Afwegingen bij de keuze tussen intra-uteriene inseminatie en in- vitrofertilisatie als behandeling van subfertiliteit

Translated title of the contribution: Considerations in the choice between intra-uterine insemination and in vitro fertilization as treatment for subfertility

B. W. Mol*, A. Goverde

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Both intrauterine insemination (IUI) and in vitro fertilization (IVF) may be considered in treating couples with subfertility. Although the indications for IUI generally point to a less serious form of subfertility than the indications for IVF, there still appears to be an important overlap between the indications for both treatments. This article discusses the pros and cons in the choice between IUI and IVF based on the available literature. We found three randomized studies and one nonrandomized study in which IVF was compared with IUI with stimulation. In all studies, the pregnancy rate per cycle after IVF was higher than after IUI: with IVF it varied between 18% and 38%, with IUI between 10% and 20%. The number of multiple birth pregnancies was so small that a reliable estimate could not be derived from these studies. If the consideration between IUI and IVF is reduced to a cost effectiveness issue (in terms of costs per fulfilled wish to have children), a first cycle of IUI is generally preferable to a first cycle of IVF (IVF is at least 2.5 times as expensive as IUI, is less burdensome and generates a lower risk of multiple births). The IUI success rate may even decline as far as 11% to keep both treatments equally cost-effective.

Translated title of the contributionConsiderations in the choice between intra-uterine insemination and in vitro fertilization as treatment for subfertility
Original languageDutch
Pages (from-to)100-103
Number of pages4
JournalTijdschrift voor Fertiliteitsonderzoek
Volume13
Issue number4
Publication statusPublished - 1 Dec 1999

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