Abstract
To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut rat´s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 1114-1119 |
| Number of pages | 6 |
| Journal | Computers in Biology and Medicine |
| Volume | 43 |
| Issue number | 9 |
| Early online date | 2 Jun 2013 |
| DOIs | |
| Publication status | Published - Sep 2013 |
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Keywords
- 4-Aminopyridine
- Animals
- Endothelium, Vascular
- Entropy
- Muscle Contraction
- Portal Vein
- Potassium Channel Blockers
- Rats
- Rats, Inbred WKY
- Vasoconstriction
Cite this
Contractions of the whole and longitudinally cut rat's portal vein. / Gal, Vera; Platiša, Mirjana M; Nestorović, Zorica; Labudović Borović, Milica; Vuksanovic, Vesna; Gojković Bukarica, Ljiljana.
In: Computers in Biology and Medicine, Vol. 43, No. 9, 09.2013, p. 1114-1119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Contractions of the whole and longitudinally cut rat's portal vein
AU - Gal, Vera
AU - Platiša, Mirjana M
AU - Nestorović, Zorica
AU - Labudović Borović, Milica
AU - Vuksanovic, Vesna
AU - Gojković Bukarica, Ljiljana
N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.
PY - 2013/9
Y1 - 2013/9
N2 - To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut rat´s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions.
AB - To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut rat´s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions.
KW - 4-Aminopyridine
KW - Animals
KW - Endothelium, Vascular
KW - Entropy
KW - Muscle Contraction
KW - Portal Vein
KW - Potassium Channel Blockers
KW - Rats
KW - Rats, Inbred WKY
KW - Vasoconstriction
U2 - 10.1016/j.compbiomed.2013.05.015
DO - 10.1016/j.compbiomed.2013.05.015
M3 - Article
VL - 43
SP - 1114
EP - 1119
JO - Computers in Biology and Medicine
JF - Computers in Biology and Medicine
SN - 0010-4825
IS - 9
ER -