@article{b2f65d9f624143ae9a896db28b2eeb39,
title = "Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi",
abstract = "Mitogen-activated protein kinase (MAPK) cascades and the calcium-calcineurin pathway control fundamental aspects of fungal growth, development and reproduction. Core elements of these signalling pathways are required for virulence in a wide array of fungal pathogens of plants and mammals. In this review, we have used the available genome databases to explore the structural conservation of three MAPK cascades and the calcium-calcineurin pathway in ten different fungal species, including model organisms, plant pathogens and human pathogens. While most known pathway components from the model yeast Saccharomyces cerevisiae appear to be widely conserved among taxonomically and biologically diverse fungi, some of them were found to be restricted to the Saccharomycotina. The presence of multiple paralogues in certain species such as the zygomycete Rhizopus oryzae and the incorporation of new functional domains that are lacking in S. cerevisiae signalling proteins, most likely reflect functional diversification or adaptation as filamentous fungi have evolved to occupy distinct ecological niches.",
keywords = "calcineurin, calcium, fungal proteins, fungi, genomics, humans, MAP kinase signaling system, mycoses, plant diseases, plants, protein kinases, signal transduction, MAPK signalling, stress, virulence",
author = "Nicolas Rispail and Soanes, {Darren M} and Cemile Ant and Robert Czajkowski and Anke Gr{\"u}nler and Romain Huguet and Elena Perez-Nadales and Anna Poli and Elodie Sartorel and Vito Valiante and Meng Yang and Roland Beffa and Brakhage, {Axel A} and Gow, {Neil A R} and Regine Kahmann and Marc-Henri Lebrun and Helena Lenasi and Jos{\'e} Perez-Martin and Talbot, {Nicholas J} and J{\"u}rgen Wendland and {Di Pietro}, Antonio",
note = "A paid open access option is available for this journal. Voluntary deposit by author of pre-print allowed on Institutions open scholarly website and pre-print servers Voluntary deposit by author of authors post-print allowed on institutions open scholarly website including Institutional Repository Deposit due to Funding Body, Institutional and Governmental mandate only allowed where separate agreement between repository and publisher exists Set statement to accompany deposit Published source must be acknowledged Must link to journal home page or articles' DOI Publisher's version/PDF cannot be used Articles in some journals can be made Open Access on payment of additional charge NIH Authors articles will be submitted to PubMed Central after 12 months Authors who are required to deposit in subject-based repositories may also use Sponsorship Option",
year = "2009",
month = apr,
doi = "10.1016/j.fgb.2009.01.002",
language = "English",
volume = "46",
pages = "287--298",
journal = "Fungal Genetics and Biology",
issn = "1087-1845",
publisher = "Academic Press Inc.",
number = "4",
}