Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

Colin Selman, Steven Lingard, David Gems, Linda Partridge, Dominic J Withers

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
Original languageEnglish
Pages (from-to)1012
Number of pages1
JournalScience
Volume320
Issue number5879
DOIs
Publication statusPublished - 23 May 2008

Fingerprint

Homeostasis
Insulin Receptor Substrate Proteins
Food
Brain
Life Expectancy
Mutation

Keywords

  • animals
  • brain
  • crosses, genetic
  • diet
  • female
  • homeostasis
  • insulin receptor substrate proteins
  • intracellular signaling peptides and proteins
  • Kaplan-Meiers estimate
  • longevity
  • male
  • mice
  • mice, inbred C57BL
  • mutation
  • phosphoproteins
  • research design
  • signal transduction

Cite this

Selman, C., Lingard, S., Gems, D., Partridge, L., & Withers, D. J. (2008). Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis". Science, 320(5879), 1012. https://doi.org/10.1126/science.1152366

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis". / Selman, Colin; Lingard, Steven; Gems, David; Partridge, Linda; Withers, Dominic J.

In: Science, Vol. 320, No. 5879, 23.05.2008, p. 1012.

Research output: Contribution to journalArticle

Selman, C, Lingard, S, Gems, D, Partridge, L & Withers, DJ 2008, 'Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"', Science, vol. 320, no. 5879, pp. 1012. https://doi.org/10.1126/science.1152366
Selman C, Lingard S, Gems D, Partridge L, Withers DJ. Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis". Science. 2008 May 23;320(5879):1012. https://doi.org/10.1126/science.1152366
Selman, Colin ; Lingard, Steven ; Gems, David ; Partridge, Linda ; Withers, Dominic J. / Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis". In: Science. 2008 ; Vol. 320, No. 5879. pp. 1012.
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