Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence: The Generation Scotland Study

Riccardo E. Marioni; G. David Batty; Caroline Hayward; Shona M. Kerr; Archie Campbell; Lynne J. Hocking; Generation Scotland; David J. Porteous; Peter M. Visscher; Ian J. Deary

doi:10.1007/s10519-014-9644-z

Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence: The Generation Scotland Study

Riccardo E. Marioni^*, G. David Batty, Caroline Hayward, Shona M. Kerr, Archie Campbell, Lynne J. Hocking, Generation Scotland, David J. Porteous, Peter M. Visscher, Ian J. Deary

^*Corresponding author for this work

Medical Sciences

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

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Abstract

Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.

Original language	English
Pages (from-to)	91-96
Number of pages	6
Journal	Behavior Genetics
Volume	44
Issue number	2
Early online date	20 Feb 2014
DOIs	https://doi.org/10.1007/s10519-014-9644-z
Publication status	Published - Mar 2014

Keywords

height
intelligence
molecular genetics
genetic correlation
Generation Scotland
Scottish family health
heritability
metaanalysis
association
pleiotrpy
childhood
disease
samples
cohort

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Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence : The Generation Scotland Study. / Marioni, Riccardo E.; Batty, G. David; Hayward, Caroline; Kerr, Shona M.; Campbell, Archie; Hocking, Lynne J.; Scotland, Generation; Porteous, David J.; Visscher, Peter M.; Deary, Ian J.

In: Behavior Genetics, Vol. 44, No. 2, 03.2014, p. 91-96.

Research output: Contribution to journal › Article › peer-review

Marioni, Riccardo E. ; Batty, G. David ; Hayward, Caroline ; Kerr, Shona M. ; Campbell, Archie ; Hocking, Lynne J. ; Scotland, Generation ; Porteous, David J. ; Visscher, Peter M. ; Deary, Ian J. / Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence : The Generation Scotland Study. In: Behavior Genetics. 2014 ; Vol. 44, No. 2. pp. 91-96.

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