Colonic bacterial metabolites and human health

Wendy R. Russell; Lesley Hoyles; Harry J. Flint; Marc Emmanuel Dumas

doi:10.1016/j.mib.2013.07.002

Colonic bacterial metabolites and human health

Wendy R. Russell, Lesley Hoyles, Harry J. Flint^*, Marc Emmanuel Dumas

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Review article › peer-review

242 Citations (Scopus)

Abstract

The influence of the microbial-mammalian metabolic axis is becoming increasingly important for human health. Bacterial fermentation of carbohydrates (CHOs) and proteins produces short-chain fatty acids (SCFA) and a range of other metabolites including those from aromatic amino acid (AAA) fermentation. SCFA influence host health as energy sources and via multiple signalling mechanisms. Bacterial transformation of fibre-related phytochemicals is associated with a reduced incidence of several chronic diseases. The 'gut-liver axis' is an emerging area of study. Microbial deconjugation of xenobiotics and release of aromatic moieties into the colon can have a wide range of physiological consequences. In addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention.

Original language	English
Pages (from-to)	246-254
Number of pages	9
Journal	Current Opinion in Microbiology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.mib.2013.07.002
Publication status	Published - Jun 2013

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10.1016/j.mib.2013.07.002

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title = "Colonic bacterial metabolites and human health",

abstract = "The influence of the microbial-mammalian metabolic axis is becoming increasingly important for human health. Bacterial fermentation of carbohydrates (CHOs) and proteins produces short-chain fatty acids (SCFA) and a range of other metabolites including those from aromatic amino acid (AAA) fermentation. SCFA influence host health as energy sources and via multiple signalling mechanisms. Bacterial transformation of fibre-related phytochemicals is associated with a reduced incidence of several chronic diseases. The 'gut-liver axis' is an emerging area of study. Microbial deconjugation of xenobiotics and release of aromatic moieties into the colon can have a wide range of physiological consequences. In addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention.",

author = "Russell, {Wendy R.} and Lesley Hoyles and Flint, {Harry J.} and Dumas, {Marc Emmanuel}",

note = "Acknowledgements LH is funded by EU-FP7 METACARDIS (HEALTH-F4-2012-305312), M-E.D. is funded by Nestl{\'e}, Institut M{\'e}rieux and EU-FP7 (METACARDIS). HF and WR acknowledge support from the Scottish Government (RESAS).",

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AU - Russell, Wendy R.

AU - Hoyles, Lesley

AU - Flint, Harry J.

AU - Dumas, Marc Emmanuel

N1 - Acknowledgements LH is funded by EU-FP7 METACARDIS (HEALTH-F4-2012-305312), M-E.D. is funded by Nestlé, Institut Mérieux and EU-FP7 (METACARDIS). HF and WR acknowledge support from the Scottish Government (RESAS).

PY - 2013/6

Y1 - 2013/6

N2 - The influence of the microbial-mammalian metabolic axis is becoming increasingly important for human health. Bacterial fermentation of carbohydrates (CHOs) and proteins produces short-chain fatty acids (SCFA) and a range of other metabolites including those from aromatic amino acid (AAA) fermentation. SCFA influence host health as energy sources and via multiple signalling mechanisms. Bacterial transformation of fibre-related phytochemicals is associated with a reduced incidence of several chronic diseases. The 'gut-liver axis' is an emerging area of study. Microbial deconjugation of xenobiotics and release of aromatic moieties into the colon can have a wide range of physiological consequences. In addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention.

AB - The influence of the microbial-mammalian metabolic axis is becoming increasingly important for human health. Bacterial fermentation of carbohydrates (CHOs) and proteins produces short-chain fatty acids (SCFA) and a range of other metabolites including those from aromatic amino acid (AAA) fermentation. SCFA influence host health as energy sources and via multiple signalling mechanisms. Bacterial transformation of fibre-related phytochemicals is associated with a reduced incidence of several chronic diseases. The 'gut-liver axis' is an emerging area of study. Microbial deconjugation of xenobiotics and release of aromatic moieties into the colon can have a wide range of physiological consequences. In addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention.

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DO - 10.1016/j.mib.2013.07.002

M3 - Review article

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VL - 16

SP - 246

EP - 254

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

IS - 3

ER -

Colonic bacterial metabolites and human health

Abstract

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