Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer

R N Whistance; T Conroy; W Chie; A Costantini; O Sezer; M Koller; C D Johnson; S A Pilkington; J Arraras; E Ben-Josef; A M Pullyblank; P Fayers; J M Blazeby; European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group

doi:10.1016/j.ejca.2009.08.014

Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer

R N Whistance, T Conroy, W Chie, A Costantini, O Sezer, M Koller, C D Johnson, S A Pilkington, J Arraras, E Ben-Josef, A M Pullyblank, P Fayers, J M Blazeby, European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group

Applied Health Sciences

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Abstract

This international study aimed to test the measurement properties of the updated European Organisation for Research and Treatment of Cancer (EORTC) questionnaire module for colorectal cancer, the QLQ-CR29. The QLQ-CR29 was administered with the QLQ-C30, core questionnaire, to 351 patients from seven countries. Questionnaire scaling and reliability were established and clinical and psychometric validity examined. Patient acceptability and understanding were assessed with a debriefing questionnaire. Multi-trait scaling analyses and face validity refined the module to four scales assessing urinary frequency, faecal seepage, stool consistency and body image and single items assessing other common problems following treatment for colorectal cancer. Scales distinguished between clinically distinct groups of patients and did not correlate with QLQ-C30 scales, demonstrating construct validity. The QLQ-CR29 scores were reproducible over time in stable health. The EORTC QLQ-CR29 demonstrates sufficient validity and reliability to support its use to supplement the EORTC QLQ-C30 to assess patient-reported outcomes during treatment for colorectal cancer in clinical trials and other settings.

Original language	English
Pages (from-to)	3017-3026
Number of pages	10
Journal	European Journal of Cancer
Volume	45
Issue number	17
Early online date	16 Sept 2009
DOIs	https://doi.org/10.1016/j.ejca.2009.08.014
Publication status	Published - Nov 2009

Bibliographical note

Acknowledgements
This study was supported by a grant from the EORTC Quality of Life Group. In Berlin the study was supported by a research grant from Deutsche Krebshilfe, Bonn, Germany. We acknowledge Francesca New, in Southampton and Isabelle Leonard in Nancy, who helped to collect the quality of life data. We thank Mr. Michael Thomas, Mr. Paul Sylvester, Mr. Robert Longman and Mr. Paul Durdey from University Hospitals Bristol NHS Foundation Trust and Mr. Tony Dixon from North Bristol Trust for allowing us to study the patients under their care. We also acknowledge Professor Mirjam Sprangers, Amsterdam Medical Centre, who allowed us to use and update the EORTC QLQ-CR38. Thanks to Dr John Ramage and Mrs Barbara Kingman, who assisted data collection in Basingstoke, UK and to Dr Sameer Gujral who assisted the set up of this study in Bristol.

Keywords

adenocarcinoma
aged
colectomy
colorectal neoplasms
combined modality therapy
defecation
epidemiologic methods
female
health status indicators
humans
international cooperation
male
middle aged
psychometrics
quality of life
questionnaires
surgical Stomas
urination
questionnaire
validation
colorectal cancer
EORTC

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Whistance, R. N., Conroy, T., Chie, W., Costantini, A., Sezer, O., Koller, M., Johnson, C. D., Pilkington, S. A., Arraras, J., Ben-Josef, E., Pullyblank, A. M., Fayers, P., Blazeby, J. M., & European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (2009). Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer. European Journal of Cancer, 45(17), 3017-3026. https://doi.org/10.1016/j.ejca.2009.08.014

Whistance, RN, Conroy, T, Chie, W, Costantini, A, Sezer, O, Koller, M, Johnson, CD, Pilkington, SA, Arraras, J, Ben-Josef, E, Pullyblank, AM, Fayers, P, Blazeby, JM & European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group 2009, 'Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer', European Journal of Cancer, vol. 45, no. 17, pp. 3017-3026. https://doi.org/10.1016/j.ejca.2009.08.014

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abstract = "This international study aimed to test the measurement properties of the updated European Organisation for Research and Treatment of Cancer (EORTC) questionnaire module for colorectal cancer, the QLQ-CR29. The QLQ-CR29 was administered with the QLQ-C30, core questionnaire, to 351 patients from seven countries. Questionnaire scaling and reliability were established and clinical and psychometric validity examined. Patient acceptability and understanding were assessed with a debriefing questionnaire. Multi-trait scaling analyses and face validity refined the module to four scales assessing urinary frequency, faecal seepage, stool consistency and body image and single items assessing other common problems following treatment for colorectal cancer. Scales distinguished between clinically distinct groups of patients and did not correlate with QLQ-C30 scales, demonstrating construct validity. The QLQ-CR29 scores were reproducible over time in stable health. The EORTC QLQ-CR29 demonstrates sufficient validity and reliability to support its use to supplement the EORTC QLQ-C30 to assess patient-reported outcomes during treatment for colorectal cancer in clinical trials and other settings.",

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note = "Acknowledgements This study was supported by a grant from the EORTC Quality of Life Group. In Berlin the study was supported by a research grant from Deutsche Krebshilfe, Bonn, Germany. We acknowledge Francesca New, in Southampton and Isabelle Leonard in Nancy, who helped to collect the quality of life data. We thank Mr. Michael Thomas, Mr. Paul Sylvester, Mr. Robert Longman and Mr. Paul Durdey from University Hospitals Bristol NHS Foundation Trust and Mr. Tony Dixon from North Bristol Trust for allowing us to study the patients under their care. We also acknowledge Professor Mirjam Sprangers, Amsterdam Medical Centre, who allowed us to use and update the EORTC QLQ-CR38. Thanks to Dr John Ramage and Mrs Barbara Kingman, who assisted data collection in Basingstoke, UK and to Dr Sameer Gujral who assisted the set up of this study in Bristol.",

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AU - Costantini, A

AU - Sezer, O

AU - Koller, M

AU - Johnson, C D

AU - Pilkington, S A

AU - Arraras, J

AU - Ben-Josef, E

AU - Pullyblank, A M

AU - Fayers, P

AU - Blazeby, J M

AU - European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group

N1 - Acknowledgements This study was supported by a grant from the EORTC Quality of Life Group. In Berlin the study was supported by a research grant from Deutsche Krebshilfe, Bonn, Germany. We acknowledge Francesca New, in Southampton and Isabelle Leonard in Nancy, who helped to collect the quality of life data. We thank Mr. Michael Thomas, Mr. Paul Sylvester, Mr. Robert Longman and Mr. Paul Durdey from University Hospitals Bristol NHS Foundation Trust and Mr. Tony Dixon from North Bristol Trust for allowing us to study the patients under their care. We also acknowledge Professor Mirjam Sprangers, Amsterdam Medical Centre, who allowed us to use and update the EORTC QLQ-CR38. Thanks to Dr John Ramage and Mrs Barbara Kingman, who assisted data collection in Basingstoke, UK and to Dr Sameer Gujral who assisted the set up of this study in Bristol.

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N2 - This international study aimed to test the measurement properties of the updated European Organisation for Research and Treatment of Cancer (EORTC) questionnaire module for colorectal cancer, the QLQ-CR29. The QLQ-CR29 was administered with the QLQ-C30, core questionnaire, to 351 patients from seven countries. Questionnaire scaling and reliability were established and clinical and psychometric validity examined. Patient acceptability and understanding were assessed with a debriefing questionnaire. Multi-trait scaling analyses and face validity refined the module to four scales assessing urinary frequency, faecal seepage, stool consistency and body image and single items assessing other common problems following treatment for colorectal cancer. Scales distinguished between clinically distinct groups of patients and did not correlate with QLQ-C30 scales, demonstrating construct validity. The QLQ-CR29 scores were reproducible over time in stable health. The EORTC QLQ-CR29 demonstrates sufficient validity and reliability to support its use to supplement the EORTC QLQ-C30 to assess patient-reported outcomes during treatment for colorectal cancer in clinical trials and other settings.

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KW - aged

KW - colectomy

KW - colorectal neoplasms

KW - combined modality therapy

KW - defecation

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KW - female

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KW - humans

KW - international cooperation

KW - male

KW - middle aged

KW - psychometrics

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KW - questionnaires

KW - surgical Stomas

KW - urination

KW - questionnaire

KW - validation

KW - colorectal cancer

KW - EORTC

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DO - 10.1016/j.ejca.2009.08.014

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SN - 0959-8049

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JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 17

ER -

Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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