Community-acquired pneumonia mortality: a potential link to antibiotic prescribing trends in general practice

David Brendan Price; D. Honeybourne; P. Little; R. T. Mayon-White; R. C. Read; Michael David Thomas; M. C. Wale; P. FitzGerald; A. R. Weston; Christopher Charles Winchester

doi:10.1016/j.rmed.2003.08.011

Community-acquired pneumonia mortality: a potential link to antibiotic prescribing trends in general practice

David Brendan Price, D. Honeybourne, P. Little, R. T. Mayon-White, R. C. Read, Michael David Thomas, M. C. Wale, P. FitzGerald, A. R. Weston, Christopher Charles Winchester

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Background: Community prescribing of antibiotics has decreased substantially in the UK in recent years. We examine the association between pneumonia mortality and recent changes in community-based antibiotic prescribing for lower respiratory tract infections (LRTI).

Methods: Retrospective analysis of aggregated data for pneumonia mortality, influenza incidence, and antibiotic prescribing for LRTI in England and Wales during 12-week winter periods between 1993/94 and 1999/2000.

Results: Winter antibiotic prescribing for LRTI showed a 30.0% decline since 1995/96. Over the same period, there was a 50.6% increase in winter excess pneumonia mortality adjusted for influenza incidence. Negative binomial regression analysis showed that the incidence of influenza alone had a significant association with winter pneumonia mortality (P<0.001). The analysis also showed the reduction in antibiotic prescribing had a small but significant association with mortality (P<0.001), when simultaneously modelling for influenza incidence.

Original language	English
Pages (from-to)	17-24
Number of pages	8
Journal	Respiratory Medicine
Volume	98
Issue number	1
DOIs	https://doi.org/10.1016/j.rmed.2003.08.011
Publication status	Published - 1 Jan 2004

Keywords

antibiotic prescribing
lower respiratory tract infection
community-acquired pneumonia mortality
retrospective analysis
England and Wales
influenza epidemics
primary-care
escherichia-coli
resistance
children
impact
rates

Access to Document

10.1016/j.rmed.2003.08.011

Cite this

@article{5ee29fb38f624d0ba579719b2315857f,

title = "Community-acquired pneumonia mortality: a potential link to antibiotic prescribing trends in general practice",

abstract = "Background: Community prescribing of antibiotics has decreased substantially in the UK in recent years. We examine the association between pneumonia mortality and recent changes in community-based antibiotic prescribing for lower respiratory tract infections (LRTI).Methods: Retrospective analysis of aggregated data for pneumonia mortality, influenza incidence, and antibiotic prescribing for LRTI in England and Wales during 12-week winter periods between 1993/94 and 1999/2000.Results: Winter antibiotic prescribing for LRTI showed a 30.0% decline since 1995/96. Over the same period, there was a 50.6% increase in winter excess pneumonia mortality adjusted for influenza incidence. Negative binomial regression analysis showed that the incidence of influenza alone had a significant association with winter pneumonia mortality (P<0.001). The analysis also showed the reduction in antibiotic prescribing had a small but significant association with mortality (P<0.001), when simultaneously modelling for influenza incidence.",

keywords = "antibiotic prescribing, lower respiratory tract infection, community-acquired pneumonia mortality, retrospective analysis, England and Wales, influenza epidemics, primary-care, escherichia-coli, resistance, children, impact, rates",

author = "Price, {David Brendan} and D. Honeybourne and P. Little and Mayon-White, {R. T.} and Read, {R. C.} and Thomas, {Michael David} and Wale, {M. C.} and P. FitzGerald and Weston, {A. R.} and Winchester, {Christopher Charles}",

year = "2004",

month = jan,

day = "1",

doi = "10.1016/j.rmed.2003.08.011",

language = "English",

volume = "98",

pages = "17--24",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Community-acquired pneumonia mortality

T2 - a potential link to antibiotic prescribing trends in general practice

AU - Price, David Brendan

AU - Honeybourne, D.

AU - Little, P.

AU - Mayon-White, R. T.

AU - Read, R. C.

AU - Thomas, Michael David

AU - Wale, M. C.

AU - FitzGerald, P.

AU - Weston, A. R.

AU - Winchester, Christopher Charles

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Background: Community prescribing of antibiotics has decreased substantially in the UK in recent years. We examine the association between pneumonia mortality and recent changes in community-based antibiotic prescribing for lower respiratory tract infections (LRTI).Methods: Retrospective analysis of aggregated data for pneumonia mortality, influenza incidence, and antibiotic prescribing for LRTI in England and Wales during 12-week winter periods between 1993/94 and 1999/2000.Results: Winter antibiotic prescribing for LRTI showed a 30.0% decline since 1995/96. Over the same period, there was a 50.6% increase in winter excess pneumonia mortality adjusted for influenza incidence. Negative binomial regression analysis showed that the incidence of influenza alone had a significant association with winter pneumonia mortality (P<0.001). The analysis also showed the reduction in antibiotic prescribing had a small but significant association with mortality (P<0.001), when simultaneously modelling for influenza incidence.

AB - Background: Community prescribing of antibiotics has decreased substantially in the UK in recent years. We examine the association between pneumonia mortality and recent changes in community-based antibiotic prescribing for lower respiratory tract infections (LRTI).Methods: Retrospective analysis of aggregated data for pneumonia mortality, influenza incidence, and antibiotic prescribing for LRTI in England and Wales during 12-week winter periods between 1993/94 and 1999/2000.Results: Winter antibiotic prescribing for LRTI showed a 30.0% decline since 1995/96. Over the same period, there was a 50.6% increase in winter excess pneumonia mortality adjusted for influenza incidence. Negative binomial regression analysis showed that the incidence of influenza alone had a significant association with winter pneumonia mortality (P<0.001). The analysis also showed the reduction in antibiotic prescribing had a small but significant association with mortality (P<0.001), when simultaneously modelling for influenza incidence.

KW - antibiotic prescribing

KW - lower respiratory tract infection

KW - community-acquired pneumonia mortality

KW - retrospective analysis

KW - England and Wales

KW - influenza epidemics

KW - primary-care

KW - escherichia-coli

KW - resistance

KW - children

KW - impact

KW - rates

U2 - 10.1016/j.rmed.2003.08.011

DO - 10.1016/j.rmed.2003.08.011

M3 - Article

VL - 98

SP - 17

EP - 24

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

IS - 1

ER -

Community-acquired pneumonia mortality: a potential link to antibiotic prescribing trends in general practice

Abstract

Keywords

Access to Document

Fingerprint

Cite this