Cluster trials in implementation research: estimation of intracluster correlation coefficients and sample size

Marion Kay Campbell, Jill Ann Mollison

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

The cluster randomized trial with a concurrent economic evaluation is considered the gold standard evaluative design for the conduct of implementation research evaluating different strategies to promote the transfer of research findings into clinical practice. This has implications for the planning of such studies, as information is needed on the effects of clustering on both effectiveness and efficiency outcomes. This paper describes the design considerations specific to implementation research studies, focusing particularly on the estimation of sample size requirements and on the need for reliable information on intracluster correlation coefficients for both effectiveness and efficiency outcomes. Copyright (C) 2001 John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)391-399
Number of pages8
JournalStatistics in Medicine
Volume20
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • INTRACLASS CORRELATION-COEFFICIENT
  • RANDOMIZED CONTROLLED TRIALS
  • COMMUNITY INTERVENTION
  • MYOCARDIAL-INFARCTION
  • SMOKING PREVENTION
  • CLINICAL-TRIALS
  • DESIGN
  • POWER
  • REQUIREMENTS
  • ECONOMICS

Impacts

Aberdeen research prompts change in dental policy benefiting thousands of Scottish children

Craig Ramsay (Coordinator), Jeremy M Grimshaw (Coordinator), Graeme MacLennan (Coordinator), Jan Clarkson (Coordinator), Nigel B. Pitts (Coordinator), Ruth Thomas (Coordinator), Elizabeth A Shirran (Coordinator), Marion Campbell (Coordinator) & Jill Ann Mollison (Coordinator)

Impact

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