Cognitive performance in patients with COPD

D. S. Postma, J. J. W. Liesker, R. J. Beukema, N. H. T. ten Hacken, Thys Van Der Molen, R. A. Riemersma, E. H. van Zomeren, H. A. M. Kerstjens

    Research output: Contribution to journalArticle

    99 Citations (Scopus)

    Abstract

    Background: Hypoxemic patients with Chronic Obstructive Pulmonary Disease (COPD) have impaired cognitive performance. These neuropsychological impairments are related to the degree of hypoxemia. So far, cognitive performance has not been tested in non-hypoxemic patients with COPD.

    Methods: We recruited patients with stable COPD and PaO2 > 8.0 kPa (60 mmHg), as well as healthy subjects, who were matched for age, intelligence quotient (IQ), and level of education. Cognitive performance was studied by Stroop Colour Word Test, Trailmaking, digit-symbol of the Wechsler Adult Intelligence Scale, addition subtest of the Groningen Intelligence Test, and Story Recall.

    Results: Thirty patients with COPD (FEV1 49.8% pred, mean age 64.8 yr) and 20 healthy volunteers (65.6 yr) were enrolled. COPD patients performed significantly worse on trailmaking B, the digit-symbol test, and on the addition subtest. There was no significant correlation between the tests of cognitive performance and disease specific health status (Chronic Respiratory Questionnaire).

    Conclusions: We conclude that even non-hypoxemic patients with COPD show significant impairments in cognitive performance. These impairments are not associated with deteriorations in health related quality of life. Prospective evaluation of the impact of treatment on cognitive performance in non-hypoxemic patients with COPD would be a logical subsequent study. (C) 2003 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)351-356
    Number of pages5
    JournalRespiratory Medicine
    Volume98
    DOIs
    Publication statusPublished - 2004

    Keywords

    • cognitive disorder
    • chronic obstructive
    • pulmonary disease
    • non-hypoxemia
    • quality of life
    • OBSTRUCTIVE PULMONARY-DISEASE
    • PERIPHERAL MUSCLE WEAKNESS
    • OXYGEN-THERAPY
    • MEMORY IMPAIRMENT
    • DYSFUNCTION
    • HYPOXEMIA
    • EXERCISE
    • HYPOXIA
    • DECLINE

    Cite this

    Postma, D. S., Liesker, J. J. W., Beukema, R. J., ten Hacken, N. H. T., Van Der Molen, T., Riemersma, R. A., ... Kerstjens, H. A. M. (2004). Cognitive performance in patients with COPD. Respiratory Medicine, 98, 351-356. https://doi.org/10.1016/j.rmed.2003.11.004

    Cognitive performance in patients with COPD. / Postma, D. S.; Liesker, J. J. W.; Beukema, R. J.; ten Hacken, N. H. T.; Van Der Molen, Thys; Riemersma, R. A.; van Zomeren, E. H.; Kerstjens, H. A. M.

    In: Respiratory Medicine, Vol. 98, 2004, p. 351-356.

    Research output: Contribution to journalArticle

    Postma, DS, Liesker, JJW, Beukema, RJ, ten Hacken, NHT, Van Der Molen, T, Riemersma, RA, van Zomeren, EH & Kerstjens, HAM 2004, 'Cognitive performance in patients with COPD', Respiratory Medicine, vol. 98, pp. 351-356. https://doi.org/10.1016/j.rmed.2003.11.004
    Postma DS, Liesker JJW, Beukema RJ, ten Hacken NHT, Van Der Molen T, Riemersma RA et al. Cognitive performance in patients with COPD. Respiratory Medicine. 2004;98:351-356. https://doi.org/10.1016/j.rmed.2003.11.004
    Postma, D. S. ; Liesker, J. J. W. ; Beukema, R. J. ; ten Hacken, N. H. T. ; Van Der Molen, Thys ; Riemersma, R. A. ; van Zomeren, E. H. ; Kerstjens, H. A. M. / Cognitive performance in patients with COPD. In: Respiratory Medicine. 2004 ; Vol. 98. pp. 351-356.
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    abstract = "Background: Hypoxemic patients with Chronic Obstructive Pulmonary Disease (COPD) have impaired cognitive performance. These neuropsychological impairments are related to the degree of hypoxemia. So far, cognitive performance has not been tested in non-hypoxemic patients with COPD.Methods: We recruited patients with stable COPD and PaO2 > 8.0 kPa (60 mmHg), as well as healthy subjects, who were matched for age, intelligence quotient (IQ), and level of education. Cognitive performance was studied by Stroop Colour Word Test, Trailmaking, digit-symbol of the Wechsler Adult Intelligence Scale, addition subtest of the Groningen Intelligence Test, and Story Recall.Results: Thirty patients with COPD (FEV1 49.8{\%} pred, mean age 64.8 yr) and 20 healthy volunteers (65.6 yr) were enrolled. COPD patients performed significantly worse on trailmaking B, the digit-symbol test, and on the addition subtest. There was no significant correlation between the tests of cognitive performance and disease specific health status (Chronic Respiratory Questionnaire).Conclusions: We conclude that even non-hypoxemic patients with COPD show significant impairments in cognitive performance. These impairments are not associated with deteriorations in health related quality of life. Prospective evaluation of the impact of treatment on cognitive performance in non-hypoxemic patients with COPD would be a logical subsequent study. (C) 2003 Elsevier Ltd. All rights reserved.",
    keywords = "cognitive disorder, chronic obstructive, pulmonary disease, non-hypoxemia, quality of life, OBSTRUCTIVE PULMONARY-DISEASE, PERIPHERAL MUSCLE WEAKNESS, OXYGEN-THERAPY, MEMORY IMPAIRMENT, DYSFUNCTION, HYPOXEMIA, EXERCISE, HYPOXIA, DECLINE",
    author = "Postma, {D. S.} and Liesker, {J. J. W.} and Beukema, {R. J.} and {ten Hacken}, {N. H. T.} and {Van Der Molen}, Thys and Riemersma, {R. A.} and {van Zomeren}, {E. H.} and Kerstjens, {H. A. M.}",
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    T1 - Cognitive performance in patients with COPD

    AU - Postma, D. S.

    AU - Liesker, J. J. W.

    AU - Beukema, R. J.

    AU - ten Hacken, N. H. T.

    AU - Van Der Molen, Thys

    AU - Riemersma, R. A.

    AU - van Zomeren, E. H.

    AU - Kerstjens, H. A. M.

    PY - 2004

    Y1 - 2004

    N2 - Background: Hypoxemic patients with Chronic Obstructive Pulmonary Disease (COPD) have impaired cognitive performance. These neuropsychological impairments are related to the degree of hypoxemia. So far, cognitive performance has not been tested in non-hypoxemic patients with COPD.Methods: We recruited patients with stable COPD and PaO2 > 8.0 kPa (60 mmHg), as well as healthy subjects, who were matched for age, intelligence quotient (IQ), and level of education. Cognitive performance was studied by Stroop Colour Word Test, Trailmaking, digit-symbol of the Wechsler Adult Intelligence Scale, addition subtest of the Groningen Intelligence Test, and Story Recall.Results: Thirty patients with COPD (FEV1 49.8% pred, mean age 64.8 yr) and 20 healthy volunteers (65.6 yr) were enrolled. COPD patients performed significantly worse on trailmaking B, the digit-symbol test, and on the addition subtest. There was no significant correlation between the tests of cognitive performance and disease specific health status (Chronic Respiratory Questionnaire).Conclusions: We conclude that even non-hypoxemic patients with COPD show significant impairments in cognitive performance. These impairments are not associated with deteriorations in health related quality of life. Prospective evaluation of the impact of treatment on cognitive performance in non-hypoxemic patients with COPD would be a logical subsequent study. (C) 2003 Elsevier Ltd. All rights reserved.

    AB - Background: Hypoxemic patients with Chronic Obstructive Pulmonary Disease (COPD) have impaired cognitive performance. These neuropsychological impairments are related to the degree of hypoxemia. So far, cognitive performance has not been tested in non-hypoxemic patients with COPD.Methods: We recruited patients with stable COPD and PaO2 > 8.0 kPa (60 mmHg), as well as healthy subjects, who were matched for age, intelligence quotient (IQ), and level of education. Cognitive performance was studied by Stroop Colour Word Test, Trailmaking, digit-symbol of the Wechsler Adult Intelligence Scale, addition subtest of the Groningen Intelligence Test, and Story Recall.Results: Thirty patients with COPD (FEV1 49.8% pred, mean age 64.8 yr) and 20 healthy volunteers (65.6 yr) were enrolled. COPD patients performed significantly worse on trailmaking B, the digit-symbol test, and on the addition subtest. There was no significant correlation between the tests of cognitive performance and disease specific health status (Chronic Respiratory Questionnaire).Conclusions: We conclude that even non-hypoxemic patients with COPD show significant impairments in cognitive performance. These impairments are not associated with deteriorations in health related quality of life. Prospective evaluation of the impact of treatment on cognitive performance in non-hypoxemic patients with COPD would be a logical subsequent study. (C) 2003 Elsevier Ltd. All rights reserved.

    KW - cognitive disorder

    KW - chronic obstructive

    KW - pulmonary disease

    KW - non-hypoxemia

    KW - quality of life

    KW - OBSTRUCTIVE PULMONARY-DISEASE

    KW - PERIPHERAL MUSCLE WEAKNESS

    KW - OXYGEN-THERAPY

    KW - MEMORY IMPAIRMENT

    KW - DYSFUNCTION

    KW - HYPOXEMIA

    KW - EXERCISE

    KW - HYPOXIA

    KW - DECLINE

    U2 - 10.1016/j.rmed.2003.11.004

    DO - 10.1016/j.rmed.2003.11.004

    M3 - Article

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    SP - 351

    EP - 356

    JO - Respiratory Medicine

    JF - Respiratory Medicine

    SN - 0954-6111

    ER -