Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

Yongyong Shi, Zhiqiang Li, Qi Xu, Ti Wang, Tao Li, Jiawei Shen, Fengyu Zhang, Jianhua Chen, Guoquan Zhou, Weidong Ji, Baojie Li, Yifeng Xu, Dengtang Liu, Peng Wang, Ping Yang, Benxiu Liu, Wensheng Sun, Chunling Wan, Shengying Qin, Guang He & 21 others Stacy Steinberg, Sven Cichon, Thomas Werge, Engilbert Sigurdsson, Sarah Tosato, Aarno Palotie, Markus M. Nöthen, Marcella Rietschel, Roel A. Ophoff, David A. Collier, Dan Rujescu, David St Clair, Hreinn Stefansson, Kari Stefansson, Jue Ji, Qingzhong Wang, Wenjin Li, Linqing Zheng, Hairong Zhang, Guoyin Feng, Lin He

Research output: Contribution to journalArticle

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Abstract

Schizophrenia is a severe mental disorder affecting ∼1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10 -10) and 1q24.2 (rs10489202, P = 9.50 × 10 -9). Our findings provide new insights into the pathogenesis of schizophrenia.

Original languageEnglish
Pages (from-to)1224-1227
Number of pages4
JournalNature Genetics
Volume43
DOIs
Publication statusPublished - 1 Dec 2011

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Schizophrenia
Population
Genome-Wide Association Study
Mental Disorders
Single Nucleotide Polymorphism
Meta-Analysis
Genome

ASJC Scopus subject areas

  • Genetics

Cite this

Shi, Y., Li, Z., Xu, Q., Wang, T., Li, T., Shen, J., ... He, L. (2011). Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nature Genetics, 43, 1224-1227. https://doi.org/10.1038/ng.980

Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. / Shi, Yongyong; Li, Zhiqiang; Xu, Qi; Wang, Ti; Li, Tao; Shen, Jiawei; Zhang, Fengyu; Chen, Jianhua; Zhou, Guoquan; Ji, Weidong; Li, Baojie; Xu, Yifeng; Liu, Dengtang; Wang, Peng; Yang, Ping; Liu, Benxiu; Sun, Wensheng; Wan, Chunling; Qin, Shengying; He, Guang; Steinberg, Stacy; Cichon, Sven; Werge, Thomas; Sigurdsson, Engilbert; Tosato, Sarah; Palotie, Aarno; Nöthen, Markus M.; Rietschel, Marcella; Ophoff, Roel A.; Collier, David A.; Rujescu, Dan; St Clair, David; Stefansson, Hreinn; Stefansson, Kari; Ji, Jue; Wang, Qingzhong; Li, Wenjin; Zheng, Linqing; Zhang, Hairong; Feng, Guoyin; He, Lin.

In: Nature Genetics, Vol. 43, 01.12.2011, p. 1224-1227.

Research output: Contribution to journalArticle

Shi, Y, Li, Z, Xu, Q, Wang, T, Li, T, Shen, J, Zhang, F, Chen, J, Zhou, G, Ji, W, Li, B, Xu, Y, Liu, D, Wang, P, Yang, P, Liu, B, Sun, W, Wan, C, Qin, S, He, G, Steinberg, S, Cichon, S, Werge, T, Sigurdsson, E, Tosato, S, Palotie, A, Nöthen, MM, Rietschel, M, Ophoff, RA, Collier, DA, Rujescu, D, St Clair, D, Stefansson, H, Stefansson, K, Ji, J, Wang, Q, Li, W, Zheng, L, Zhang, H, Feng, G & He, L 2011, 'Common variants on 8p12 and 1q24.2 confer risk of schizophrenia' Nature Genetics, vol. 43, pp. 1224-1227. https://doi.org/10.1038/ng.980
Shi Y, Li Z, Xu Q, Wang T, Li T, Shen J et al. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nature Genetics. 2011 Dec 1;43:1224-1227. https://doi.org/10.1038/ng.980
Shi, Yongyong ; Li, Zhiqiang ; Xu, Qi ; Wang, Ti ; Li, Tao ; Shen, Jiawei ; Zhang, Fengyu ; Chen, Jianhua ; Zhou, Guoquan ; Ji, Weidong ; Li, Baojie ; Xu, Yifeng ; Liu, Dengtang ; Wang, Peng ; Yang, Ping ; Liu, Benxiu ; Sun, Wensheng ; Wan, Chunling ; Qin, Shengying ; He, Guang ; Steinberg, Stacy ; Cichon, Sven ; Werge, Thomas ; Sigurdsson, Engilbert ; Tosato, Sarah ; Palotie, Aarno ; Nöthen, Markus M. ; Rietschel, Marcella ; Ophoff, Roel A. ; Collier, David A. ; Rujescu, Dan ; St Clair, David ; Stefansson, Hreinn ; Stefansson, Kari ; Ji, Jue ; Wang, Qingzhong ; Li, Wenjin ; Zheng, Linqing ; Zhang, Hairong ; Feng, Guoyin ; He, Lin. / Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. In: Nature Genetics. 2011 ; Vol. 43. pp. 1224-1227.
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abstract = "Schizophrenia is a severe mental disorder affecting ∼1{\%} of the world population, with heritability of up to 80{\%}. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10 -10) and 1q24.2 (rs10489202, P = 9.50 × 10 -9). Our findings provide new insights into the pathogenesis of schizophrenia.",
author = "Yongyong Shi and Zhiqiang Li and Qi Xu and Ti Wang and Tao Li and Jiawei Shen and Fengyu Zhang and Jianhua Chen and Guoquan Zhou and Weidong Ji and Baojie Li and Yifeng Xu and Dengtang Liu and Peng Wang and Ping Yang and Benxiu Liu and Wensheng Sun and Chunling Wan and Shengying Qin and Guang He and Stacy Steinberg and Sven Cichon and Thomas Werge and Engilbert Sigurdsson and Sarah Tosato and Aarno Palotie and N{\"o}then, {Markus M.} and Marcella Rietschel and Ophoff, {Roel A.} and Collier, {David A.} and Dan Rujescu and {St Clair}, David and Hreinn Stefansson and Kari Stefansson and Jue Ji and Qingzhong Wang and Wenjin Li and Linqing Zheng and Hairong Zhang and Guoyin Feng and Lin He",
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AU - Li, Zhiqiang

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AU - Shen, Jiawei

AU - Zhang, Fengyu

AU - Chen, Jianhua

AU - Zhou, Guoquan

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