Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

Tina Habota*, Anca-Larisa Sandu, Gordon D. Waiter, Christopher J. McNeil, J. Douglas Steele, Jennifer A. Macfarlane, Heather C. Whalley, Ruth Valentine, Dawn Younie, Nichola Crouch, Emma L. Hawkins, Yoriko Hirose, Liana Romaniuk, Keith Milburn, Gordon Buchan, Tessa Coupar, Mairi Stirling, Jagpal Baljit, Beverly MacLennan, Lucasz PribaMatthew A. Harris, Jonathan D. Hafferty, Mark J. Adams, Archie I. Campbell, Donald J. MacIntyre, Alison Pattie, Lee Murphy, Rebecca M. Reynolds, Rebecca Elliot, Ian S. Penton-Voak, Marcus R. Munafò, Kathryn L. Evans, Jonathan R. Seckl, Joanna M. Wardlaw, Stephen M. Lawrie, Christopher S. Haley, David J. Porteous, Ian J. Deary, Alison D. Murray, Andrew M. McIntosh

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the
GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.
Original languageEnglish
Article number185
JournalWellcome open research
Early online date25 Nov 2019
DOIs
Publication statusE-pub ahead of print - 25 Nov 2019

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Neuroimaging
Scotland
Health
Depression
Brain
Family Health
Imaging techniques
Magnetic resonance
Genes
Gene-Environment Interaction
History
Health Resources
Major Depressive Disorder
Economics
Mood Disorders
Personality
Life Style
Magnetic Resonance Imaging
Parturition
Psychology

Keywords

  • cognition
  • depression
  • Generation Scotland
  • longitudinal
  • neuroimaging
  • psychological resilience

Cite this

Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study : A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments. / Habota, Tina; Sandu, Anca-Larisa; Waiter, Gordon D.; McNeil, Christopher J.; Steele, J. Douglas; Macfarlane, Jennifer A.; Whalley, Heather C.; Valentine, Ruth; Younie, Dawn; Crouch, Nichola; Hawkins, Emma L.; Hirose, Yoriko; Romaniuk, Liana; Milburn, Keith; Buchan, Gordon; Coupar, Tessa; Stirling, Mairi; Baljit, Jagpal; MacLennan, Beverly; Priba, Lucasz; Harris, Matthew A.; Hafferty, Jonathan D.; Adams, Mark J.; Campbell, Archie I.; MacIntyre, Donald J.; Pattie, Alison ; Murphy, Lee; Reynolds, Rebecca M.; Elliot, Rebecca; Penton-Voak, Ian S.; Munafò, Marcus R.; Evans, Kathryn L.; Seckl, Jonathan R.; Wardlaw, Joanna M.; Lawrie, Stephen M. ; Haley, Christopher S.; Porteous, David J. ; Deary, Ian J.; Murray, Alison D.; McIntosh, Andrew M.

In: Wellcome open research, 25.11.2019.

Research output: Contribution to journalArticle

Habota, T, Sandu, A-L, Waiter, GD, McNeil, CJ, Steele, JD, Macfarlane, JA, Whalley, HC, Valentine, R, Younie, D, Crouch, N, Hawkins, EL, Hirose, Y, Romaniuk, L, Milburn, K, Buchan, G, Coupar, T, Stirling, M, Baljit, J, MacLennan, B, Priba, L, Harris, MA, Hafferty, JD, Adams, MJ, Campbell, AI, MacIntyre, DJ, Pattie, A, Murphy, L, Reynolds, RM, Elliot, R, Penton-Voak, IS, Munafò, MR, Evans, KL, Seckl, JR, Wardlaw, JM, Lawrie, SM, Haley, CS, Porteous, DJ, Deary, IJ, Murray, AD & McIntosh, AM 2019, 'Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments', Wellcome open research. https://doi.org/10.12688/wellcomeopenres.15538.1
Habota, Tina ; Sandu, Anca-Larisa ; Waiter, Gordon D. ; McNeil, Christopher J. ; Steele, J. Douglas ; Macfarlane, Jennifer A. ; Whalley, Heather C. ; Valentine, Ruth ; Younie, Dawn ; Crouch, Nichola ; Hawkins, Emma L. ; Hirose, Yoriko ; Romaniuk, Liana ; Milburn, Keith ; Buchan, Gordon ; Coupar, Tessa ; Stirling, Mairi ; Baljit, Jagpal ; MacLennan, Beverly ; Priba, Lucasz ; Harris, Matthew A. ; Hafferty, Jonathan D. ; Adams, Mark J. ; Campbell, Archie I. ; MacIntyre, Donald J. ; Pattie, Alison ; Murphy, Lee ; Reynolds, Rebecca M. ; Elliot, Rebecca ; Penton-Voak, Ian S. ; Munafò, Marcus R. ; Evans, Kathryn L. ; Seckl, Jonathan R. ; Wardlaw, Joanna M. ; Lawrie, Stephen M. ; Haley, Christopher S. ; Porteous, David J. ; Deary, Ian J. ; Murray, Alison D. ; McIntosh, Andrew M. / Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study : A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments. In: Wellcome open research. 2019.
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abstract = "STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at theGS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.",
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author = "Tina Habota and Anca-Larisa Sandu and Waiter, {Gordon D.} and McNeil, {Christopher J.} and Steele, {J. Douglas} and Macfarlane, {Jennifer A.} and Whalley, {Heather C.} and Ruth Valentine and Dawn Younie and Nichola Crouch and Hawkins, {Emma L.} and Yoriko Hirose and Liana Romaniuk and Keith Milburn and Gordon Buchan and Tessa Coupar and Mairi Stirling and Jagpal Baljit and Beverly MacLennan and Lucasz Priba and Harris, {Matthew A.} and Hafferty, {Jonathan D.} and Adams, {Mark J.} and Campbell, {Archie I.} and MacIntyre, {Donald J.} and Alison Pattie and Lee Murphy and Reynolds, {Rebecca M.} and Rebecca Elliot and Penton-Voak, {Ian S.} and Munaf{\`o}, {Marcus R.} and Evans, {Kathryn L.} and Seckl, {Jonathan R.} and Wardlaw, {Joanna M.} and Lawrie, {Stephen M.} and Haley, {Christopher S.} and Porteous, {David J.} and Deary, {Ian J.} and Murray, {Alison D.} and McIntosh, {Andrew M.}",
note = "Grant information: STRADL is supported by the Wellcome Trust through a Strategic Award (104036/Z/14/Z). GS:SFHS received core support from the CSO of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). ADM is supported by Innovate UK, the European Commission, the Scottish Funding Council via the Scottish Imaging Network SINAPSE, and the CSO. HCW is supported by a JMAS SIM Fellowship from the Royal College of Physicians of Edinburgh, by an ESAT College Fellowship from the University of Edinburgh, and has received previous funding from the Sackler Trust. LR has previously received financial support from Pfizer (formerly Wyeth) in relation to imaging studies of people with schizophrenia and bipolar disorder. JDH is supported by the MRC. DJM is an NRS Clinician, funded by the CSO. RMR is supported by the British Heart Foundation. ISP-V and MRM are supported by the NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health; and MRM is also supported by the MRC (MC_UU_12013/6). JMW is supported by MRC UK Dementia Research Institute and MRC Centre and project grants, EPSRC, Fondation Leducq, Stroke Association, British Heart Foundation, Alzheimer Society, and the European Union H2020 PHC-03-15 SVDs@Target grant agreement (666881). DJP is supported by Wellcome Trust Longitudinal Population Study funding (216767/Z/19/Z) the Eva Lester bequest to the University of Edinburgh. AMM is additionally supported by the MRC (MC_PC_17209, MC_PC_MR/R01910X/1, MR/S035818/1), The Wellcome Trust (216767/Z/19/Z ), The Sackler Trust, and has previously received research funding from Pfizer, Eli Lilly, and Janssen. Both AMM and IJD are members of The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1); funding from the BBSRC and MRC is gratefully acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript",
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month = "11",
day = "25",
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TY - JOUR

T1 - Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study

T2 - A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

AU - Habota, Tina

AU - Sandu, Anca-Larisa

AU - Waiter, Gordon D.

AU - McNeil, Christopher J.

AU - Steele, J. Douglas

AU - Macfarlane, Jennifer A.

AU - Whalley, Heather C.

AU - Valentine, Ruth

AU - Younie, Dawn

AU - Crouch, Nichola

AU - Hawkins, Emma L.

AU - Hirose, Yoriko

AU - Romaniuk, Liana

AU - Milburn, Keith

AU - Buchan, Gordon

AU - Coupar, Tessa

AU - Stirling, Mairi

AU - Baljit, Jagpal

AU - MacLennan, Beverly

AU - Priba, Lucasz

AU - Harris, Matthew A.

AU - Hafferty, Jonathan D.

AU - Adams, Mark J.

AU - Campbell, Archie I.

AU - MacIntyre, Donald J.

AU - Pattie, Alison

AU - Murphy, Lee

AU - Reynolds, Rebecca M.

AU - Elliot, Rebecca

AU - Penton-Voak, Ian S.

AU - Munafò, Marcus R.

AU - Evans, Kathryn L.

AU - Seckl, Jonathan R.

AU - Wardlaw, Joanna M.

AU - Lawrie, Stephen M.

AU - Haley, Christopher S.

AU - Porteous, David J.

AU - Deary, Ian J.

AU - Murray, Alison D.

AU - McIntosh, Andrew M.

N1 - Grant information: STRADL is supported by the Wellcome Trust through a Strategic Award (104036/Z/14/Z). GS:SFHS received core support from the CSO of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006). ADM is supported by Innovate UK, the European Commission, the Scottish Funding Council via the Scottish Imaging Network SINAPSE, and the CSO. HCW is supported by a JMAS SIM Fellowship from the Royal College of Physicians of Edinburgh, by an ESAT College Fellowship from the University of Edinburgh, and has received previous funding from the Sackler Trust. LR has previously received financial support from Pfizer (formerly Wyeth) in relation to imaging studies of people with schizophrenia and bipolar disorder. JDH is supported by the MRC. DJM is an NRS Clinician, funded by the CSO. RMR is supported by the British Heart Foundation. ISP-V and MRM are supported by the NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health; and MRM is also supported by the MRC (MC_UU_12013/6). JMW is supported by MRC UK Dementia Research Institute and MRC Centre and project grants, EPSRC, Fondation Leducq, Stroke Association, British Heart Foundation, Alzheimer Society, and the European Union H2020 PHC-03-15 SVDs@Target grant agreement (666881). DJP is supported by Wellcome Trust Longitudinal Population Study funding (216767/Z/19/Z) the Eva Lester bequest to the University of Edinburgh. AMM is additionally supported by the MRC (MC_PC_17209, MC_PC_MR/R01910X/1, MR/S035818/1), The Wellcome Trust (216767/Z/19/Z ), The Sackler Trust, and has previously received research funding from Pfizer, Eli Lilly, and Janssen. Both AMM and IJD are members of The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (MR/K026992/1); funding from the BBSRC and MRC is gratefully acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

PY - 2019/11/25

Y1 - 2019/11/25

N2 - STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at theGS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.

AB - STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at theGS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.

KW - cognition

KW - depression

KW - Generation Scotland

KW - longitudinal

KW - neuroimaging

KW - psychological resilience

U2 - 10.12688/wellcomeopenres.15538.1

DO - 10.12688/wellcomeopenres.15538.1

M3 - Article

JO - Wellcome open research

JF - Wellcome open research

SN - 2398-502X

M1 - 185

ER -