Cognitive aging, childhood intelligence, and the use of food supplements: Possible involvement of n-3 fatty acids

Lawrence Jeffrey Whalley, Helen Catherine Fox, K. J. Wahle, J. M. Starr, I. J. Deary

    Research output: Contribution to journalArticle

    79 Citations (Scopus)

    Abstract

    Background: Food supplement use is widely promoted, but little is known about the cognitive effects of food supplements.

    Objective: We examined the effects of food supplement use on cognitive aging.

    Design: This was an observational study of subjects born in 1936 whose mental ability was tested in 1947 and who were followed up in 2000-2001, at which time cognition, diet, food supplement use, and risk factors for vascular disease were assessed. In a nested case-control study, fish-oil users were matched with nonusers, and cognitive function was related to erythrocyte n-3 fatty acid composition.

    Results: Childhood intelligence quotient (IQ) did not differ significantly by category of food supplement use (ie, none, fish oil, vitamins, and other). At the age of 64 y, cognitive function was higher in food supplement users than in nonusers before adjustment for childhood IQ. After adjustment for childhood IQ, digit symbol (mental speed) test scores were higher in food supplement users. Fish-oil supplement users consumed more vitamin C and vegetable and cereal fiber than did non-supplement-users. In a nested case-control study, erythrocyte membrane n-3 content was higher in fish-oil supplement users than in nonusers, but cognitive function did not differ significantly between groups. Total erythrocyte n-3 fatty acids and the ratio of docosahexaenoic acid to arachidonic acid was associated with better cognitive function in late life before and after adjustment for childhood IQ.

    Conclusions: Food supplement use and erythrocyte n-3 content are associated with better cognitive aging. If associations with n-3 content are causal, optimization of n-3 and n-6 fatty acid intakes could improve retention of cognitive function in old age.

    Original languageEnglish
    Pages (from-to)1650-1657
    Number of pages7
    JournalThe American Journal of Clinical Nutrition
    Volume80
    Issue number6
    Publication statusPublished - Dec 2004

    Keywords

    • childhood intelligence
    • aging
    • cognition
    • food supplement
    • diet
    • erythrocyte
    • n-3 polyunsaturated fatty acids
    • ALZHEIMERS-DISEASE
    • ARACHIDONIC-ACID
    • DIETARY-INTAKE
    • RISK-FACTORS
    • DEMENTIA
    • HEALTH
    • WOMEN
    • PERFORMANCE
    • IMPAIRMENT
    • VITAMIN

    Cite this

    Cognitive aging, childhood intelligence, and the use of food supplements: Possible involvement of n-3 fatty acids. / Whalley, Lawrence Jeffrey; Fox, Helen Catherine; Wahle, K. J.; Starr, J. M.; Deary, I. J.

    In: The American Journal of Clinical Nutrition, Vol. 80, No. 6, 12.2004, p. 1650-1657.

    Research output: Contribution to journalArticle

    Whalley, Lawrence Jeffrey ; Fox, Helen Catherine ; Wahle, K. J. ; Starr, J. M. ; Deary, I. J. / Cognitive aging, childhood intelligence, and the use of food supplements: Possible involvement of n-3 fatty acids. In: The American Journal of Clinical Nutrition. 2004 ; Vol. 80, No. 6. pp. 1650-1657.
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    abstract = "Background: Food supplement use is widely promoted, but little is known about the cognitive effects of food supplements.Objective: We examined the effects of food supplement use on cognitive aging.Design: This was an observational study of subjects born in 1936 whose mental ability was tested in 1947 and who were followed up in 2000-2001, at which time cognition, diet, food supplement use, and risk factors for vascular disease were assessed. In a nested case-control study, fish-oil users were matched with nonusers, and cognitive function was related to erythrocyte n-3 fatty acid composition.Results: Childhood intelligence quotient (IQ) did not differ significantly by category of food supplement use (ie, none, fish oil, vitamins, and other). At the age of 64 y, cognitive function was higher in food supplement users than in nonusers before adjustment for childhood IQ. After adjustment for childhood IQ, digit symbol (mental speed) test scores were higher in food supplement users. Fish-oil supplement users consumed more vitamin C and vegetable and cereal fiber than did non-supplement-users. In a nested case-control study, erythrocyte membrane n-3 content was higher in fish-oil supplement users than in nonusers, but cognitive function did not differ significantly between groups. Total erythrocyte n-3 fatty acids and the ratio of docosahexaenoic acid to arachidonic acid was associated with better cognitive function in late life before and after adjustment for childhood IQ.Conclusions: Food supplement use and erythrocyte n-3 content are associated with better cognitive aging. If associations with n-3 content are causal, optimization of n-3 and n-6 fatty acid intakes could improve retention of cognitive function in old age.",
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    TY - JOUR

    T1 - Cognitive aging, childhood intelligence, and the use of food supplements: Possible involvement of n-3 fatty acids

    AU - Whalley, Lawrence Jeffrey

    AU - Fox, Helen Catherine

    AU - Wahle, K. J.

    AU - Starr, J. M.

    AU - Deary, I. J.

    PY - 2004/12

    Y1 - 2004/12

    N2 - Background: Food supplement use is widely promoted, but little is known about the cognitive effects of food supplements.Objective: We examined the effects of food supplement use on cognitive aging.Design: This was an observational study of subjects born in 1936 whose mental ability was tested in 1947 and who were followed up in 2000-2001, at which time cognition, diet, food supplement use, and risk factors for vascular disease were assessed. In a nested case-control study, fish-oil users were matched with nonusers, and cognitive function was related to erythrocyte n-3 fatty acid composition.Results: Childhood intelligence quotient (IQ) did not differ significantly by category of food supplement use (ie, none, fish oil, vitamins, and other). At the age of 64 y, cognitive function was higher in food supplement users than in nonusers before adjustment for childhood IQ. After adjustment for childhood IQ, digit symbol (mental speed) test scores were higher in food supplement users. Fish-oil supplement users consumed more vitamin C and vegetable and cereal fiber than did non-supplement-users. In a nested case-control study, erythrocyte membrane n-3 content was higher in fish-oil supplement users than in nonusers, but cognitive function did not differ significantly between groups. Total erythrocyte n-3 fatty acids and the ratio of docosahexaenoic acid to arachidonic acid was associated with better cognitive function in late life before and after adjustment for childhood IQ.Conclusions: Food supplement use and erythrocyte n-3 content are associated with better cognitive aging. If associations with n-3 content are causal, optimization of n-3 and n-6 fatty acid intakes could improve retention of cognitive function in old age.

    AB - Background: Food supplement use is widely promoted, but little is known about the cognitive effects of food supplements.Objective: We examined the effects of food supplement use on cognitive aging.Design: This was an observational study of subjects born in 1936 whose mental ability was tested in 1947 and who were followed up in 2000-2001, at which time cognition, diet, food supplement use, and risk factors for vascular disease were assessed. In a nested case-control study, fish-oil users were matched with nonusers, and cognitive function was related to erythrocyte n-3 fatty acid composition.Results: Childhood intelligence quotient (IQ) did not differ significantly by category of food supplement use (ie, none, fish oil, vitamins, and other). At the age of 64 y, cognitive function was higher in food supplement users than in nonusers before adjustment for childhood IQ. After adjustment for childhood IQ, digit symbol (mental speed) test scores were higher in food supplement users. Fish-oil supplement users consumed more vitamin C and vegetable and cereal fiber than did non-supplement-users. In a nested case-control study, erythrocyte membrane n-3 content was higher in fish-oil supplement users than in nonusers, but cognitive function did not differ significantly between groups. Total erythrocyte n-3 fatty acids and the ratio of docosahexaenoic acid to arachidonic acid was associated with better cognitive function in late life before and after adjustment for childhood IQ.Conclusions: Food supplement use and erythrocyte n-3 content are associated with better cognitive aging. If associations with n-3 content are causal, optimization of n-3 and n-6 fatty acid intakes could improve retention of cognitive function in old age.

    KW - childhood intelligence

    KW - aging

    KW - cognition

    KW - food supplement

    KW - diet

    KW - erythrocyte

    KW - n-3 polyunsaturated fatty acids

    KW - ALZHEIMERS-DISEASE

    KW - ARACHIDONIC-ACID

    KW - DIETARY-INTAKE

    KW - RISK-FACTORS

    KW - DEMENTIA

    KW - HEALTH

    KW - WOMEN

    KW - PERFORMANCE

    KW - IMPAIRMENT

    KW - VITAMIN

    M3 - Article

    VL - 80

    SP - 1650

    EP - 1657

    JO - The American Journal of Clinical Nutrition

    JF - The American Journal of Clinical Nutrition

    SN - 0002-9165

    IS - 6

    ER -