Clonality structure in Candida dubliniensis

C. Badoc, T. De Meeus, Frank Christopher Odds, M. Mallie, J. M. Bastide, S. Bertout

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    Abstract

    Multilocus enzyme electrophoresis was performed on 76 European strains of Candida dubliniensis. Ten of the 20 enzyme-encoding loci were polymorphic, giving rise to 10 electrophoretic types within the sample studied. Investigation of the population genetics of a subset of 36 strains from HIV-infected patients in London showed the existence of strong heterozygote deficits and excesses associated with significant linkage disequilibria between pairs of loci. These findings, together with the predominance of multilocus genotypes, strongly suggest that C dubliniensis is mainly (if not totally) clonal. Analysis of genotypes of a larger number of strains should confirm this conclusion and improve our understanding of the epidemiology of this pathogen. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)249-254
    Number of pages5
    JournalFEMS Microbiology Letters
    Volume209
    Issue number2
    DOIs
    Publication statusPublished - 2002

    Keywords

    • molecular typing
    • population genetics
    • reproduction mode
    • POPULATION-STRUCTURE
    • ALBICANS
    • STRAINS
    • RECOMBINATION
    • DEFICIENCY

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