Conflicting interests in the pathogen-host tug of war: fungal micronutrient scavenging versus mammalian nutritional immunity

Joanna Potrykus, Elizabeth R Ballou, Delma S Childers, Alistair J P Brown

Research output: Contribution to journalLiterature review

25 Citations (Scopus)
5 Downloads (Pure)

Abstract

Strife concerning the accessibility of essential trace elements, such as transition metals, represents an important aspect of the dynamic interaction between a pathogenic fungus and its mammalian host. The host defends itself against infection by sequestering these essential micronutrients away from the invading pathogen via a phenomenon termed “nutritional immunity” . In turn, the fungus employs an array of tactics (scavenging and storage) to hoard micronutrients and support growth when these resources are scarce. In addition, micronutrient limitation triggers the expression of virulence determinants that can aggravate disease
Original languageEnglish
Article numbere1003910
Number of pages4
JournalPLoS Pathogens
Volume10
Issue number3
DOIs
Publication statusPublished - 13 Mar 2014

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