Commentary on

Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment

Research output: Contribution to journalComment/debate

Abstract

Gan et al. 1 describe the use of a simple linear measurement of the distance between the septal nuclei — the inter-septal distance (ISD) — in the basal forebrain as a sensitive and specific predictor of memory problems in a consecutive sample of hospital patients having brain computed tomography (CT). This is a novel and interesting finding and is based on the primary neuropathology of Alzheimer's Disease (AD), which, in addition to atrophy of the entorhinal cortex and hippocampus, is associated early in the disease course with basal forebrain atrophy. The basal forebrain consists of the nucleus accumbens, nucleus basilis (of Meynert), the diagonal band (of Broca), the substantia innominate, and the medially placed septal nuclei.2 These structures, which are located inferior to the head of the caudate and superior to the hypothalamus, are the main source of acetyl choline in the brain, a system that is known to fail in AD. The basal forebrain is highly interconnected with the hippocampi and entorhinal cortex. It is thus biologically plausible that atrophy of these structures, with resultant widening of the distance between the septal nuclei, might be an imaging feature of AD.
Original languageEnglish
Pages (from-to)923-924
Number of pages2
JournalClinical Radiology
Volume72
Issue number11
Early online date27 Jul 2017
DOIs
Publication statusPublished - Nov 2017

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Septum of Brain
Prefrontal Cortex
Alzheimer Disease
Atrophy
Septal Nuclei
Entorhinal Cortex
Hippocampus
Diagonal Band of Broca
Nucleus Accumbens
Brain
Choline
Hypothalamus
Tomography
Cognitive Dysfunction
Basal Forebrain

Keywords

  • Journal Article

Cite this

@article{44bdcf1cdad24d9bb38777d6105ae42a,
title = "Commentary on: Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment",
abstract = "Gan et al. 1 describe the use of a simple linear measurement of the distance between the septal nuclei — the inter-septal distance (ISD) — in the basal forebrain as a sensitive and specific predictor of memory problems in a consecutive sample of hospital patients having brain computed tomography (CT). This is a novel and interesting finding and is based on the primary neuropathology of Alzheimer's Disease (AD), which, in addition to atrophy of the entorhinal cortex and hippocampus, is associated early in the disease course with basal forebrain atrophy. The basal forebrain consists of the nucleus accumbens, nucleus basilis (of Meynert), the diagonal band (of Broca), the substantia innominate, and the medially placed septal nuclei.2 These structures, which are located inferior to the head of the caudate and superior to the hypothalamus, are the main source of acetyl choline in the brain, a system that is known to fail in AD. The basal forebrain is highly interconnected with the hippocampi and entorhinal cortex. It is thus biologically plausible that atrophy of these structures, with resultant widening of the distance between the septal nuclei, might be an imaging feature of AD.",
keywords = "Journal Article",
author = "Murray, {A D}",
year = "2017",
month = "11",
doi = "10.1016/j.crad.2017.06.119",
language = "English",
volume = "72",
pages = "923--924",
journal = "Clinical Radiology",
issn = "0009-9260",
publisher = "W.B. Saunders Ltd",
number = "11",

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T1 - Commentary on

T2 - Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment

AU - Murray, A D

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N2 - Gan et al. 1 describe the use of a simple linear measurement of the distance between the septal nuclei — the inter-septal distance (ISD) — in the basal forebrain as a sensitive and specific predictor of memory problems in a consecutive sample of hospital patients having brain computed tomography (CT). This is a novel and interesting finding and is based on the primary neuropathology of Alzheimer's Disease (AD), which, in addition to atrophy of the entorhinal cortex and hippocampus, is associated early in the disease course with basal forebrain atrophy. The basal forebrain consists of the nucleus accumbens, nucleus basilis (of Meynert), the diagonal band (of Broca), the substantia innominate, and the medially placed septal nuclei.2 These structures, which are located inferior to the head of the caudate and superior to the hypothalamus, are the main source of acetyl choline in the brain, a system that is known to fail in AD. The basal forebrain is highly interconnected with the hippocampi and entorhinal cortex. It is thus biologically plausible that atrophy of these structures, with resultant widening of the distance between the septal nuclei, might be an imaging feature of AD.

AB - Gan et al. 1 describe the use of a simple linear measurement of the distance between the septal nuclei — the inter-septal distance (ISD) — in the basal forebrain as a sensitive and specific predictor of memory problems in a consecutive sample of hospital patients having brain computed tomography (CT). This is a novel and interesting finding and is based on the primary neuropathology of Alzheimer's Disease (AD), which, in addition to atrophy of the entorhinal cortex and hippocampus, is associated early in the disease course with basal forebrain atrophy. The basal forebrain consists of the nucleus accumbens, nucleus basilis (of Meynert), the diagonal band (of Broca), the substantia innominate, and the medially placed septal nuclei.2 These structures, which are located inferior to the head of the caudate and superior to the hypothalamus, are the main source of acetyl choline in the brain, a system that is known to fail in AD. The basal forebrain is highly interconnected with the hippocampi and entorhinal cortex. It is thus biologically plausible that atrophy of these structures, with resultant widening of the distance between the septal nuclei, might be an imaging feature of AD.

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DO - 10.1016/j.crad.2017.06.119

M3 - Comment/debate

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JF - Clinical Radiology

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