Contrasting networks for recognition memory and recency memory revealed by immediate-early gene imaging in the rat

Cristian M Olarte-Sánchez, Lisa Kinnavane, Eman Amin, John P Aggleton

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The expression of the immediate-early gene c-fos was used to compare networks of activity associated with recency memory (temporal order memory) and recognition memory. In Experiment 1, rats were first familiarized with sets of objects and then given pairs of different, familiar objects to explore. For the recency test group, each object in a pair was separated by 110 min in the time between their previous presentations. For the recency control test, each object in a pair was separated by less than a 1 min between their prior presentations. Temporal discrimination of the objects correlated with c-fos activity in the recency test group in several sites, including area Te2, the perirhinal cortex, lateral entorhinal cortex, as well as the dentate gyrus, hippocampal fields CA3 and CA1. For both the test and control conditions, network models were derived using structural equation modeling. The recency test model emphasized serial connections from the perirhinal cortex to lateral entorhinal cortex and then to the CA1 subfield. The recency control condition involved more parallel pathways, but again highlighted CA1 within the hippocampus. Both models contrasted with those derived from tests of object recognition (Experiment 2), because stimulus novelty was associated with pathways from the perirhinal cortex to lateral entorhinal cortex that then involved both the dentate gyrus (and CA3) and CA1 in parallel. The present findings implicate CA1 for the processing of familiar stimuli, including recency discriminations, while the dentate gyrus and CA3 pathways are recruited when the perirhinal cortex signals novel stimuli.

Original languageEnglish
Pages (from-to)504-522
Number of pages19
JournalBehavioral Neuroscience
Volume128
Issue number4
Early online date16 Jun 2014
DOIs
Publication statusPublished - Aug 2014

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Immediate-Early Genes
Entorhinal Cortex
Dentate Gyrus
Hippocampus
Perirhinal Cortex
Recognition (Psychology)
Discrimination (Psychology)

Keywords

  • immediate-early genes
  • network models
  • rat
  • recency memory
  • recognition memory

Cite this

Contrasting networks for recognition memory and recency memory revealed by immediate-early gene imaging in the rat. / Olarte-Sánchez, Cristian M; Kinnavane, Lisa; Amin, Eman; Aggleton, John P.

In: Behavioral Neuroscience, Vol. 128, No. 4, 08.2014, p. 504-522.

Research output: Contribution to journalArticle

Olarte-Sánchez, Cristian M ; Kinnavane, Lisa ; Amin, Eman ; Aggleton, John P. / Contrasting networks for recognition memory and recency memory revealed by immediate-early gene imaging in the rat. In: Behavioral Neuroscience. 2014 ; Vol. 128, No. 4. pp. 504-522.
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