Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

Colin Selman; Steven Lingard; David Gems; Linda Partridge; Dominic J Withers

doi:10.1126/science.1152366

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

Colin Selman, Steven Lingard, David Gems, Linda Partridge, Dominic J Withers

Aberdeen Centre For Environmental Sustainability

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.

Original language	English
Pages (from-to)	1012
Number of pages	1
Journal	Science
Volume	320
Issue number	5879
DOIs	https://doi.org/10.1126/science.1152366
Publication status	Published - 23 May 2008

Keywords

animals
brain
crosses, genetic
diet
female
homeostasis
insulin receptor substrate proteins
intracellular signaling peptides and proteins
Kaplan-Meiers estimate
longevity
male
mice
mice, inbred C57BL
mutation
phosphoproteins
research design
signal transduction

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10.1126/science.1152366

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title = "Comment on {"}Brain IRS2 signaling coordinates life span and nutrient homeostasis{"}",

abstract = "Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.",

keywords = "animals, brain, crosses, genetic, diet, female, homeostasis, insulin receptor substrate proteins, intracellular signaling peptides and proteins, Kaplan-Meiers estimate, longevity, male, mice, mice, inbred C57BL, mutation, phosphoproteins, research design, signal transduction",

author = "Colin Selman and Steven Lingard and David Gems and Linda Partridge and Withers, {Dominic J}",

year = "2008",

month = may,

day = "23",

doi = "10.1126/science.1152366",

language = "English",

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pages = "1012",

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TY - JOUR

T1 - Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

AU - Selman, Colin

AU - Lingard, Steven

AU - Gems, David

AU - Partridge, Linda

AU - Withers, Dominic J

PY - 2008/5/23

Y1 - 2008/5/23

N2 - Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.

AB - Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.

KW - animals

KW - brain

KW - crosses, genetic

KW - diet

KW - female

KW - homeostasis

KW - insulin receptor substrate proteins

KW - intracellular signaling peptides and proteins

KW - Kaplan-Meiers estimate

KW - longevity

KW - male

KW - mice

KW - mice, inbred C57BL

KW - mutation

KW - phosphoproteins

KW - research design

KW - signal transduction

U2 - 10.1126/science.1152366

DO - 10.1126/science.1152366

M3 - Article

C2 - 18497277

SN - 0036-8075

VL - 320

SP - 1012

JO - Science

JF - Science

IS - 5879

ER -

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

Abstract

Keywords

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