Clonality structure in Candida dubliniensis

C. Badoc; T. De Meeus; Frank Christopher Odds; M. Mallie; J. M. Bastide; S. Bertout

doi:10.1111/j.1574-6968.2002.tb11139.x

Clonality structure in Candida dubliniensis

C. Badoc, T. De Meeus, Frank Christopher Odds, M. Mallie, J. M. Bastide, S. Bertout

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Multilocus enzyme electrophoresis was performed on 76 European strains of Candida dubliniensis. Ten of the 20 enzyme-encoding loci were polymorphic, giving rise to 10 electrophoretic types within the sample studied. Investigation of the population genetics of a subset of 36 strains from HIV-infected patients in London showed the existence of strong heterozygote deficits and excesses associated with significant linkage disequilibria between pairs of loci. These findings, together with the predominance of multilocus genotypes, strongly suggest that C dubliniensis is mainly (if not totally) clonal. Analysis of genotypes of a larger number of strains should confirm this conclusion and improve our understanding of the epidemiology of this pathogen. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	249-254
Number of pages	5
Journal	FEMS Microbiology Letters
Volume	209
Issue number	2
DOIs	https://doi.org/10.1111/j.1574-6968.2002.tb11139.x
Publication status	Published - 2002

Keywords

molecular typing
population genetics
reproduction mode
POPULATION-STRUCTURE
ALBICANS
STRAINS
RECOMBINATION
DEFICIENCY

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1574-6968.2002.tb11139.x

Cite this

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title = "Clonality structure in Candida dubliniensis",

abstract = "Multilocus enzyme electrophoresis was performed on 76 European strains of Candida dubliniensis. Ten of the 20 enzyme-encoding loci were polymorphic, giving rise to 10 electrophoretic types within the sample studied. Investigation of the population genetics of a subset of 36 strains from HIV-infected patients in London showed the existence of strong heterozygote deficits and excesses associated with significant linkage disequilibria between pairs of loci. These findings, together with the predominance of multilocus genotypes, strongly suggest that C dubliniensis is mainly (if not totally) clonal. Analysis of genotypes of a larger number of strains should confirm this conclusion and improve our understanding of the epidemiology of this pathogen. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.",

keywords = "molecular typing, population genetics, reproduction mode, POPULATION-STRUCTURE, ALBICANS, STRAINS, RECOMBINATION, DEFICIENCY",

author = "C. Badoc and {De Meeus}, T. and Odds, {Frank Christopher} and M. Mallie and Bastide, {J. M.} and S. Bertout",

year = "2002",

doi = "10.1111/j.1574-6968.2002.tb11139.x",

language = "English",

volume = "209",

pages = "249--254",

journal = "FEMS Microbiology Letters",

issn = "0378-1097",

publisher = "Oxford University Press",

number = "2",

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TY - JOUR

T1 - Clonality structure in Candida dubliniensis

AU - Badoc, C.

AU - De Meeus, T.

AU - Odds, Frank Christopher

AU - Mallie, M.

AU - Bastide, J. M.

AU - Bertout, S.

PY - 2002

Y1 - 2002

N2 - Multilocus enzyme electrophoresis was performed on 76 European strains of Candida dubliniensis. Ten of the 20 enzyme-encoding loci were polymorphic, giving rise to 10 electrophoretic types within the sample studied. Investigation of the population genetics of a subset of 36 strains from HIV-infected patients in London showed the existence of strong heterozygote deficits and excesses associated with significant linkage disequilibria between pairs of loci. These findings, together with the predominance of multilocus genotypes, strongly suggest that C dubliniensis is mainly (if not totally) clonal. Analysis of genotypes of a larger number of strains should confirm this conclusion and improve our understanding of the epidemiology of this pathogen. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

AB - Multilocus enzyme electrophoresis was performed on 76 European strains of Candida dubliniensis. Ten of the 20 enzyme-encoding loci were polymorphic, giving rise to 10 electrophoretic types within the sample studied. Investigation of the population genetics of a subset of 36 strains from HIV-infected patients in London showed the existence of strong heterozygote deficits and excesses associated with significant linkage disequilibria between pairs of loci. These findings, together with the predominance of multilocus genotypes, strongly suggest that C dubliniensis is mainly (if not totally) clonal. Analysis of genotypes of a larger number of strains should confirm this conclusion and improve our understanding of the epidemiology of this pathogen. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

KW - molecular typing

KW - population genetics

KW - reproduction mode

KW - POPULATION-STRUCTURE

KW - ALBICANS

KW - STRAINS

KW - RECOMBINATION

KW - DEFICIENCY

U2 - 10.1111/j.1574-6968.2002.tb11139.x

DO - 10.1111/j.1574-6968.2002.tb11139.x

M3 - Article

VL - 209

SP - 249

EP - 254

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

SN - 0378-1097

IS - 2

ER -

Clonality structure in Candida dubliniensis

Abstract

Keywords

UN SDGs

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