Commentary: Sorting the wheat from the chaff: identifying demyelinating components of the myelin oligodendrocyte glycoprotein (MOG)-specific autoantibody repertoire

Emily Mathey, C. Breithaupt, Christopher Linington, A. S. Schubart

    Research output: Contribution to journalEditorial

    27 Citations (Scopus)

    Abstract

    Myelin oligodendrocyte glycoprotein (MOG) is the only myelin protein known to initiate a demyelinating autoantibody response in EAE, an animal model for multiple sclerosis (MS). The pathophysiological significance of MOG-specific autoantibodies in MS is, however, controversial, as high titer antibody responses to MOG are also found in many patients with non-demyelinating neurological diseases. In this issue of the European Journal of Immunology, von Budingen et al. demonstrate that demyelination in a primate model of MOG-induced EAE is mediated by MOG-specific antibodies directed against discontinuous, rather than linear, MOG epitopes. This functional segregation of pathogenic vs. non-pathogenic autoantibodies in terms of epitope specificity may be crucial to understand the relevance of MOG-specific responses in human disease. This commentary discusses these findings in the context of the structure and immunobiology of MOG, and their implications with respect to antibody-mediated demyelination in MS.

    Original languageEnglish
    Pages (from-to)2065-2071
    Number of pages6
    JournalEuropean Journal of Immunology
    Volume34
    Issue number8
    DOIs
    Publication statusPublished - 2004

    Keywords

    • B cells
    • demyelination
    • multiple sclerosis
    • experimental autoimmune encephalomyelitis
    • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
    • EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
    • MULTIPLE-SCLEROSIS PATHOLOGY
    • ANTIGEN-SPECIFIC ANTIBODY
    • B-CELL RESPONSES
    • MOG-INDUCED EAE
    • MYELIN/OLIGODENDROCYTE GLYCOPROTEIN
    • BASIC-PROTEIN
    • T-CELL
    • MONOCLONAL-ANTIBODY

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