Collective response of self-organized clusters of mechanosensitive channels

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Abstract

Mechanosensitive channels are ion channels activated by membrane tension. We investigate the influence of the spatial distribution of bacterial mechanosensitive channels on activation (gating). Based on elastic short-range interactions we map this physical process onto an Ising-like model, which enables us to predict the clustering of channels and the effects of clustering on their gating. We conclude that the aggregation of channels and the consequent interactions among them leads to a global cooperative gating behavior with potentially dramatic consequences for the cell.

Original languageEnglish
Article number020901(R)
Number of pages4
JournalPhysical Review. E, Statistical, Nonlinear and Soft Matter Physics
Volume83
Issue number2
DOIs
Publication statusPublished - 2011

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Clustering
Cooperative Behavior
Ion Channels
Physical process
Interaction
Spatial Distribution
Ising
Activation
Aggregation
Membrane
Predict
Cell
Range of data
Ising model
spatial distribution
interactions
activation
membranes
cells
Model

Keywords

  • bacteria
  • proteins
  • model

Cite this

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title = "Collective response of self-organized clusters of mechanosensitive channels",
abstract = "Mechanosensitive channels are ion channels activated by membrane tension. We investigate the influence of the spatial distribution of bacterial mechanosensitive channels on activation (gating). Based on elastic short-range interactions we map this physical process onto an Ising-like model, which enables us to predict the clustering of channels and the effects of clustering on their gating. We conclude that the aggregation of channels and the consequent interactions among them leads to a global cooperative gating behavior with potentially dramatic consequences for the cell.",
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author = "Ksenia Guseva and Marco Thiel and Samantha Miller and Celso Grebogi and {de Moura}, {Alessandro Paula Servio} and Ian Booth",
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language = "English",
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journal = "Physical Review. E, Statistical, Nonlinear and Soft Matter Physics",
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T1 - Collective response of self-organized clusters of mechanosensitive channels

AU - Guseva, Ksenia

AU - Thiel, Marco

AU - Miller, Samantha

AU - Grebogi, Celso

AU - de Moura, Alessandro Paula Servio

AU - Booth, Ian

PY - 2011

Y1 - 2011

N2 - Mechanosensitive channels are ion channels activated by membrane tension. We investigate the influence of the spatial distribution of bacterial mechanosensitive channels on activation (gating). Based on elastic short-range interactions we map this physical process onto an Ising-like model, which enables us to predict the clustering of channels and the effects of clustering on their gating. We conclude that the aggregation of channels and the consequent interactions among them leads to a global cooperative gating behavior with potentially dramatic consequences for the cell.

AB - Mechanosensitive channels are ion channels activated by membrane tension. We investigate the influence of the spatial distribution of bacterial mechanosensitive channels on activation (gating). Based on elastic short-range interactions we map this physical process onto an Ising-like model, which enables us to predict the clustering of channels and the effects of clustering on their gating. We conclude that the aggregation of channels and the consequent interactions among them leads to a global cooperative gating behavior with potentially dramatic consequences for the cell.

KW - bacteria

KW - proteins

KW - model

U2 - 10.1103/PhysRevE.83.020901

DO - 10.1103/PhysRevE.83.020901

M3 - Article

VL - 83

JO - Physical Review. E, Statistical, Nonlinear and Soft Matter Physics

JF - Physical Review. E, Statistical, Nonlinear and Soft Matter Physics

SN - 1539-3755

IS - 2

M1 - 020901(R)

ER -