Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

Esophageal Adenocarcinoma Genetics Consortium

Research output: Contribution to journalLetter

114 Citations (Scopus)

Abstract

Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to esophageal adenocarcinoma (EAC), a tumor with a very poor prognosis. We report the first genome-wide association study on Barrett's esophagus, comprising 1,852 UK cases and 5,172 UK controls in the discovery stage and 5,986 cases and 12,825 controls in the replication stage. Variants at two loci were associated with disease risk: chromosome 6p21, rs9257809 (Pcombined = 4.09 × 10-9; odds ratio (OR) = 1.21, 95% confidence interval (CI) =1.13–1.28), within the major histocompatibility complex locus, and chromosome 16q24, rs9936833 (Pcombined = 2.74 × 10-10; OR = 1.14, 95% CI = 1.10–1.19), for which the closest protein-coding gene is FOXF1, which is implicated in esophageal development and structure. We found evidence that many common variants of small effect contribute to genetic susceptibility to Barrett's esophagus and that SNP alleles predisposing to obesity also increase risk for Barrett's esophagus.
Original languageEnglish
Pages (from-to)1131-1136
Number of pages6
JournalNature Genetics
Volume44
Issue number10
Early online date9 Sep 2012
DOIs
Publication statusPublished - Oct 2012

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Barrett Esophagus
Chromosomes
Odds Ratio
Confidence Intervals
Hiatal Hernia
Genome-Wide Association Study
Genetic Predisposition to Disease
Major Histocompatibility Complex
Single Nucleotide Polymorphism
Stomach
Adenocarcinoma
Obesity
Alleles
Acids
Neoplasms
Proteins

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Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. / Esophageal Adenocarcinoma Genetics Consortium.

In: Nature Genetics, Vol. 44, No. 10, 10.2012, p. 1131-1136.

Research output: Contribution to journalLetter

Esophageal Adenocarcinoma Genetics Consortium. / Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. In: Nature Genetics. 2012 ; Vol. 44, No. 10. pp. 1131-1136.
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