Abstract
The endometrium displays characteristic cyclical changes involving proliferation and differentiation, The differentiation that takes place requires major tissue remodelling involving the matrix metalloproteinase (MMP) family as key enzymes in this process. Mast cells, containing the tryptase and chymase enzymes that are capable of stimulating the MMP cascade, have been identified in the endometrium, but their role is still unclear. In this study, we observed that the majority of mast cells in the uterus reside in the myometrium and that they co-express mast cell tryptase and MMP-1 in the same intracellular granules, In endometrium exposed to synthetic progestogen via an intrauterine levonorgestrel system a significant increase in mast cells numbers was observed in women experiencing breakthrough bleeding compared to those in women with no reported bleeding. We conclude that mast cells contain MMP-1 and we postulate a potential role for mast cells in breakthrough bleeding.
Original language | English |
---|---|
Pages (from-to) | 559-565 |
Number of pages | 6 |
Journal | Molecular Human Reproduction |
Volume | 7 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- endometrium
- levonorgestrel-IUS mast cells
- matrix metalloproteinase
- myometrium
- uterus
- HUMAN ENDOMETRIUM
- TISSUE INHIBITORS
- MENSTRUAL-CYCLE
- INTRAUTERINE LEVONORGESTREL
- PROGESTERONE WITHDRAWAL
- INTERSTITIAL CYSTITIS
- SMOOTH-MUSCLE
- GELATINASE-B
- EXPRESSION
- DECIDUALIZATION
Cite this
Co-localisation of matrix metalloproteinasae-1 and mast cell tryptase in human uterus. / Milne, S. A.; Rakhyoot, A.; Drudy, T. A.; Brechin, Susan; Riley, S. C.; Critchely, H. O. D.
In: Molecular Human Reproduction, Vol. 7, No. 6, 2001, p. 559-565.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Co-localisation of matrix metalloproteinasae-1 and mast cell tryptase in human uterus
AU - Milne, S. A.
AU - Rakhyoot, A.
AU - Drudy, T. A.
AU - Brechin, Susan
AU - Riley, S. C.
AU - Critchely, H. O. D.
PY - 2001
Y1 - 2001
N2 - The endometrium displays characteristic cyclical changes involving proliferation and differentiation, The differentiation that takes place requires major tissue remodelling involving the matrix metalloproteinase (MMP) family as key enzymes in this process. Mast cells, containing the tryptase and chymase enzymes that are capable of stimulating the MMP cascade, have been identified in the endometrium, but their role is still unclear. In this study, we observed that the majority of mast cells in the uterus reside in the myometrium and that they co-express mast cell tryptase and MMP-1 in the same intracellular granules, In endometrium exposed to synthetic progestogen via an intrauterine levonorgestrel system a significant increase in mast cells numbers was observed in women experiencing breakthrough bleeding compared to those in women with no reported bleeding. We conclude that mast cells contain MMP-1 and we postulate a potential role for mast cells in breakthrough bleeding.
AB - The endometrium displays characteristic cyclical changes involving proliferation and differentiation, The differentiation that takes place requires major tissue remodelling involving the matrix metalloproteinase (MMP) family as key enzymes in this process. Mast cells, containing the tryptase and chymase enzymes that are capable of stimulating the MMP cascade, have been identified in the endometrium, but their role is still unclear. In this study, we observed that the majority of mast cells in the uterus reside in the myometrium and that they co-express mast cell tryptase and MMP-1 in the same intracellular granules, In endometrium exposed to synthetic progestogen via an intrauterine levonorgestrel system a significant increase in mast cells numbers was observed in women experiencing breakthrough bleeding compared to those in women with no reported bleeding. We conclude that mast cells contain MMP-1 and we postulate a potential role for mast cells in breakthrough bleeding.
KW - endometrium
KW - levonorgestrel-IUS mast cells
KW - matrix metalloproteinase
KW - myometrium
KW - uterus
KW - HUMAN ENDOMETRIUM
KW - TISSUE INHIBITORS
KW - MENSTRUAL-CYCLE
KW - INTRAUTERINE LEVONORGESTREL
KW - PROGESTERONE WITHDRAWAL
KW - INTERSTITIAL CYSTITIS
KW - SMOOTH-MUSCLE
KW - GELATINASE-B
KW - EXPRESSION
KW - DECIDUALIZATION
U2 - 10.1093/molehr/7.6.559
DO - 10.1093/molehr/7.6.559
M3 - Article
VL - 7
SP - 559
EP - 565
JO - Molecular Human Reproduction
JF - Molecular Human Reproduction
SN - 1360-9947
IS - 6
ER -