Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi

Nicolas Rispail; Darren M Soanes; Cemile Ant; Robert Czajkowski; Anke Grünler; Romain Huguet; Elena Perez-Nadales; Anna Poli; Elodie Sartorel; Vito Valiante; Meng Yang; Roland Beffa; Axel A Brakhage; Neil A R Gow; Regine Kahmann; Marc-Henri Lebrun; Helena Lenasi; José Perez-Martin; Nicholas J Talbot; Jürgen Wendland; Antonio Di Pietro

doi:10.1016/j.fgb.2009.01.002

Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi

Nicolas Rispail, Darren M Soanes, Cemile Ant, Robert Czajkowski, Anke Grünler, Romain Huguet, Elena Perez-Nadales, Anna Poli, Elodie Sartorel, Vito Valiante, Meng Yang, Roland Beffa, Axel A Brakhage, Neil A R Gow, Regine Kahmann, Marc-Henri Lebrun, Helena Lenasi, José Perez-Martin, Nicholas J Talbot, Jürgen WendlandAntonio Di Pietro

Medical Sciences

Research output: Contribution to journal › Article › peer-review

253 Citations (Scopus)

Abstract

Mitogen-activated protein kinase (MAPK) cascades and the calcium-calcineurin pathway control fundamental aspects of fungal growth, development and reproduction. Core elements of these signalling pathways are required for virulence in a wide array of fungal pathogens of plants and mammals. In this review, we have used the available genome databases to explore the structural conservation of three MAPK cascades and the calcium-calcineurin pathway in ten different fungal species, including model organisms, plant pathogens and human pathogens. While most known pathway components from the model yeast Saccharomyces cerevisiae appear to be widely conserved among taxonomically and biologically diverse fungi, some of them were found to be restricted to the Saccharomycotina. The presence of multiple paralogues in certain species such as the zygomycete Rhizopus oryzae and the incorporation of new functional domains that are lacking in S. cerevisiae signalling proteins, most likely reflect functional diversification or adaptation as filamentous fungi have evolved to occupy distinct ecological niches.

Original language	English
Pages (from-to)	287-298
Number of pages	12
Journal	Fungal Genetics and Biology
Volume	46
Issue number	4
Early online date	28 Jan 2009
DOIs	https://doi.org/10.1016/j.fgb.2009.01.002
Publication status	Published - Apr 2009

Bibliographical note

A paid open access option is available for this journal.
Voluntary deposit by author of pre-print allowed on Institutions open scholarly website and pre-print servers
Voluntary deposit by author of authors post-print allowed on institutions open scholarly website including Institutional Repository
Deposit due to Funding Body, Institutional and Governmental mandate only allowed where separate agreement between repository and publisher exists
Set statement to accompany deposit
Published source must be acknowledged
Must link to journal home page or articles' DOI
Publisher's version/PDF cannot be used
Articles in some journals can be made Open Access on payment of additional charge
NIH Authors articles will be submitted to PubMed Central after 12 months
Authors who are required to deposit in subject-based repositories may also use Sponsorship Option

Keywords

calcineurin
calcium
fungal proteins
fungi
genomics
humans
MAP kinase signaling system
mycoses
plant diseases
plants
protein kinases
signal transduction
MAPK signalling
stress
virulence

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10.1016/j.fgb.2009.01.002

Cite this

Rispail, N., Soanes, D. M., Ant, C., Czajkowski, R., Grünler, A., Huguet, R., Perez-Nadales, E., Poli, A., Sartorel, E., Valiante, V., Yang, M., Beffa, R., Brakhage, A. A., Gow, N. A. R., Kahmann, R., Lebrun, M.-H., Lenasi, H., Perez-Martin, J., Talbot, N. J., ... Di Pietro, A. (2009). Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi. Fungal Genetics and Biology, 46(4), 287-298. https://doi.org/10.1016/j.fgb.2009.01.002

Rispail, N, Soanes, DM, Ant, C, Czajkowski, R, Grünler, A, Huguet, R, Perez-Nadales, E, Poli, A, Sartorel, E, Valiante, V, Yang, M, Beffa, R, Brakhage, AA, Gow, NAR, Kahmann, R, Lebrun, M-H, Lenasi, H, Perez-Martin, J, Talbot, NJ, Wendland, J & Di Pietro, A 2009, 'Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi', Fungal Genetics and Biology, vol. 46, no. 4, pp. 287-298. https://doi.org/10.1016/j.fgb.2009.01.002

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abstract = "Mitogen-activated protein kinase (MAPK) cascades and the calcium-calcineurin pathway control fundamental aspects of fungal growth, development and reproduction. Core elements of these signalling pathways are required for virulence in a wide array of fungal pathogens of plants and mammals. In this review, we have used the available genome databases to explore the structural conservation of three MAPK cascades and the calcium-calcineurin pathway in ten different fungal species, including model organisms, plant pathogens and human pathogens. While most known pathway components from the model yeast Saccharomyces cerevisiae appear to be widely conserved among taxonomically and biologically diverse fungi, some of them were found to be restricted to the Saccharomycotina. The presence of multiple paralogues in certain species such as the zygomycete Rhizopus oryzae and the incorporation of new functional domains that are lacking in S. cerevisiae signalling proteins, most likely reflect functional diversification or adaptation as filamentous fungi have evolved to occupy distinct ecological niches.",

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note = "A paid open access option is available for this journal. Voluntary deposit by author of pre-print allowed on Institutions open scholarly website and pre-print servers Voluntary deposit by author of authors post-print allowed on institutions open scholarly website including Institutional Repository Deposit due to Funding Body, Institutional and Governmental mandate only allowed where separate agreement between repository and publisher exists Set statement to accompany deposit Published source must be acknowledged Must link to journal home page or articles' DOI Publisher's version/PDF cannot be used Articles in some journals can be made Open Access on payment of additional charge NIH Authors articles will be submitted to PubMed Central after 12 months Authors who are required to deposit in subject-based repositories may also use Sponsorship Option",

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AU - Grünler, Anke

AU - Huguet, Romain

AU - Perez-Nadales, Elena

AU - Poli, Anna

AU - Sartorel, Elodie

AU - Valiante, Vito

AU - Yang, Meng

AU - Beffa, Roland

AU - Brakhage, Axel A

AU - Gow, Neil A R

AU - Kahmann, Regine

AU - Lebrun, Marc-Henri

AU - Lenasi, Helena

AU - Perez-Martin, José

AU - Talbot, Nicholas J

AU - Wendland, Jürgen

AU - Di Pietro, Antonio

N1 - A paid open access option is available for this journal. Voluntary deposit by author of pre-print allowed on Institutions open scholarly website and pre-print servers Voluntary deposit by author of authors post-print allowed on institutions open scholarly website including Institutional Repository Deposit due to Funding Body, Institutional and Governmental mandate only allowed where separate agreement between repository and publisher exists Set statement to accompany deposit Published source must be acknowledged Must link to journal home page or articles' DOI Publisher's version/PDF cannot be used Articles in some journals can be made Open Access on payment of additional charge NIH Authors articles will be submitted to PubMed Central after 12 months Authors who are required to deposit in subject-based repositories may also use Sponsorship Option

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N2 - Mitogen-activated protein kinase (MAPK) cascades and the calcium-calcineurin pathway control fundamental aspects of fungal growth, development and reproduction. Core elements of these signalling pathways are required for virulence in a wide array of fungal pathogens of plants and mammals. In this review, we have used the available genome databases to explore the structural conservation of three MAPK cascades and the calcium-calcineurin pathway in ten different fungal species, including model organisms, plant pathogens and human pathogens. While most known pathway components from the model yeast Saccharomyces cerevisiae appear to be widely conserved among taxonomically and biologically diverse fungi, some of them were found to be restricted to the Saccharomycotina. The presence of multiple paralogues in certain species such as the zygomycete Rhizopus oryzae and the incorporation of new functional domains that are lacking in S. cerevisiae signalling proteins, most likely reflect functional diversification or adaptation as filamentous fungi have evolved to occupy distinct ecological niches.

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KW - calcium

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KW - genomics

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KW - mycoses

KW - plant diseases

KW - plants

KW - protein kinases

KW - signal transduction

KW - MAPK signalling

KW - stress

KW - virulence

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DO - 10.1016/j.fgb.2009.01.002

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SN - 1087-1845

VL - 46

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EP - 298

JO - Fungal Genetics and Biology

JF - Fungal Genetics and Biology

IS - 4

ER -

Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi

Abstract

Bibliographical note

Keywords

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