze

AU - Jones, Gareth T

AU - Smith, Blair H

AU - Macfarlane, Gary J

AU - Cooper, Cyrus

N1 - Acknowledgments This work was supported by grants from the Medical Research Council, British Heart Foundation, Arthritis Research UK, National Osteoporosis Society, International Osteoporosis Foundation, NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford. This research has been conducted using the UK Biobank Resource. Compliance with ethical standards.

PY - 2016/12

Y1 - 2016/12

N2 - UNLABELLED: In this cross-sectional analysis of the UK Biobank cohort, a history of fracture was associated with increased risk of current widespread chronic pain.PURPOSE/INTRODUCTION: We aimed to test the hypothesis that a history of fracture is associated with reporting chronic widespread bodily pain (CWBP), using baseline data from the UK Biobank cohort, comprising 502,656 people aged 40-69 years.METHODS: The case definition of current chronic widespread bodily pain was based on a response of 'yes' to the question 'do you have pain all over the body?' and 'yes' to 'and have you experienced pain all over the body for more than 3 months?' Multivariable Poisson regression with robust standard errors was used to test the relationship between fracture (occurring within 5 years prior to the baseline interview, and recorded by self-report) at the spine, hip, upper limb or lower limb and CWBP, adjusting for confounders.RESULTS: Of 501,733 participants (mean age 56.5 years), 7130 individuals reported CWBP and 23,177 had a history of fracture affecting the upper limb, lower limb, spine and/or hip. Individuals with prior fracture were significantly more likely to report CWBP than those without. After adjustment for potential risk factors (age, gender, demographic, lifestyle and socioeconomic, and psychological), risk ratios were attenuated but remained statistically significant with a more than doubling of risk for CWBP with spine fractures in men (risk ratio (RR) 2.67, 95 % confidence interval (CI) 1.66-4.31; p < 0.001) and women (RR 2.13, 95 % CI 1.35-3.37, p = 0.001) and with hip fractures in women (RR 2.19, 95 % CI 1.33-3.59; p = 0.002).CONCLUSIONS: In this cross-sectional analysis, previous fracture is associated with an increased likelihood of chronic widespread bodily pain, particularly with hip fractures in women, and spine fractures in both sexes. If replicated, these findings may help inform the identification of those most at risk of chronic widespread pain post-fracture, allowing preventative measures to be targeted.

AB - UNLABELLED: In this cross-sectional analysis of the UK Biobank cohort, a history of fracture was associated with increased risk of current widespread chronic pain.PURPOSE/INTRODUCTION: We aimed to test the hypothesis that a history of fracture is associated with reporting chronic widespread bodily pain (CWBP), using baseline data from the UK Biobank cohort, comprising 502,656 people aged 40-69 years.METHODS: The case definition of current chronic widespread bodily pain was based on a response of 'yes' to the question 'do you have pain all over the body?' and 'yes' to 'and have you experienced pain all over the body for more than 3 months?' Multivariable Poisson regression with robust standard errors was used to test the relationship between fracture (occurring within 5 years prior to the baseline interview, and recorded by self-report) at the spine, hip, upper limb or lower limb and CWBP, adjusting for confounders.RESULTS: Of 501,733 participants (mean age 56.5 years), 7130 individuals reported CWBP and 23,177 had a history of fracture affecting the upper limb, lower limb, spine and/or hip. Individuals with prior fracture were significantly more likely to report CWBP than those without. After adjustment for potential risk factors (age, gender, demographic, lifestyle and socioeconomic, and psychological), risk ratios were attenuated but remained statistically significant with a more than doubling of risk for CWBP with spine fractures in men (risk ratio (RR) 2.67, 95 % confidence interval (CI) 1.66-4.31; p < 0.001) and women (RR 2.13, 95 % CI 1.35-3.37, p = 0.001) and with hip fractures in women (RR 2.19, 95 % CI 1.33-3.59; p = 0.002).CONCLUSIONS: In this cross-sectional analysis, previous fracture is associated with an increased likelihood of chronic widespread bodily pain, particularly with hip fractures in women, and spine fractures in both sexes. If replicated, these findings may help inform the identification of those most at risk of chronic widespread pain post-fracture, allowing preventative measures to be targeted.

KW - Epidemiology

KW - Chronic widespread pain

KW - Fracture

KW - UK Biobank

KW - Stressors

U2 - 10.1007/s11657-015-0252-1

DO - 10.1007/s11657-015-0252-1

M3 - Article

VL - 11

JO - Archives of Osteoporosis

JF - Archives of Osteoporosis

SN - 1862-3522

M1 - 1

ER -