Abstract
Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.
| Original language | English |
|---|---|
| Pages (from-to) | 91-96 |
| Number of pages | 6 |
| Journal | Behavior Genetics |
| Volume | 44 |
| Issue number | 2 |
| Early online date | 20 Feb 2014 |
| DOIs | |
| Publication status | Published - Mar 2014 |
Keywords
- height
- intelligence
- molecular genetics
- genetic correlation
- Generation Scotland
- Scottish family health
- heritability
- metaanalysis
- association
- pleiotrpy
- childhood
- disease
- samples
- cohort
Cite this
Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence : The Generation Scotland Study. / Marioni, Riccardo E.; Batty, G. David; Hayward, Caroline; Kerr, Shona M.; Campbell, Archie; Hocking, Lynne J.; Scotland, Generation; Porteous, David J.; Visscher, Peter M.; Deary, Ian J.
In: Behavior Genetics, Vol. 44, No. 2, 03.2014, p. 91-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence
T2 - The Generation Scotland Study
AU - Marioni, Riccardo E.
AU - Batty, G. David
AU - Hayward, Caroline
AU - Kerr, Shona M.
AU - Campbell, Archie
AU - Hocking, Lynne J.
AU - Scotland, Generation
AU - Porteous, David J.
AU - Visscher, Peter M.
AU - Deary, Ian J.
N1 - Creative Commons Attribution License
PY - 2014/3
Y1 - 2014/3
N2 - Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.
AB - Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.
KW - height
KW - intelligence
KW - molecular genetics
KW - genetic correlation
KW - Generation Scotland
KW - Scottish family health
KW - heritability
KW - metaanalysis
KW - association
KW - pleiotrpy
KW - childhood
KW - disease
KW - samples
KW - cohort
U2 - 10.1007/s10519-014-9644-z
DO - 10.1007/s10519-014-9644-z
M3 - Article
VL - 44
SP - 91
EP - 96
JO - Behavior Genetics
JF - Behavior Genetics
SN - 0001-8244
IS - 2
ER -