CMIP and ATP2C2 modulate phonological short-term memory in language impairment

Dianne F. Newbury, Laura Winchester, Laura Addis, Silvia Paracchini, Lyn-Louise Buckingham, Ann Clark, Wendy Cohen, Hilary Cowie, Katharina Dworzynski, Andrea Everitt, Ian M. Goodyer, Elizabeth Hennessy, A. D. Kindley, Laura L. Miller, Jamal Nasir, Anne O'Hare, Duncan J. Shaw, Zoe Simkin, Emily Simonoff, Vicky SlonimsJocelynne Watson, Jiannis Ragoussis, Simon E. Fisher, Jonathon R. Seckl, Peter J. Helms, Patrick F. Bolton, Andrew Pickles, Gina Conti-Ramsden, Gillian Baird, Dorothy V. M. Bishop, Anthony P. Monaco

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111 Citations (Scopus)

Abstract

Specific language impairment (SLI) is a common developmental disorder characterized by difficulties in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors. We performed a high-density screen of SLI1, a region of chromosome 16q that shows highly significant and consistent linkage to nonword repetition, a measure of phonological short-term memory that is commonly impaired in SLI. Using two independent language-impaired samples, one family-based (211 families) and another selected from a population cohort on the basis of extreme language measures (490 cases), we detected association to two genes in the SLI 1 region: that encoding c-maf-inducing protein (CMIP, minP = 5.5 x 10(-7) at rs6564903) and that encoding calcium-transporting ATPase, type2C, member2 (ATP2C2, minP = 2.0 x 10(-5) at rs11860694). Regression modeling indicated that each of these loci exerts an independent effect upon nonword repetition ability. Despite the consistent findings in language-impaired samples, investigation in a large unselected cohort (n = 3612) did not detect association. We therefore propose that variants in CMIP and ATP2C2 act to modulate phonological short-term memory primarily in the context of language impairment. As such, this investigation supports the hypothesis that some causes of language impairment are distinct from factors that influence normal language variation. This work therefore implicates CMIP and ATP2C2 in the etiology of SLI and provides molecular evidence for the importance of phonological short-term memory in language acquisition.

Original languageEnglish
Pages (from-to)264-272
Number of pages9
JournalAmerican Journal of Human Genetics
Volume85
Issue number2
DOIs
Publication statusPublished - 14 Aug 2009

Keywords

  • working-memory
  • TC-MIP
  • children
  • speech
  • association
  • disorders
  • calcium
  • linkage
  • genome
  • literacy

Cite this

Newbury, D. F., Winchester, L., Addis, L., Paracchini, S., Buckingham, L-L., Clark, A., Cohen, W., Cowie, H., Dworzynski, K., Everitt, A., Goodyer, I. M., Hennessy, E., Kindley, A. D., Miller, L. L., Nasir, J., O'Hare, A., Shaw, D. J., Simkin, Z., Simonoff, E., ... Monaco, A. P. (2009). CMIP and ATP2C2 modulate phonological short-term memory in language impairment. American Journal of Human Genetics, 85(2), 264-272. https://doi.org/10.1016/j.ajhg.2009.07.004