Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer

R N Whistance, T Conroy, W Chie, A Costantini, O Sezer, M Koller, C D Johnson, S A Pilkington, J Arraras, E Ben-Josef, A M Pullyblank, P Fayers, J M Blazeby, European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group

Research output: Contribution to journalArticle

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Abstract

This international study aimed to test the measurement properties of the updated European Organisation for Research and Treatment of Cancer (EORTC) questionnaire module for colorectal cancer, the QLQ-CR29. The QLQ-CR29 was administered with the QLQ-C30, core questionnaire, to 351 patients from seven countries. Questionnaire scaling and reliability were established and clinical and psychometric validity examined. Patient acceptability and understanding were assessed with a debriefing questionnaire. Multi-trait scaling analyses and face validity refined the module to four scales assessing urinary frequency, faecal seepage, stool consistency and body image and single items assessing other common problems following treatment for colorectal cancer. Scales distinguished between clinically distinct groups of patients and did not correlate with QLQ-C30 scales, demonstrating construct validity. The QLQ-CR29 scores were reproducible over time in stable health. The EORTC QLQ-CR29 demonstrates sufficient validity and reliability to support its use to supplement the EORTC QLQ-C30 to assess patient-reported outcomes during treatment for colorectal cancer in clinical trials and other settings.
Original languageEnglish
Pages (from-to)3017-3026
Number of pages10
JournalEuropean Journal of Cancer
Volume45
Issue number17
Early online date16 Sep 2009
DOIs
Publication statusPublished - Nov 2009

Fingerprint

Psychometrics
Colorectal Neoplasms
Quality of Life
Organizations
Research
Reproducibility of Results
Neoplasms
Body Image
Therapeutics
Clinical Trials
Surveys and Questionnaires
Health

Keywords

  • adenocarcinoma
  • aged
  • colectomy
  • colorectal neoplasms
  • combined modality therapy
  • defecation
  • epidemiologic methods
  • female
  • health status indicators
  • humans
  • international cooperation
  • male
  • middle aged
  • psychometrics
  • quality of life
  • questionnaires
  • surgical Stomas
  • urination
  • questionnaire
  • validation
  • colorectal cancer
  • EORTC

Cite this

Whistance, R. N., Conroy, T., Chie, W., Costantini, A., Sezer, O., Koller, M., ... European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (2009). Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer. European Journal of Cancer, 45(17), 3017-3026. https://doi.org/10.1016/j.ejca.2009.08.014

Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer. / Whistance, R N; Conroy, T; Chie, W; Costantini, A; Sezer, O; Koller, M; Johnson, C D; Pilkington, S A; Arraras, J; Ben-Josef, E; Pullyblank, A M; Fayers, P; Blazeby, J M; European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group.

In: European Journal of Cancer, Vol. 45, No. 17, 11.2009, p. 3017-3026.

Research output: Contribution to journalArticle

Whistance, RN, Conroy, T, Chie, W, Costantini, A, Sezer, O, Koller, M, Johnson, CD, Pilkington, SA, Arraras, J, Ben-Josef, E, Pullyblank, AM, Fayers, P, Blazeby, JM & European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group 2009, 'Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer' European Journal of Cancer, vol. 45, no. 17, pp. 3017-3026. https://doi.org/10.1016/j.ejca.2009.08.014
Whistance, R N ; Conroy, T ; Chie, W ; Costantini, A ; Sezer, O ; Koller, M ; Johnson, C D ; Pilkington, S A ; Arraras, J ; Ben-Josef, E ; Pullyblank, A M ; Fayers, P ; Blazeby, J M ; European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group. / Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer. In: European Journal of Cancer. 2009 ; Vol. 45, No. 17. pp. 3017-3026.
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abstract = "This international study aimed to test the measurement properties of the updated European Organisation for Research and Treatment of Cancer (EORTC) questionnaire module for colorectal cancer, the QLQ-CR29. The QLQ-CR29 was administered with the QLQ-C30, core questionnaire, to 351 patients from seven countries. Questionnaire scaling and reliability were established and clinical and psychometric validity examined. Patient acceptability and understanding were assessed with a debriefing questionnaire. Multi-trait scaling analyses and face validity refined the module to four scales assessing urinary frequency, faecal seepage, stool consistency and body image and single items assessing other common problems following treatment for colorectal cancer. Scales distinguished between clinically distinct groups of patients and did not correlate with QLQ-C30 scales, demonstrating construct validity. The QLQ-CR29 scores were reproducible over time in stable health. The EORTC QLQ-CR29 demonstrates sufficient validity and reliability to support its use to supplement the EORTC QLQ-C30 to assess patient-reported outcomes during treatment for colorectal cancer in clinical trials and other settings.",
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note = "Acknowledgements This study was supported by a grant from the EORTC Quality of Life Group. In Berlin the study was supported by a research grant from Deutsche Krebshilfe, Bonn, Germany. We acknowledge Francesca New, in Southampton and Isabelle Leonard in Nancy, who helped to collect the quality of life data. We thank Mr. Michael Thomas, Mr. Paul Sylvester, Mr. Robert Longman and Mr. Paul Durdey from University Hospitals Bristol NHS Foundation Trust and Mr. Tony Dixon from North Bristol Trust for allowing us to study the patients under their care. We also acknowledge Professor Mirjam Sprangers, Amsterdam Medical Centre, who allowed us to use and update the EORTC QLQ-CR38. Thanks to Dr John Ramage and Mrs Barbara Kingman, who assisted data collection in Basingstoke, UK and to Dr Sameer Gujral who assisted the set up of this study in Bristol.",
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