Cloning of the Atlantic salmon (Salmo salar) IL-1 receptor associated protein

C Stansberg, S Subramaniam, B Collet, C J Secombes, C Cunningham

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In mammals, the pro-inflammatory cytokine interleukin-1 signals through a receptor complex containing a type I interleukin-1 receptor (IL-1RI) and a receptor associated protein (IL-1RAcP). Previously, we have described a cDNA from Atlantic salmon encoding a molecule with homology to the mammalian IL-RI. This molecule was named IL-1 receptor like protein (IL-1RLP) in the absence of functional data to support its proposed role as the salmon IL-1RI. Here, we describe the cloning and characterisation. of a cDNA encoding salmon IL-1RAcP. Like other members of the IL-1R family, the salmon IL-1RAcP encodes three extracellular immunoglobulin-like domains and a cytoplasmic Toll/Interleukin-1 receptor (TIR) domain involved in signalling. Specific binding of salmon IL-1RAcP to IL-1RLP was shown by co-immunoprecipitation studies. (c) 2005 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)53-65
Number of pages13
JournalFish & Shellfish Immunology
Volume19
DOIs
Publication statusPublished - 2005

Keywords

  • Salmo salar
  • IL-1R family
  • TIR family
  • IL-1
  • IL-1RLP
  • IL-1RAcP
  • TROUT ONCORHYNCHUS-MYKISS
  • INTERLEUKIN-1 RECEPTOR
  • ACCESSORY PROTEIN
  • IRAK
  • COMPLEX
  • FAMILY
  • IDENTIFICATION
  • EXPRESSION
  • PATHWAY
  • MEMBER

Cite this

Cloning of the Atlantic salmon (Salmo salar) IL-1 receptor associated protein. / Stansberg, C ; Subramaniam, S ; Collet, B ; Secombes, C J ; Cunningham, C .

In: Fish & Shellfish Immunology, Vol. 19, 2005, p. 53-65.

Research output: Contribution to journalArticle

Stansberg, C ; Subramaniam, S ; Collet, B ; Secombes, C J ; Cunningham, C . / Cloning of the Atlantic salmon (Salmo salar) IL-1 receptor associated protein. In: Fish & Shellfish Immunology. 2005 ; Vol. 19. pp. 53-65.
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AU - Subramaniam, S

AU - Collet, B

AU - Secombes, C J

AU - Cunningham, C

PY - 2005

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N2 - In mammals, the pro-inflammatory cytokine interleukin-1 signals through a receptor complex containing a type I interleukin-1 receptor (IL-1RI) and a receptor associated protein (IL-1RAcP). Previously, we have described a cDNA from Atlantic salmon encoding a molecule with homology to the mammalian IL-RI. This molecule was named IL-1 receptor like protein (IL-1RLP) in the absence of functional data to support its proposed role as the salmon IL-1RI. Here, we describe the cloning and characterisation. of a cDNA encoding salmon IL-1RAcP. Like other members of the IL-1R family, the salmon IL-1RAcP encodes three extracellular immunoglobulin-like domains and a cytoplasmic Toll/Interleukin-1 receptor (TIR) domain involved in signalling. Specific binding of salmon IL-1RAcP to IL-1RLP was shown by co-immunoprecipitation studies. (c) 2005 Elsevier Ltd. All rights reserved.

AB - In mammals, the pro-inflammatory cytokine interleukin-1 signals through a receptor complex containing a type I interleukin-1 receptor (IL-1RI) and a receptor associated protein (IL-1RAcP). Previously, we have described a cDNA from Atlantic salmon encoding a molecule with homology to the mammalian IL-RI. This molecule was named IL-1 receptor like protein (IL-1RLP) in the absence of functional data to support its proposed role as the salmon IL-1RI. Here, we describe the cloning and characterisation. of a cDNA encoding salmon IL-1RAcP. Like other members of the IL-1R family, the salmon IL-1RAcP encodes three extracellular immunoglobulin-like domains and a cytoplasmic Toll/Interleukin-1 receptor (TIR) domain involved in signalling. Specific binding of salmon IL-1RAcP to IL-1RLP was shown by co-immunoprecipitation studies. (c) 2005 Elsevier Ltd. All rights reserved.

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KW - TIR family

KW - IL-1

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KW - IL-1RAcP

KW - TROUT ONCORHYNCHUS-MYKISS

KW - INTERLEUKIN-1 RECEPTOR

KW - ACCESSORY PROTEIN

KW - IRAK

KW - COMPLEX

KW - FAMILY

KW - IDENTIFICATION

KW - EXPRESSION

KW - PATHWAY

KW - MEMBER

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JO - Fish & Shellfish Immunology

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SN - 1050-4648

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