Abstract
To investigate the role of lateral interactions, we quantified spontaneous contractions of whole and longitudinally cut rat´s portal vein in vitro. The disruption of the wall had no effect on basic frequency determined from spectra and complexity index (CI) calculated by multiscale entropy analysis. Endothelium was disrupted and nonfunctional in all samples. Considering amplitude, frequency and CI we identified two modes of contractions. Neither mode of contractions nor the effect of aminopyridine (4-AP) depended on the integrity of the wall. We concluded that contractions in vitro originate in smooth muscle cells without involvement of the endothelium and lateral interactions.
Original language | English |
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Pages (from-to) | 1114-1119 |
Number of pages | 6 |
Journal | Computers in Biology and Medicine |
Volume | 43 |
Issue number | 9 |
Early online date | 2 Jun 2013 |
DOIs | |
Publication status | Published - Sep 2013 |
Keywords
- 4-Aminopyridine
- Animals
- Endothelium, Vascular
- Entropy
- Muscle Contraction
- Portal Vein
- Potassium Channel Blockers
- Rats
- Rats, Inbred WKY
- Vasoconstriction