Contractions of the whole and longitudinally cut rat's portal vein

Vera Gal; Mirjana M Platiša; Zorica Nestorović; Milica Labudović Borović; Vesna Vuksanovic; Ljiljana Gojković Bukarica

doi:10.1016/j.compbiomed.2013.05.015

Contractions of the whole and longitudinally cut rat's portal vein

Vera Gal, Mirjana M Platiša, Zorica Nestorović, Milica Labudović Borović, Vesna Vuksanovic, Ljiljana Gojković Bukarica

Research output: Contribution to journal › Article

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Abstract

To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut rat´s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions.

Original language	English
Pages (from-to)	1114-1119
Number of pages	6
Journal	Computers in Biology and Medicine
Volume	43
Issue number	9
Early online date	2 Jun 2013
DOIs	https://doi.org/10.1016/j.compbiomed.2013.05.015
Publication status	Published - Sep 2013

Keywords

4-Aminopyridine
Animals
Endothelium, Vascular
Entropy
Muscle Contraction
Portal Vein
Potassium Channel Blockers
Rats
Rats, Inbred WKY
Vasoconstriction

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Gal, V., Platiša, M. M., Nestorović, Z., Labudović Borović, M., Vuksanovic, V., & Gojković Bukarica, L. (2013). Contractions of the whole and longitudinally cut rat's portal vein. Computers in Biology and Medicine, 43(9), 1114-1119. https://doi.org/10.1016/j.compbiomed.2013.05.015

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abstract = "To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut rat´s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions.",

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AU - Gal, Vera

AU - Platiša, Mirjana M

AU - Nestorović, Zorica

AU - Labudović Borović, Milica

AU - Vuksanovic, Vesna

AU - Gojković Bukarica, Ljiljana

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N2 - To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut rat´s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions.

AB - To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut rat´s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions.

KW - 4-Aminopyridine

KW - Animals

KW - Endothelium, Vascular

KW - Entropy

KW - Muscle Contraction

KW - Portal Vein

KW - Potassium Channel Blockers

KW - Rats

KW - Rats, Inbred WKY

KW - Vasoconstriction

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DO - 10.1016/j.compbiomed.2013.05.015

M3 - Article

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JO - Computers in Biology and Medicine

JF - Computers in Biology and Medicine

SN - 0010-4825

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