Clionasterol, a triterpenoid from the Kenyan marine green macroalga halimeda macroloba

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Abstract

The triterpenoid clionasterol (1), a 29 carbon structure compound was isolated from the less polar extract (20% EtOAc in hexanes) of the green alga Halimeda macroloba collected at Shimoni near Mombasa, Kenya. The structure and relative stereochemistry of this compound was elucidated by spectroscopic data, mainly NMR and mass spectrometry. This metabolite was inactive against DLD-1 cells on the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Further experiments on mosquito larvae and brine shrimp lethality confirmed this result.
Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalWestern Indian Ocean Journal of Marine Science
Volume2
Issue number2
DOIs
Publication statusPublished - 2003

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