Cloning and bioactivity of fish cytokines and their relevance to disease resistance

Christopher John Secombes

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7 Citations (Scopus)

Abstract

Cytokines are the signalling molecules within the immune system. Typically they have a low constitutive expression but on stimulation by infection or an inflammatory insult they are rapidly turned on. They can both initiate and regulate inflammatory reactions and several are important accessory factors required for optimal stimulation of the specific defences. Within fish several of the key cytokine genes have been cloned in recent years, including molecules such as interleukin-1beta (IL-1beta)(Zou et al., 1999; Scapigliati et al., 2001), tumor necrosis factor a (TNFa)(Hirono et al., 2000; Laing et al., 2001), transforming growth factor-beta (TGF-beta)(Hardie et al., 1998; Laing et al., 2000), and several chemokines (see below for definition) including IL-8 (Laing et al., in press) and gamma interferon inducible protein (gammaIP)(Laing & Secombes, 2001) amongst others (Dixon et al., 1998; Kono Sakai, 2001).

Original languageEnglish
Pages (from-to)110-116
Number of pages6
JournalBulletin of the European Association of Fish Pathologists
Volume22
Publication statusPublished - 2002

Keywords

  • TROUT ONCORHYNCHUS-MYKISS
  • CELLULAR IMMUNE-RESPONSES
  • GROWTH-FACTOR-BETA
  • MOLECULAR-CLONING
  • EXPRESSION ANALYSIS
  • CPG OLIGODEOXYNUCLEOTIDES
  • RECOMBINANT IL-1-BETA
  • JAPANESE FLOUNDER
  • DNA VACCINATION
  • IFN-GAMMA

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