Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

The COIN Collaborative Group

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173 Citations (Scopus)

Abstract

We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10 -10), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10 -10) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10 -10) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC.

Original languageEnglish
Pages (from-to)770-776
Number of pages7
JournalNature Genetics
Volume44
Issue number7
DOIs
Publication statusPublished - Jul 2012

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