Considerable differences exist between prevalent and incident myocardial infarction cohorts derived from the same population

Brian S Buckley, Colin R Simpson, David J McLernon, Philip C Hannaford, Andrew W Murphy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective
Both prevalent and incidentcohorts have been used in epidemiological and prognostic studies of ischemic heart disease (IHD). This study considers the differences between the cohort types.

Study Design and Setting
Using linked primary care, secondary care, and death certification data, prevalent and incidentcohorts of people with a first acute myocardialinfarction (AMI) were formed from the samepopulation. They were analyzed independently in terms of baseline characteristics and survival to revascularization, another AMI, or death.

Results
55.7% of the prevalentcohort members were males, with a mean age of 71.0 years (standard deviation [SD]: 12.0). 59.0% of the incidentcohort members were males, with a mean age of 64.7 years (SD: 13.3). Over 5 years, a greater proportion of prevalent cases died from any cause (31.4% [95% confidence interval(CI): 28.6–34.3]) and IHD (18.5% [95% CI: 16.2–21.0]) than incident cases (18.0% [95% CI: 15.0–21.4] and 12.2% [95% CI: 9.7–15.2], respectively). Mean time to death was shorter in prevalent cases. There was a small difference in the numbers of subsequent AMIs between cohorts. In the incidentcohort, mean time to AMI was shorter. Fewer prevalent cases underwent coronary artery bypass grafting or percutaneous transluminal coronary angioplasty.

Conclusion
Considerabledifferences existed between the two cohorts in terms of baseline characteristics and prognosis. Incidentcohortsderived from whole populations should be sought for estimation of survival.
Original languageEnglish
Pages (from-to)1351-1357
Number of pages7
JournalJournal of Clinical Epidemiology
Volume63
Issue number12
Early online date14 May 2010
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Myocardial Infarction
Confidence Intervals
Population
Myocardial Ischemia
Secondary Care
Coronary Balloon Angioplasty
Certification
Coronary Artery Bypass
Epidemiologic Studies
Primary Health Care

Keywords

  • cohort studies
  • prognosis
  • survival
  • prevalence
  • incidence
  • myocardial infarction

Cite this

Considerable differences exist between prevalent and incident myocardial infarction cohorts derived from the same population. / Buckley, Brian S; Simpson, Colin R; McLernon, David J; Hannaford, Philip C; Murphy, Andrew W.

In: Journal of Clinical Epidemiology, Vol. 63, No. 12, 12.2010, p. 1351-1357.

Research output: Contribution to journalArticle

@article{19cb2896df5640c782a1c612fd64f58e,
title = "Considerable differences exist between prevalent and incident myocardial infarction cohorts derived from the same population",
abstract = "Objective Both prevalent and incidentcohorts have been used in epidemiological and prognostic studies of ischemic heart disease (IHD). This study considers the differences between the cohort types. Study Design and Setting Using linked primary care, secondary care, and death certification data, prevalent and incidentcohorts of people with a first acute myocardialinfarction (AMI) were formed from the samepopulation. They were analyzed independently in terms of baseline characteristics and survival to revascularization, another AMI, or death. Results 55.7{\%} of the prevalentcohort members were males, with a mean age of 71.0 years (standard deviation [SD]: 12.0). 59.0{\%} of the incidentcohort members were males, with a mean age of 64.7 years (SD: 13.3). Over 5 years, a greater proportion of prevalent cases died from any cause (31.4{\%} [95{\%} confidence interval(CI): 28.6–34.3]) and IHD (18.5{\%} [95{\%} CI: 16.2–21.0]) than incident cases (18.0{\%} [95{\%} CI: 15.0–21.4] and 12.2{\%} [95{\%} CI: 9.7–15.2], respectively). Mean time to death was shorter in prevalent cases. There was a small difference in the numbers of subsequent AMIs between cohorts. In the incidentcohort, mean time to AMI was shorter. Fewer prevalent cases underwent coronary artery bypass grafting or percutaneous transluminal coronary angioplasty. Conclusion Considerabledifferences existed between the two cohorts in terms of baseline characteristics and prognosis. Incidentcohortsderived from whole populations should be sought for estimation of survival.",
keywords = "cohort studies, prognosis, survival, prevalence, incidence, myocardial infarction",
author = "Buckley, {Brian S} and Simpson, {Colin R} and McLernon, {David J} and Hannaford, {Philip C} and Murphy, {Andrew W}",
year = "2010",
month = "12",
doi = "10.1016/j.jclinepi.2010.01.017",
language = "English",
volume = "63",
pages = "1351--1357",
journal = "Journal of Clinical Epidemiology",
issn = "0895-4356",
publisher = "Elsevier USA",
number = "12",

}

TY - JOUR

T1 - Considerable differences exist between prevalent and incident myocardial infarction cohorts derived from the same population

AU - Buckley, Brian S

AU - Simpson, Colin R

AU - McLernon, David J

AU - Hannaford, Philip C

AU - Murphy, Andrew W

PY - 2010/12

Y1 - 2010/12

N2 - Objective Both prevalent and incidentcohorts have been used in epidemiological and prognostic studies of ischemic heart disease (IHD). This study considers the differences between the cohort types. Study Design and Setting Using linked primary care, secondary care, and death certification data, prevalent and incidentcohorts of people with a first acute myocardialinfarction (AMI) were formed from the samepopulation. They were analyzed independently in terms of baseline characteristics and survival to revascularization, another AMI, or death. Results 55.7% of the prevalentcohort members were males, with a mean age of 71.0 years (standard deviation [SD]: 12.0). 59.0% of the incidentcohort members were males, with a mean age of 64.7 years (SD: 13.3). Over 5 years, a greater proportion of prevalent cases died from any cause (31.4% [95% confidence interval(CI): 28.6–34.3]) and IHD (18.5% [95% CI: 16.2–21.0]) than incident cases (18.0% [95% CI: 15.0–21.4] and 12.2% [95% CI: 9.7–15.2], respectively). Mean time to death was shorter in prevalent cases. There was a small difference in the numbers of subsequent AMIs between cohorts. In the incidentcohort, mean time to AMI was shorter. Fewer prevalent cases underwent coronary artery bypass grafting or percutaneous transluminal coronary angioplasty. Conclusion Considerabledifferences existed between the two cohorts in terms of baseline characteristics and prognosis. Incidentcohortsderived from whole populations should be sought for estimation of survival.

AB - Objective Both prevalent and incidentcohorts have been used in epidemiological and prognostic studies of ischemic heart disease (IHD). This study considers the differences between the cohort types. Study Design and Setting Using linked primary care, secondary care, and death certification data, prevalent and incidentcohorts of people with a first acute myocardialinfarction (AMI) were formed from the samepopulation. They were analyzed independently in terms of baseline characteristics and survival to revascularization, another AMI, or death. Results 55.7% of the prevalentcohort members were males, with a mean age of 71.0 years (standard deviation [SD]: 12.0). 59.0% of the incidentcohort members were males, with a mean age of 64.7 years (SD: 13.3). Over 5 years, a greater proportion of prevalent cases died from any cause (31.4% [95% confidence interval(CI): 28.6–34.3]) and IHD (18.5% [95% CI: 16.2–21.0]) than incident cases (18.0% [95% CI: 15.0–21.4] and 12.2% [95% CI: 9.7–15.2], respectively). Mean time to death was shorter in prevalent cases. There was a small difference in the numbers of subsequent AMIs between cohorts. In the incidentcohort, mean time to AMI was shorter. Fewer prevalent cases underwent coronary artery bypass grafting or percutaneous transluminal coronary angioplasty. Conclusion Considerabledifferences existed between the two cohorts in terms of baseline characteristics and prognosis. Incidentcohortsderived from whole populations should be sought for estimation of survival.

KW - cohort studies

KW - prognosis

KW - survival

KW - prevalence

KW - incidence

KW - myocardial infarction

U2 - 10.1016/j.jclinepi.2010.01.017

DO - 10.1016/j.jclinepi.2010.01.017

M3 - Article

VL - 63

SP - 1351

EP - 1357

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

SN - 0895-4356

IS - 12

ER -