Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
- crosses, genetic
- insulin receptor substrate proteins
- intracellular signaling peptides and proteins
- Kaplan-Meiers estimate
- mice, inbred C57BL
- research design
- signal transduction