Contractions of the whole and longitudinally cut rat's portal vein

Vera Gal, Mirjana M Platiša, Zorica Nestorović, Milica Labudović Borović, Vesna Vuksanovic, Ljiljana Gojković Bukarica

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Abstract

To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut rat´s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions.

Original languageEnglish
Pages (from-to)1114-1119
Number of pages6
JournalComputers in Biology and Medicine
Volume43
Issue number9
Early online date2 Jun 2013
DOIs
Publication statusPublished - Sep 2013

Keywords

  • 4-Aminopyridine
  • Animals
  • Endothelium, Vascular
  • Entropy
  • Muscle Contraction
  • Portal Vein
  • Potassium Channel Blockers
  • Rats
  • Rats, Inbred WKY
  • Vasoconstriction

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  • Cite this

    Gal, V., Platiša, M. M., Nestorović, Z., Labudović Borović, M., Vuksanovic, V., & Gojković Bukarica, L. (2013). Contractions of the whole and longitudinally cut rat's portal vein. Computers in Biology and Medicine, 43(9), 1114-1119. https://doi.org/10.1016/j.compbiomed.2013.05.015