Cognitive Impairment in Major Depression (the fMRI perspective).

K. P. Ebmeier, E. J. Rose, John Douglas Steele

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    Cognitive impairment in depression may be one of the more practically important aspects of the illness, responsible for much of its morbidity. It also is at the heart of its psychopathology, may contribute to strategies of treatment, and may give us a more easily quantifiable measure of impaired function to correlate with brain activity. Functional magnetic resonance imaging (fMRI) is ideally suited to examine brain function in depression. It has the correct time window to repeatedly sample cognitive task performance; it does not require exposure to radioactive tracers and can therefore be repeated many times; it also can be linked with high resolution structural images acquired in the same imaging session that help identify the regions of activation and support the spatial transformation necessary to compare the scans of different subjects. fMRI has already produced a series of consistent results in depression, identifying increased activity of rostral anterior cingulate and other medial prefrontal structures during effortful tasks and on occasion also increased dorsolateral prefrontal activity, suggesting increased possibly compensatory activity to maintain task performance. Investigating the interplay between limbic (orbitomedial) and 'cognitive' dorsolateral structures clearly has the potential to clarify important illness mechanisms of depressive illness.

    Original languageEnglish
    Pages (from-to)87-92
    Number of pages5
    JournalNeurotoxicity Research
    Volume10
    Issue number2
    Publication statusPublished - 2006

    Keywords

    • functional magnetic resonance imaging
    • depression
    • working memory
    • SSRI
    • EVENT-RELATED FMRI
    • N-BACK TASK
    • UNIPOLAR DEPRESSION
    • PREFRONTAL CORTEX
    • MOOD DISORDERS
    • WORKING-MEMORY
    • VERBAL MEMORY
    • REWARD
    • PERFORMANCE
    • ACTIVATION

    Cite this

    Ebmeier, K. P., Rose, E. J., & Steele, J. D. (2006). Cognitive Impairment in Major Depression (the fMRI perspective). Neurotoxicity Research, 10(2), 87-92.