Contact dermatitis from the old formula E45 cream

T L Batten; R A Wakeel; W.S. Douglas; C Evans; Marion White; R Moody; Anthony Ormerod

doi:10.1111/j.1600-0536.1994.tb00697.x

Contact dermatitis from the old formula E45 cream

T L Batten, R A Wakeel, W.S. Douglas, C Evans, Marion White, R Moody, Anthony Ormerod

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In the past 4 years, a high incidence (118/362) of positive patch test reactions to E45 cream were noted in 2 patch testing clinics. 18/54 of those patch tested to all the ingredients demonstrated allergies to ingredients. The most frequent was triethanolamine; lanolin allergy occurring in only 1 patient. The remaining reactions may be explained as irritant reactions resulting from triethanolamine stearate (TES) formation within the cream. The irritancy of triethanolamine stearate was demonstrated in patients and controls. Conductivity studies showed that TES arises from the combination of the ingredients triethanolamine and stearic acid. The formulation of E45 cream was being changed at the time of writing, with the removal of triethanolamine from the product.

Original language	English
Pages (from-to)	159-161
Number of pages	3
Journal	Contact Dermatitis
Volume	30
Issue number	3
DOIs	https://doi.org/10.1111/j.1600-0536.1994.tb00697.x
Publication status	Published - 1 Mar 1994

Keywords

Chemistry, Pharmaceutical
Dermatitis, Allergic Contact
Dermatitis, Irritant
Electric Conductivity
Emollients
Ethanolamines
Humans
Methanol
Stearic Acids
E45 cream
Allergic contact dermatitis
Triethanolamine
Glyceryl monostearate
Stearic Acid
Parabens
Lanolin
False-positive patch test reactions
Triethanolamine stearate
Compund irritancy
Medicaments

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10.1111/j.1600-0536.1994.tb00697.x

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title = "Contact dermatitis from the old formula E45 cream",

abstract = "In the past 4 years, a high incidence (118/362) of positive patch test reactions to E45 cream were noted in 2 patch testing clinics. 18/54 of those patch tested to all the ingredients demonstrated allergies to ingredients. The most frequent was triethanolamine; lanolin allergy occurring in only 1 patient. The remaining reactions may be explained as irritant reactions resulting from triethanolamine stearate (TES) formation within the cream. The irritancy of triethanolamine stearate was demonstrated in patients and controls. Conductivity studies showed that TES arises from the combination of the ingredients triethanolamine and stearic acid. The formulation of E45 cream was being changed at the time of writing, with the removal of triethanolamine from the product.",

keywords = "Chemistry, Pharmaceutical, Dermatitis, Allergic Contact, Dermatitis, Irritant, Electric Conductivity, Emollients, Ethanolamines, Humans, Methanol, Stearic Acids, E45 cream, Allergic contact dermatitis, Triethanolamine, Glyceryl monostearate, Stearic Acid, Parabens, Lanolin, False-positive patch test reactions, Triethanolamine stearate, Compund irritancy, Medicaments",

author = "Batten, {T L} and Wakeel, {R A} and W.S. Douglas and C Evans and Marion White and R Moody and Anthony Ormerod",

year = "1994",

month = mar,

day = "1",

doi = "10.1111/j.1600-0536.1994.tb00697.x",

language = "English",

volume = "30",

pages = "159--161",

journal = "Contact Dermatitis",

issn = "1600-0536",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Contact dermatitis from the old formula E45 cream

AU - Batten, T L

AU - Wakeel, R A

AU - Douglas, W.S.

AU - Evans, C

AU - White, Marion

AU - Moody, R

AU - Ormerod, Anthony

PY - 1994/3/1

Y1 - 1994/3/1

N2 - In the past 4 years, a high incidence (118/362) of positive patch test reactions to E45 cream were noted in 2 patch testing clinics. 18/54 of those patch tested to all the ingredients demonstrated allergies to ingredients. The most frequent was triethanolamine; lanolin allergy occurring in only 1 patient. The remaining reactions may be explained as irritant reactions resulting from triethanolamine stearate (TES) formation within the cream. The irritancy of triethanolamine stearate was demonstrated in patients and controls. Conductivity studies showed that TES arises from the combination of the ingredients triethanolamine and stearic acid. The formulation of E45 cream was being changed at the time of writing, with the removal of triethanolamine from the product.

AB - In the past 4 years, a high incidence (118/362) of positive patch test reactions to E45 cream were noted in 2 patch testing clinics. 18/54 of those patch tested to all the ingredients demonstrated allergies to ingredients. The most frequent was triethanolamine; lanolin allergy occurring in only 1 patient. The remaining reactions may be explained as irritant reactions resulting from triethanolamine stearate (TES) formation within the cream. The irritancy of triethanolamine stearate was demonstrated in patients and controls. Conductivity studies showed that TES arises from the combination of the ingredients triethanolamine and stearic acid. The formulation of E45 cream was being changed at the time of writing, with the removal of triethanolamine from the product.

KW - Chemistry, Pharmaceutical

KW - Dermatitis, Allergic Contact

KW - Dermatitis, Irritant

KW - Electric Conductivity

KW - Emollients

KW - Ethanolamines

KW - Humans

KW - Methanol

KW - Stearic Acids

KW - E45 cream

KW - Allergic contact dermatitis

KW - Triethanolamine

KW - Glyceryl monostearate

KW - Stearic Acid

KW - Parabens

KW - Lanolin

KW - False-positive patch test reactions

KW - Triethanolamine stearate

KW - Compund irritancy

KW - Medicaments

U2 - 10.1111/j.1600-0536.1994.tb00697.x

DO - 10.1111/j.1600-0536.1994.tb00697.x

M3 - Article

C2 - 8187515

SN - 1600-0536

VL - 30

SP - 159

EP - 161

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 3

ER -

Contact dermatitis from the old formula E45 cream

Abstract

Keywords

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