Comparison of Perinatal Outcomes for Women With and Without Epilepsy: A Systematic Review and Meta-analysis

Paolo Pierino Mazzone, Kirsty Mhairi Hogg, Christopher J. Weir, Jacqueline Stephen, Sohinee Bhattacharya, Richard F. M. Chin

Research output: Contribution to journalArticlepeer-review

1 Downloads (Pure)


Pregnant women who have epilepsy need adequate engagement, information, and pregnancy planning and management to improve pregnancy outcomes.To investigate perinatal outcomes in women with epilepsy compared with women without epilepsy.Ovid MEDLINE, Embase, CINAHL, and PsycINFO were searched with no language or date restrictions (database inception through December 6, 2022). Searches also included OpenGrey and Google Scholar and manual searching in journals and reference lists of included studies.All observational studies comparing women with and without epilepsy were included.The PRISMA checklist was used for abstracting data and the Newcastle-Ottawa Scale for risk-of-bias assessment. Data extraction and risk-of-bias assessment were done independently by 2 authors with mediation conducted independently by a third author. Pooled unadjusted odds ratios (OR) or mean differences were reported with 95\effects (I2 heterogeneity statistic \gt;50\ or fixed-effects (I2 \lt; 50\ meta-analyses.Maternal, fetal, and neonatal complications.Of 8313 articles identified, 76 were included in the meta-analyses. Women with epilepsy had increased odds of miscarriage (12 articles, 25 478 pregnancies; OR, 1.62; 95\ 1.15-2.29), stillbirth (20 articles, 28 134 229 pregnancies; OR, 1.37; 95\ 1.29-1.47), preterm birth (37 articles, 29 268 866 pregnancies; OR, 1.41; 95\ 1.32-1.51) and maternal death (4 articles, 23 288 083 pregnancies; OR, 5.00; 95\ 1.38-18.04). Neonates born to women with epilepsy had increased odds of congenital conditions (29 articles, 24 238 334 pregnancies; OR, 1.88; 95\ 1.66-2.12), neonatal intensive care unit admission (8 articles, 1 204 428 pregnancies; OR, 1.99; 95\ 1.58-2.51), and neonatal or infant death (13 articles, 1 426 692 pregnancies; OR, 1.87; 95\ 1.56-2.24). The increased odds of poor outcomes was increased with greater use of antiseizure medication.This systematic review and meta-analysis found that women with epilepsy have worse perinatal outcomes compared with women without epilepsy. Women with epilepsy should receive pregnancy counseling from an epilepsy specialist who can also optimize their antiseizure medication regimen before and during pregnancy.
Original languageEnglish
Number of pages10
JournalJAMA Neurology
Early online date13 Mar 2023
Publication statusE-pub ahead of print - 13 Mar 2023


Dive into the research topics of 'Comparison of Perinatal Outcomes for Women With and Without Epilepsy: A Systematic Review and Meta-analysis'. Together they form a unique fingerprint.

Cite this