Cognitive control mechanisms revealed by ERP and fMRI

Evidence from repeated task-switching

Rachel Swainson, R. Cunnington, G. M. Jackson, C. Rorden, A. M. Peters, P. G. Morris, S. R. Jackson

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

We investigated the extent to which a common neural mechanism is involved in task set-switching and response withholding, factors that are frequently confounded in task-switching and go/no-go paradigms. Subjects' brain activity was measured using event-related electrical potentials (ERPs) and event-related functional MRI (fMRI) neuroimaging in separate studies using the same cognitive paradigm. Subjects made compatible left/right keypress responses to left/right arrow stimuli of 1000 msec duration; they switched every two trials between responding at stimulus onset (GO task-green arrows) and stimulus offset (WAIT task-red arrows). Withholding an immediate response (WAIT vs. GO) elicited an enhancement of the frontal N2 ERP and lateral PFC activation of the right hemisphere, both previously associated with the "no-go" response, but only on switch trials. Task-switching (switch vs. nonswitch) was associated with frontal N2 amplification and right hemisphere ventrolateral PFC activation, but only for the WAIT task. The anterior cingulate cortex (ACC) was the only brain region to be activated for both types of task switch, but this activation was located more rostrally for the WAIT than for the GO switch trials. We conclude that the frontal N2 ERP and lateral PFC activation are not markers for withholding an immediate response or switching tasks per se, hut are associated with switching into a response-suppression mode. Different regions within the ACC may be involved in two processes integral to task-switching: processing response conflict (rostral ACC) and overcoming prior response suppression (caudal ACC).

Original languageEnglish
Pages (from-to)785-799
Number of pages14
JournalJournal of Cognitive Neuroscience
Volume15
Issue number6
DOIs
Publication statusPublished - Aug 2003

Keywords

  • event-related fMRI
  • inferior prefrontal cortex
  • anterior cingulate cortex
  • functional MRI
  • inhibition
  • go
  • brain
  • activation
  • selection
  • movement

Cite this

Swainson, R., Cunnington, R., Jackson, G. M., Rorden, C., Peters, A. M., Morris, P. G., & Jackson, S. R. (2003). Cognitive control mechanisms revealed by ERP and fMRI: Evidence from repeated task-switching. Journal of Cognitive Neuroscience, 15(6), 785-799. https://doi.org/10.1162/089892903322370717

Cognitive control mechanisms revealed by ERP and fMRI : Evidence from repeated task-switching. / Swainson, Rachel; Cunnington, R.; Jackson, G. M.; Rorden, C.; Peters, A. M.; Morris, P. G.; Jackson, S. R.

In: Journal of Cognitive Neuroscience, Vol. 15, No. 6, 08.2003, p. 785-799.

Research output: Contribution to journalArticle

Swainson, R, Cunnington, R, Jackson, GM, Rorden, C, Peters, AM, Morris, PG & Jackson, SR 2003, 'Cognitive control mechanisms revealed by ERP and fMRI: Evidence from repeated task-switching', Journal of Cognitive Neuroscience, vol. 15, no. 6, pp. 785-799. https://doi.org/10.1162/089892903322370717
Swainson, Rachel ; Cunnington, R. ; Jackson, G. M. ; Rorden, C. ; Peters, A. M. ; Morris, P. G. ; Jackson, S. R. / Cognitive control mechanisms revealed by ERP and fMRI : Evidence from repeated task-switching. In: Journal of Cognitive Neuroscience. 2003 ; Vol. 15, No. 6. pp. 785-799.
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