Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Manuel A. R. Ferreira; Michael C. O'Donovan; Yan A. Meng; Ian R. Jones; Douglas M. Ruderfer; Lisa Jones; Jinbo Fan; George Kirov; Roy H. Perlis; Elaine K. Green; Jordan W. Smoller; Detelina Grozeva; Jennifer Stone; Ivan Nikolov; Kimberly Chambert; Marian L. Hamshere; Vishwajit L. Nimgaonkar; Valentina Moskvina; Michael E. Thase; Sian Caesar; Gary S. Sachs; Jennifer Franklin; Katherine Gordon-Smith; Kristin G. Ardlie; Stacey B. Gabriel; Christine Fraser; Brendan Blumenstiel; Matthew Defelice; Gerome Breen; Michael Gill; Derek W. Morris; Amanda Elkin; Walter J. Muir; Kevin A. McGhee; Richard Williamson; Donald J. MacIntyre; Alan W. MacLean; David St Clair; Michelle Robinson; Margaret Van Beck; Ana C. P. Pereira; Radhika Kandaswamy; Andrew McQuillin; David A. Collier; Nicholas J. Bass; Allan H. Young; Jacob Lawrence; I. Nicol Ferrier; Adebayo Anjorin; Anne Farmer; Wellcome Trust Case Control Consortium

doi:10.1038/ng.209

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Manuel A. R. Ferreira, Michael C. O'Donovan, Yan A. Meng, Ian R. Jones, Douglas M. Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H. Perlis, Elaine K. Green, Jordan W. Smoller, Detelina Grozeva, Jennifer Stone, Ivan Nikolov, Kimberly Chambert, Marian L. Hamshere, Vishwajit L. Nimgaonkar, Valentina Moskvina, Michael E. Thase, Sian CaesarGary S. Sachs, Jennifer Franklin, Katherine Gordon-Smith, Kristin G. Ardlie, Stacey B. Gabriel, Christine Fraser, Brendan Blumenstiel, Matthew Defelice, Gerome Breen, Michael Gill, Derek W. Morris, Amanda Elkin, Walter J. Muir, Kevin A. McGhee, Richard Williamson, Donald J. MacIntyre, Alan W. MacLean, David St Clair, Michelle Robinson, Margaret Van Beck, Ana C. P. Pereira, Radhika Kandaswamy, Andrew McQuillin, David A. Collier, Nicholas J. Bass, Allan H. Young, Jacob Lawrence, I. Nicol Ferrier, Adebayo Anjorin, Anne Farmer, Wellcome Trust Case Control Consortium

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

953 Citations (Scopus)

Abstract

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

Original language	English
Pages (from-to)	1056-1058
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	9
Early online date	17 Aug 2008
DOIs	https://doi.org/10.1038/ng.209
Publication status	Published - Sep 2008

Keywords

loci
diseases
ranvier
genes

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Ferreira, M. A. R., O'Donovan, M. C., Meng, Y. A., Jones, I. R., Ruderfer, D. M., Jones, L., Fan, J., Kirov, G., Perlis, R. H., Green, E. K., Smoller, J. W., Grozeva, D., Stone, J., Nikolov, I., Chambert, K., Hamshere, M. L., Nimgaonkar, V. L., Moskvina, V., Thase, M. E., ... Wellcome Trust Case Control Consortium (2008). Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics, 40(9), 1056-1058. https://doi.org/10.1038/ng.209

Ferreira, MAR, O'Donovan, MC, Meng, YA, Jones, IR, Ruderfer, DM, Jones, L, Fan, J, Kirov, G, Perlis, RH, Green, EK, Smoller, JW, Grozeva, D, Stone, J, Nikolov, I, Chambert, K, Hamshere, ML, Nimgaonkar, VL, Moskvina, V, Thase, ME, Caesar, S, Sachs, GS, Franklin, J, Gordon-Smith, K, Ardlie, KG, Gabriel, SB, Fraser, C, Blumenstiel, B, Defelice, M, Breen, G, Gill, M, Morris, DW, Elkin, A, Muir, WJ, McGhee, KA, Williamson, R, MacIntyre, DJ, MacLean, AW, Clair, DS, Robinson, M, Van Beck, M, Pereira, ACP, Kandaswamy, R, McQuillin, A, Collier, DA, Bass, NJ, Young, AH, Lawrence, J, Ferrier, IN, Anjorin, A, Farmer, A & Wellcome Trust Case Control Consortium 2008, 'Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder', Nature Genetics, vol. 40, no. 9, pp. 1056-1058. https://doi.org/10.1038/ng.209

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abstract = "To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder. ",

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AU - Ruderfer, Douglas M.

AU - Jones, Lisa

AU - Fan, Jinbo

AU - Kirov, George

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AU - Green, Elaine K.

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AU - Thase, Michael E.

AU - Caesar, Sian

AU - Sachs, Gary S.

AU - Franklin, Jennifer

AU - Gordon-Smith, Katherine

AU - Ardlie, Kristin G.

AU - Gabriel, Stacey B.

AU - Fraser, Christine

AU - Blumenstiel, Brendan

AU - Defelice, Matthew

AU - Breen, Gerome

AU - Gill, Michael

AU - Morris, Derek W.

AU - Elkin, Amanda

AU - Muir, Walter J.

AU - McGhee, Kevin A.

AU - Williamson, Richard

AU - MacIntyre, Donald J.

AU - MacLean, Alan W.

AU - Clair, David St

AU - Robinson, Michelle

AU - Van Beck, Margaret

AU - Pereira, Ana C. P.

AU - Kandaswamy, Radhika

AU - McQuillin, Andrew

AU - Collier, David A.

AU - Bass, Nicholas J.

AU - Young, Allan H.

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AU - Farmer, Anne

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AB - To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

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ER -

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

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