Clionasterol, a triterpenoid from the Kenyan marine green macroalga halimeda macroloba

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Abstract

The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.
Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalWestern Indian Ocean Journal of Marine Science
Volume2
Issue number2
DOIs
Publication statusPublished - 2003

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Stereochemistry
Hexanes
Algae
Metabolites
Mass spectrometry
Assays
Carbon
Nuclear magnetic resonance
Experiments
brine
gamma-sitosterol
thiazolyl blue

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title = "Clionasterol, a triterpenoid from the Kenyan marine green macroalga halimeda macroloba",
abstract = "The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20{\%} EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.",
author = "Thomas Dzeha and Marcel Jaspars and Jioji Tabudravu",
year = "2003",
doi = "10.4314/wiojms.v2i2.28436",
language = "English",
volume = "2",
pages = "157--161",
journal = "Western Indian Ocean Journal of Marine Science",
issn = "0856-860X",
number = "2",

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T1 - Clionasterol, a triterpenoid from the Kenyan marine green macroalga halimeda macroloba

AU - Dzeha, Thomas

AU - Jaspars, Marcel

AU - Tabudravu, Jioji

PY - 2003

Y1 - 2003

N2 - The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.

AB - The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.

U2 - 10.4314/wiojms.v2i2.28436

DO - 10.4314/wiojms.v2i2.28436

M3 - Article

VL - 2

SP - 157

EP - 161

JO - Western Indian Ocean Journal of Marine Science

JF - Western Indian Ocean Journal of Marine Science

SN - 0856-860X

IS - 2

ER -